Faculty Opinions recommendation of Growth factor pathways in hypertrophic scars: Molecular pathogenesis and therapeutic implications.

2019 ◽  
Author(s):  
Taina Pihlajaniemi ◽  
Ritva Heljasvaara
Keyword(s):  
Growth Factor ◽  
Molecular Pathogenesis ◽  
Hypertrophic Scars ◽  
Therapeutic Implications ◽  
Growth Factor Pathways

Advances in molecular pathogenesis thyroid cancer: therapeutic implications

2014 ◽  
Author(s):  
Pilar Santisteban ◽  
Ana Sastre-Perona ◽  
Leon Wert-Lamas ◽  
Garcilaso Riesco-Eizaguirre
Keyword(s):  
Thyroid Cancer ◽  
Molecular Pathogenesis ◽  
Therapeutic Implications

Dynamic Expression of TRPV3 and Integrated Signaling with Growth Factor Pathways During Lung Epithelial Wound Repair Following Wood Smoke Particle and Other Forms of Lung Cell Injury

2021 ◽  
pp. MOLPHARM-AR-2021-000280
Author(s):  
Katherine L. Burrell ◽  
Nam D. Nguyen ◽  
Cassandra E. Deering-Rice ◽  
Tosifa A. Memon ◽  
Marysol Almestica-Roberts ◽  
...  
Keyword(s):  
Growth Factor ◽  
Wound Repair ◽  
Cell Injury ◽  
Wood Smoke ◽  
Smoke Particle ◽  
Dynamic Expression ◽  
Lung Epithelial ◽  
Growth Factor Pathways

scholarly journals Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis

1999 ◽  
Vol 277 (4) ◽  
pp. L684-L693 ◽  
Author(s):  
Christine L. Zanella ◽  
Cynthia R. Timblin ◽  
Andrew Cummins ◽  
Michael Jung ◽  
Jonathan Goldberg ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Egf Receptor ◽  
Growth Factor Receptor ◽  
Direct Interaction ◽  
Mrna Levels ◽  
Binding Studies ◽  
Therapeutic Implications ◽  
Asbestos Fibers ◽  
Epidermal Growth

We examined the mechanisms of interaction of crocidolite asbestos fibers with the epidermal growth factor (EGF) receptor (EGFR) and the role of the EGFR-extracellular signal-regulated kinase (ERK) signaling pathway in early-response protooncogene (c- fos/c- jun) expression and apoptosis induced by asbestos in rat pleural mesothelial (RPM) cells. Asbestos fibers, but not the nonfibrous analog riebeckite, abolished binding of EGF to the EGFR. This was not due to a direct interaction of fibers with ligand, inasmuch as binding studies using fibers and EGF in the absence of membranes showed that EGF did not adsorb to the surface of asbestos fibers. Exposure of RPM cells to asbestos caused a greater than twofold increase in steady-state message and protein levels of EGFR ( P < 0.05). The tyrphostin AG-1478, which inhibits the tyrosine kinase activity of the EGFR, but not the tyrphostin A-10, which does not affect EGFR activity, significantly ameliorated asbestos-induced increases in mRNA levels of c- fos but not of c- jun. Pretreatment of RPM cells with AG-1478 significantly reduced apoptosis in cells exposed to asbestos. Our findings suggest that asbestos-induced binding to EGFR initiates signaling pathways responsible for increased expression of the protooncogene c- fos and the development of apoptosis. The ability to block asbestos-induced elevations in c- fos mRNA levels and apoptosis by small-molecule inhibitors of EGFR phosphorylation may have therapeutic implications in asbestos-related diseases.

The role of transforming growth factor β in glaucoma and the therapeutic implications

2013 ◽  
Vol 97 (6) ◽  
pp. 680-686 ◽  
Author(s):  
Mark A Prendes ◽  
Alon Harris ◽  
Barbara M Wirostko ◽  
Austin L Gerber ◽  
Brent Siesky
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Therapeutic Implications

scholarly journals Therapeutic implications of fibroblast growth factor receptor inhibitors in a combination regimen for solid tumors (Review)

2020 ◽  
Vol 20 (3) ◽  
pp. 2525-2536
Author(s):  
Hong Luo ◽  
Tao Zhang ◽  
Peng Cheng ◽  
Dong Li ◽  
Oleksandr Ogorodniitchouk ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Solid Tumors ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Combination Regimen ◽  
Fibroblast Growth ◽  
Therapeutic Implications
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