Faculty Opinions recommendation of Concise review: hurdles in a successful example of limbal stem cell-based regenerative medicine.

2017 ◽  
Author(s):  
Pamela Robey
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Concise Review ◽  
Limbal Stem Cell

scholarly journals Concise Review: Hurdles in a Successful Example of Limbal Stem Cell-based Regenerative Medicine

Stem Cells ◽  
2014 ◽  
Vol 32 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Graziella Pellegrini ◽  
Paolo Rama ◽  
Antonio Di Rocco ◽  
Athanasios Panaras ◽  
Michele De Luca
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Concise Review ◽  
Limbal Stem Cell

scholarly journals Goals and Challenges of Stem Cell-Based Therapy for Corneal Blindness Due to Limbal Deficiency

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1483
Author(s):  
Margarita Calonge ◽  
Teresa Nieto-Miguel ◽  
Ana de la Mata ◽  
Sara Galindo ◽  
José M. Herreras ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Stem Cell Niche ◽  
Basic Research ◽  
Cell Based Therapy ◽  
Novel Approach ◽  
Corneal Blindness ◽  
Limbal Stem Cell ◽  
Cell Niche ◽  
The Right

Corneal failure is a highly prevalent cause of blindness. One special cause of corneal failure occurs due to malfunction or destruction of the limbal stem cell niche, upon which the superficial cornea depends for homeostatic maintenance and wound healing. Failure of the limbal niche is referred to as limbal stem cell deficiency. As the corneal epithelial stem cell niche is easily accessible, limbal stem cell-based therapy and regenerative medicine applied to the ocular surface are among the most highly advanced forms of this novel approach to disease therapy. However, the challenges are still great, including the development of cell-based products and understanding how they work in the patient’s eye. Advances are being made at the molecular, cellular, and tissue levels to alter disease processes and to reduce or eliminate blindness. Efforts must be coordinated from the most basic research to the most clinically oriented projects so that cell-based therapies can become an integrated part of the therapeutic armamentarium to fight corneal blindness. We undoubtedly are progressing along the right path because cell-based therapy for eye diseases is one of the most successful examples of global regenerative medicine.

Skin regenerative medicine advancements in the Islamic Republic of Iran: a concise review

2019 ◽  
Vol 14 (11) ◽  
pp. 1047-1056
Author(s):  
Mohammad Ali Nilforoushzadeh ◽  
Mohammad Amir Amirkhani ◽  
Amir Ali Hamidieh ◽  
Alexander M Seifalian ◽  
Mahsa Mollapour Sisakht
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Historical Overview ◽  
Islamic Republic ◽  
Stem Cell Technology ◽  
The Past ◽  
Concise Review ◽  
Regulatory Approach ◽  
Islamic Republic Of Iran ◽  
Research Frameworks

In the last decade, the Islamic Republic of Iran has witnessed significant improvement and growth in the field of interdisciplinary medicine and in its translation to patients, including the field of cell and stem cell therapy. The main aim of this report is to highlight various advances in regenerative medicine for skin and dermatology using stem cell technology, and its translation to clinic in the past two decades, in Iranian academic centers, clinical institutes and hospitals. While there have been numerous positive advances in clinical outcomes reported in Iran, there is no comparative analytical information on these studies. Here we present a historical overview of the progress and key advancements seen in skin regeneration in this country, review the research frameworks, regulatory approach and pathways and offer perspectives for the future.

A Concise Review on Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Personalized Regenerative Medicine

2020 ◽  
Author(s):  
Pallavi Pushp ◽  
Diogo E. S. Nogueira ◽  
Carlos A. V. Rodrigues ◽  
Frederico C. Ferreira ◽  
Joaquim M. S. Cabral ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Pluripotent Stem Cell ◽  
Induced Pluripotent Stem Cell ◽  
Concise Review ◽  
Induced Pluripotent

scholarly journals Concise Review: Tailoring Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine

2015 ◽  
Vol 4 (2) ◽  
pp. 156-164 ◽  
Author(s):  
Steffen Cosson ◽  
Ellen A. Otte ◽  
Hadi Hezaveh ◽  
Justin J. Cooper-White
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Concise Review

scholarly journals Concise Review: Unraveling Stem Cell Cocultures in Regenerative Medicine: Which Cell Interactions Steer Cartilage Regeneration and How?

2014 ◽  
Vol 3 (6) ◽  
pp. 723-733 ◽  
Author(s):  
Tommy S. de Windt ◽  
Jeanine A.A. Hendriks ◽  
Xing Zhao ◽  
Lucienne A. Vonk ◽  
Laura B. Creemers ◽  
...  
Keyword(s):  
Stem Cell ◽  
Regenerative Medicine ◽  
Cartilage Regeneration ◽  
Cell Interactions ◽  
Concise Review

scholarly journals Mini-Review: Regenerating the Corneal Epithelium With Simple Limbal Epithelial Transplantation

2021 ◽  
Vol 8 ◽  
Author(s):  
Aastha Singh ◽  
Virender S. Sangwan
Keyword(s):  
Stem Cell ◽  
Low Cost ◽  
Effective Technique ◽  
Concise Review ◽  
Maximum Benefit ◽  
Clinical Scenarios ◽  
The World ◽  
Limbal Stem Cell Transplantation ◽  
Limbal Stem Cell ◽  
Work Up

Simple limbal epithelial transplantation (SLET) is an ingenious, low cost and effective technique of limbal stem cell transplantation (LSCT) that is increasingly being undertaken in practice across the world. Since it was first described a decade ago, the technique has been performed in a variety of cases of limbal stem cell deficiency (LSCD) and has underwent several innovative modifications. Published literature on SLET has progressively increased over time and successful outcomes in various clinical scenarios have been reported. This concise review attempts to present a crisp account of SLET covering the indications and contraindications of performing the procedure; detailed account of pre-operative work up and preparation; surgical technique and its modifications; post-operative course, care and possible complications as well as published outcomes of surgery from across the world. Comparative analysis of various techniques of LSCT have been discussed and common concerns of surgeons practising or those who are planning to start practising SLET have been addressed. The authors hope that the pragmatic insights and pearls given at the end of the review will aid the surgeons in performing this technique to provide maximum benefit to patients suffering from the potentially blinding condition of LSCD.

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