Faculty Opinions recommendation of Understanding the role of Propionibacterium acnes in acne vulgaris: The critical importance of skin sampling methodologies.

2018 ◽  
Author(s):  
Clio Dessinioti
Keyword(s):  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Critical Importance

scholarly journals The Role of Digital Fluorescence in Acne Vulgaris: Correlation of Ultraviolet Red Fluorescence with the Severity of Acne Vulgaris

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Imam Budi Putra ◽  
Nelva K. Jusuf ◽  
Nani Kumala Dewi
Keyword(s):  
Propionibacterium Acnes ◽  
Acne Vulgaris ◽  
Severe Acne ◽  
Red Fluorescence ◽  
Acne Lesion ◽  
Percentage Area ◽  
Sebum Production ◽  
Spearman Test

Background. Colonization of Propionibacterium acnes (P. acnes) and increased sebum production play important roles in the pathogenesis of acne vulgaris. Severity of acne vulgaris correlates with the lesion counts both noninflammatory and inflammatory. Digital fluorescence has been found useful in pathogenesis investigation and treatment evaluation. Ultraviolet-induced red fluorescence (UVRF) was found to be correlated with sebum and porphyrin production that can be synthesized by P. acnes. Therefore, UVRF assessment could be useful for the evaluation of the degree and extent of acne vulgaris. Objective. To evaluate the correlation of UVRF with the severity of acne vulgaris using the digital fluorescence tool. Methods. Forty-five patients were diagnosed with mild-to-severe acne vulgaris according to Lehmann classification. Lesion counts both noninflammatory and inflammatory and UVRF assessment using Visiopor PP34 camera were done to all participants in 5 divided facial areas (forehead, nose, right and left cheeks, and chin). Clinical assessment for each patient was done by 3 dermatologists. Determination of correlation between UVRF with acne lesion counts was done using Pearson test and with acne severity using Spearman test. Results. From 45 participants, majority had moderate acne (64.4%), followed by severe (24.5%) and mild acne (11.1%). Mean number of UVRF spots was 39.98 ± 11.45 and percentage area covered with UVRF was 4.39 ± 1.72. There was no correlation found between acne lesion counts, including noninflammatory and inflammatory with the number and percentage area covered with UVRF spots. Severity grade of acne vulgaris was found to be uncorrelated with the number of UVRF spots (r = 0.27, p=0.073) and percentage area covered with UVRF spots (r = 0.173, p=0.256). Conclusion. The severity of acne vulgaris has no correlation with spot counts and percentage area covered with UVRF. Digital fluorescence might be helpful in investigating further of the interrelated pathogenesis factors of acne.

scholarly journals Assessment of efficacy and safety of dapsone gel 5% in the treatment of acne vulgaris

2019 ◽  
Vol 15 (1) ◽  
pp. 136-162
Author(s):  
Yasir Mansour Al-Ani
Keyword(s):  
Propionibacterium Acnes ◽  
Skin Diseases ◽  
Acne Vulgaris ◽  
Innate Immune ◽  
Matrix Remodeling ◽  
Sebaceous Glands ◽  
Social Ostracism ◽  
Recent Laboratory

ABSTRACTBackground : Acne vulgaris is acommon skin disease, affecting more than 85% ofadolescents and often continuing into adulthood.People between 11 and 30 years of age and up to5% of older adults. For most patients acne remainsa nuisance with occasional flares of unsightlycomedones, pustules and nodules. For other lessfortunate persons, the sever inflammatory responseto Propionibacterium acnes (P.acnes) results inpermanentMethods: Disfiguring scars. (1, 2) Stigmata of severacne cane lead to social ostracism, withdrawalfrom society and severe psychologicdepression (1-4).Result Pathogenesis of acne Traditionally, acnehas been thought of as a multifactorial disease ofthe folliculosebaceous unit, involving excesssebum production, abnormal follicularhyperkeratinization, overgrowth ofPropionibacterium acnes, and inflammation (Fig2). Recent laboratory and clinical investigationsinto the roles of the innate immune system andextracellular matrix remodeling proteins have shedadditional light on this pathogenetic process (5-7).Role of androgens: Activity of type 1 5areductaseenzyme was shown to predominate inhuman sebaceous glands and epidermis. Thisenzyme is responsible for the conversion oftestosterone to the more potent androgen,dihydrotestosterone (DHT). DHT in turn is thoughtto mediate androgen dependent skin diseases suchas acne, hirsutism and androgenetic alopecia (13)The enzyme 5a-reductase type 1 has been studiedin those with and without acne and it has beenhypothesized that those with acne might have moreactive 5a-reductase type 1 .(2)Conclusion : The prominent role of hormones inthe pathophysiology of acne has long beenrecognized and corroborated by clinical andexperimental observations and therapeuticexperience (14). Although acne is not considered aprimary endocrine disorder, androgens, such asdihydrotestosterone, dehydroepiandrosteronesulfate, and testosterone, and growth hormone andinsulin-like growth factors, have all beenimplicated in the pathogenesis of acne (15).Corresponding address to :Dr. Yasir Mansour Mohamed Al-AniIslam Mohammad Nabil El Helou

