Faculty Opinions recommendation of Delayed coupling to feedback inhibition during a critical period for the integration of adult-born granule cells.

2019 ◽  
Author(s):  
Linda Overstreet-Wadiche ◽  
Jose Gonzalez
Keyword(s):  
Critical Period ◽  
Granule Cells ◽  
Feedback Inhibition ◽  
Delayed Coupling

scholarly journals Delayed Coupling to Feedback Inhibition during a Critical Period for the Integration of Adult-Born Granule Cells

Neuron ◽  
2015 ◽  
Vol 85 (1) ◽  
pp. 116-130 ◽  
Author(s):  
Silvio G. Temprana ◽  
Lucas A. Mongiat ◽  
Sung M. Yang ◽  
Mariela F. Trinchero ◽  
Diego D. Alvarez ◽  
...  
Keyword(s):  
Critical Period ◽  
Granule Cells ◽  
Feedback Inhibition ◽  
Delayed Coupling

scholarly journals Dendritic Morphology and Inhibitory Regulation Distinguish Dentate Semilunar Granule Cells from Granule Cells through Distinct Stages of Postnatal Development

2019 ◽  
Author(s):  
Akshay Gupta ◽  
Archana Proddutur ◽  
Yun-Juan Chang ◽  
Vidhatri Raturi ◽  
Jenieve Guevarra ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Granule Cells ◽  
Feedback Inhibition ◽  
Input Resistance ◽  
Cell Types ◽  
Structural Features ◽  
Dendritic Morphology ◽  
Membrane Properties ◽  
Projection Neurons ◽  
Inhibitory Regulation

AbstractSemilunar granule cells (SGCs) have been proposed as a morpho-functionally distinct class of hippocampal dentate projection neurons contributing to feedback inhibition and memory processing in juvenile rats. However, the structural and physiological features that can reliably classify granule cells (GCs) from SGCs through postnatal development remain unresolved. Focusing on postnatal days 11-13, 28-42, and >120, corresponding with human infancy, adolescence, and adulthood, we examined the somatodendritic morphology and inhibitory regulation in SGCs and GCs to determine the cell-type specific features. Unsupervised cluster analysis confirmed that morphological features reliably distinguish SGCs from GCs irrespective of animal age. SGCs maintain higher spontaneous inhibitory postsynaptic current (sIPSC) frequency than GCs from infancy through adulthood. Although sIPSC frequency in SGCs was particularly enhanced during adolescence, sIPSC amplitude and cumulative charge transfer declined from infancy to adulthood and were not different between GCs and SGCs. Extrasynaptic GABA current amplitude peaked in adolescence in both cell types and was significantly greater in SGCs than in GCs only during adolescence. Although GC input resistance was higher than in SGCs during infancy and adolescence, input resistance decreased with developmental age in GCs while it progressively increased in SGCs. Consequently, GCs input resistance was significantly lower than SGCs in adults. The data delineate the structural features that can reliably distinguish GCs from SGCs through development. The results reveal developmental differences in passive membrane properties and steady state inhibition between GCs and SGCs which could confound their use in classifying the cell types.

Adult-born dentate granule cells show a critical period of dendritic reorganization and are distinct from developmentally born cells

2016 ◽  
Vol 222 (3) ◽  
pp. 1427-1446 ◽  
Author(s):  
Marcel Beining ◽  
Tassilo Jungenitz ◽  
Tijana Radic ◽  
Thomas Deller ◽  
Hermann Cuntz ◽  
...  
Keyword(s):  
Critical Period ◽  
Granule Cells ◽  
Dentate Granule Cells

scholarly journals Sensory experience inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Nathaniel J Miska ◽  
Leonidas MA Richter ◽  
Brian A Cary ◽  
Julijana Gjorgjieva ◽  
Gina G Turrigiano
Keyword(s):  
Visual Cortex ◽  
Driving Force ◽  
Critical Period ◽  
Visual Experience ◽  
Feedback Inhibition ◽  
Intracortical Inhibition ◽  
Monocular Deprivation ◽  
Long Term Depression ◽  
Layer 4

Brief (2-3d) monocular deprivation (MD) during the critical period induces a profound loss of responsiveness within binocular (V1b) and monocular (V1m) regions of rodent primary visual cortex. This has largely been ascribed to long-term depression (LTD) at thalamocortical synapses, while a contribution from intracortical inhibition has been controversial. Here we used optogenetics to isolate and measure feedforward thalamocortical and feedback intracortical excitation-inhibition (E-I) ratios following brief MD. Despite depression at thalamocortical synapses, thalamocortical E-I ratio was unaffected in V1b and shifted toward excitation in V1m, indicating that thalamocortical excitation was not effectively reduced. In contrast, feedback intracortical E-I ratio was shifted toward inhibition in V1m, and a computational model demonstrated that these opposing shifts produced an overall suppression of layer 4 excitability. Thus, feedforward and feedback E-I ratios can be independently tuned by visual experience, and enhanced feedback inhibition is the primary driving force behind loss of visual responsiveness.

scholarly journals Sensory Deprivation Independently Regulates Neocortical Feedforward and Feedback Excitation-Inhibition Ratio

