Faculty Opinions recommendation of A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells.

Key Points LUBAC elements HOIP and SHARPIN participate in T-cell receptor-mediated NF-κB activation independently of HOIP catalytic activity. LUBAC silencing compromises constitutive NF-κB activation and cell survival in ABC DLBCL lines.

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NF-ATc2 induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptor

European Journal of Immunology ◽

10.1002/immu.200390000 ◽

2003 ◽

Vol 33 (1) ◽

pp. 1-11 ◽

Cited By ~ 22

Author(s):

Eisaku Kondo ◽

Akira Harashima ◽

Takami Takabatake ◽

Hideo Takahashi ◽

Yoshinobu Matsuo ◽

...

Keyword(s):

B Cell ◽

Antigen Receptor ◽

Burkitt’S Lymphoma ◽

Burkitt's Lymphoma ◽

B Cell Antigen Receptor ◽

Lymphoma Cells ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Burkitt’S Lymphoma Cells

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Prolactin Receptor Signaling: Shared Components with the T-Cell Antigen Receptor in Nb2 Lymphoma Cells

Endocrine ◽

10.1385/endo:9:3:313 ◽

1998 ◽

Vol 9 (3) ◽

pp. 313-320 ◽

Cited By ~ 14

Author(s):

Joshua S. Krumenacker ◽

David W. Montgomery ◽

Donna J. Buckley ◽

Peter W. Gout ◽

Arthur R. Buckley

Keyword(s):

T Cell ◽

Prolactin Receptor ◽

Antigen Receptor ◽

Receptor Signaling ◽

Lymphoma Cells ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen

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Ultrastructural changes in murine lymphoma cells exposed to ultraviolet-A radiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010008482x ◽

1991 ◽

Vol 49 ◽

pp. 104-105

Author(s):

Delma P. Thomas ◽

Dianne E. Godar

Keyword(s):

Medical Devices ◽

Blood Cells ◽

White Blood Cells ◽

Consumer Products ◽

Ultrastructural Changes ◽

Ultraviolet A ◽

Uv Spectrum ◽

Lymphoma Cells ◽

Murine Lymphoma ◽

Transmission Electron

Ultraviolet radiation (UVR) from all three waveband regions of the UV spectrum, UVA (320-400 nm), UVB (290-320 nm), and UVC (200-290 nm), can be emitted by some medical devices and consumer products. Sunlamps can expose the blood to a considerable amount of UVR, particularly UVA and/or UVB. The percent transmission of each waveband through the epidermis to the dermis, which contains blood, increases in the order of increasing wavelength: UVC (10%) < UVB (20%) < UVA (30%). To investigate the effects of UVR on white blood cells, we chose transmission electron microscopy to examine the ultrastructure changes in L5178Y-R murine lymphoma cells.

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Duffy antigen / receptor for chemokines correlates with inflammatory reaction in rats with venous hypertension: implication for the pathogenesis of primary chronic venous disease

VASA ◽

10.1024/0301-1526/a000327 ◽

2014 ◽

Vol 43 (1) ◽

pp. 47-54 ◽

Cited By ~ 1

Author(s):

Weibin Huang ◽

Weiwei Qin ◽

Lei Lv ◽

Haoyv Deng ◽

Hao Zhang ◽

...

Keyword(s):

Mononuclear Cells ◽

Early Stage ◽

Antigen Receptor ◽

Venous Hypertension ◽

Skin Tissue ◽

Chronic Venous Disease ◽

Venous Disease ◽

Dependent Manner ◽

Time Points ◽

Duffy Antigen

Background: Duffy antigen / receptor for chemokines (DARC) possesses high affinity for several chemokine subgroups of CC and CXC. Although DARC has been shown to play a role in many inflammatory diseases, its effect on chronic venous disease (CVD) remains unidentified. We explored whether the expression of DARC in skin tissue was activated under venous hypertension as well as the relationships between DARC and inflammation. Materials and methods: The inflammation in a rat model of venous hypertension caused by a femoral arterial-venous fistula (AVF) was studied. At specified intervals the pressure in the femoral veins was recorded within 42 days. Hindlimb skin specimens were harvested at different time points. The expressions of DARC, interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1) in skin tissue were examined. Mononuclear cells infiltrated in skin tissue were detected. Results: Femoral venous pressures in AVF groups increased significantly at different time points (P < 0.01). DARC was expressed in skin tissue and its expression level increased significantly in AVF groups from the 7nd day on and was enhanced in a time-dependent manner within 42 days (P < 0.05). Meanwhile, both MCP-1 and IL-8 had higher levels, accompanied by increased mononuclear cells infiltrating into skin tissue (P < 0.05). Conclusions: A rat AVF model which can maintain venous hypertension for at least 42 days is competent for researching the pathogenesis of CVD. DARC, which plays a role in the inflammation of skin tissue under venous hypertension, may become a new molecular target for diagnosis and treatment of CVD at a very early stage.

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