2018 ◽  
Author(s):  
Nathaniel J. Miska ◽  
Leonidas M.A. Richter ◽  
Brian A. Cary ◽  
Julijana Gjorgjieva ◽  
Gina G. Turrigiano
Keyword(s):  
Critical Period ◽  
Visual Experience ◽  
Pyramidal Neurons ◽  
Feedback Inhibition ◽  
Sensory Deprivation ◽  
Intracortical Inhibition ◽  
Monocular Deprivation ◽  
Layer 4 ◽  
Postsynaptic Target

SUMMARYBrief (2-3d) monocular deprivation (MD) during the critical period induces a profound loss of responsiveness within layer 4 of primary visual cortex (V1). This has largely been ascribed to long-term depression (LTD) at thalamocortical synapses onto pyramidal neurons, while a contribution from intracortical inhibition has been controversial. Here we used optogenetics to probe feedforward thalamocortical and feedback intracortical excitation-inhibition (E-I) ratios following brief MD. While thalamocortical inputs onto pyramidal neurons were depressed, there was stronger depression onto PV+ interneurons, which shifted the thalamocortical-evoked E-I ratio toward excitation. In contrast, feedback intracortical E-I ratio was shifted toward inhibition, and a computational model of layer 4 demonstrated that these opposing shifts produced an overall suppression of layer 4 excitability. Thus, feedforward and feedback E-I ratios onto the same postsynaptic target can be independently regulated by visual experience, and enhanced feedback inhibition is the primary driving force behind loss of visual responsiveness.

scholarly journals Differential Activity-Dependent Scaling of Synaptic Inhibition and Parvalbumin Interneuron Recruitment in Dentate Projection Neuron Subtypes

2021 ◽  
Author(s):  
Milad Afrasiabi ◽  
AKSHAY - GUPTA ◽  
Huaying Xu ◽  
Bogumil Swietek ◽  
Vijayalakshmi Santhakumar
Keyword(s):  
Granule Cells ◽  
Feedback Inhibition ◽  
Projection Neuron ◽  
Network Activity ◽  
Perforant Path ◽  
Synaptic Inhibition ◽  
Parvalbumin Interneuron ◽  
Fast Spiking ◽  
Activity Dependent ◽  
Kinetics Of

Strong inhibitory synaptic gating of dentate gyrus granule cells (GCs), attributed largely to fast-spiking parvalbumin interneurons (PV-INs), is essential to maintain sparse network activity needed for dentate dependent behaviors. However, the contribution of PV-INs to basal and input driven sustained synaptic inhibition in GCs and semilunar granule cells (SGCs), a sparse morphologically distinct dentate projection neuron subtype are currently unknown. We find that although basal inhibitory postsynaptic currents (IPSCs) are more frequent in SGCs and optical activation of PV-INs elicited IPSCs in both GCs and SGCs, optical suppression of PV-INs failed to reduce IPSC frequency in either cell type. Amplitude and kinetics of IPSCs evoked by perforant path activation were not different between GCs and SGCs. However, the robust increase in sustained polysynaptic IPSCs elicited by paired afferent stimulation was lower in SGCs than in simultaneously recorded GCs. Optical suppression of PV-IN selectively reduced sustained IPSCs in SGCs but not in GCs. These results demonstrate that PV-INs, while contributing minimally to basal synaptic inhibition in both GCs and SGCs in slices, mediate sustained feedback inhibition selectively in SGCs. The temporally selective blunting of activity-driven sustained inhibitory gating of SGCs could support their preferential and persistent recruitment during behavioral tasks.

scholarly journals Cerebellar connectivity maps embody individual adaptive behavior

2021 ◽  
Author(s):  
Ludovic Spaeth ◽  
Jyotika Bahuguna ◽  
Theo Gagneux ◽  
Kevin Dorgans ◽  
Izumi Sugihara ◽  
...  
Keyword(s):  
Critical Period ◽  
Spatial Organization ◽  
Granule Cells ◽  
Functional Organization ◽  
Motor Adaptation ◽  
Synaptic Connectivity ◽  
General Motor ◽  
Behavioral Features ◽  
Specific Manner ◽  
Context Specific

AbstractFrom planification to execution, cerebellar microcircuits encode different features of skilled movements. However, it is unknown whether cerebellar synaptic connectivity maps encode movement features in a motor context specific manner. Here we investigated the spatial organization of excitatory synaptic connectivity in mice cerebellar cortex in different locomotor contexts: during development and in normal, trained or altered locomotor conditions. We combined optical, electrophysiological and graph modelling approaches to describe synaptic connectivity between granule cells (GCs) and Purkinje cells (PCs). Synaptic map maturation during development revealed a critical period in juvenile animals before the establishment of a stereotyped functional organization in adults. However, different locomotor conditions lead to specific GC-PC connectivity maps in PCs. Ultimately, we demonstrated that the variability in connectivity maps directly accounts for individual specific behavioral features of mice locomotion, suggesting that GC-PC networks encode a general motor context as well as individual specific internal models underlying motor adaptation.

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