Citrula Gel dari Limbah Kulit Buah Semangka (Citrullus lanatus (Thunb.) Matsum & Nakai) sebagai Antijerawat (Acne vulgaris)

2019 ◽  
Vol 16 (1) ◽  
pp. 74
Author(s):  
Yola Anggraeni ◽  
Tika Ambarwati ◽  
Irmas Miranti ◽  
Erza Genatrika
Keyword(s):  
Staphylococcus Aureus ◽  
Propionibacterium Acnes ◽  
Citrullus Lanatus ◽  
Acne Vulgaris ◽  
Carbopol 940

Jerawat  didefinisikan  sebagai  peradangan  kronik  dari  folikel  polisebasea  yang disebabkan  oleh  beberapa  faktor  dengan  gambaran  klinis  yang  khas.  Salah  satu tanaman  yang  dapat  mengatasi  jerawat  yaitu semangka.  Kulit buah semangka (Citrullus lanatus (Thunb.) Matsum & Nakai) memiliki   senyawa antibakteri di antaranya  alkaloid,  fenol,  saponin,  dan  terpenoid.  Dalam penelitian ini ekstrak limbah  kulit  buah semangka diformulasikan   dalam   sediaan   gel.   Tahap   penelitian   yang menggunakan  rancangan  acak  lengkap ini meliputi  penyiapan  dan  pengumpulan simplisia   limbah   kulit   buah   semangka,   ekstraksi,   uji kandungan senyawa, formulasi gel, evaluasi sifat fisik sediaan gel, dan uji aktivitas antibakteri  terhadap  bakteri  Propionibacterium acnes  dan  Staphylococcus  aureus. Ekstraksi yang dilakukan adalah dengan menggunakan metode maserasi dengan penyari kloroform. Uji kandungan senyawa dilakukan dengan menggunakan metode penapisan fitokimia meliputi uji alkaloid, uji triterpenoid, uji fenol, dan uji saponin. Ekstrak kulit buah semangka dengan konsentrasi 5, 10, dan 15% kemudian diformulasikan dengan carbopol 940 dan dilanjutkan dengan evaluasi sifat fisik gel, di antaranya uji organoleptis, uji homogenitas, uji daya sebar, uji daya lekat, uji pH, dan uji viskositas. Uji aktivitas antibakteri dari formulasi ekstrak kulit buah semangka dilakukan dengan menggunakan metode difusi agar. Hasil formulasi terbaik pada formulasi gel menghasilkan gel yang homogen, lekat, menyebar, pH yang cocok dengan kulit, dan memiliki viskositas yang cukup baik. Hasil terbaik dari zona hambat uji antibakteri pada bakteri Propionibacterium acnes yaitu 5,23 mm dan pada bakteri Staphylococcus  aureus yaitu 5,80 mm.

Assessment of the role of T Helper 17 cells in the pathogenesis of Acne Vulgaris

2019 ◽  
Vol 10 (12) ◽  
pp. 1435
Author(s):  
Nahla Maher ◽  
HebatAllah Ismail Gawdat ◽  
Heba Helmy El Hadidi ◽  
Olfat Gamil Shaker
Keyword(s):  
Acne Vulgaris ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells

scholarly journals Pro-Inflammatory and Neurotrophic Factor Responses of Cells Derived from Degenerative Human Intervertebral Discs to the Opportunistic Pathogen Cutibacterium acnes

2021 ◽  
Vol 22 (5) ◽  
pp. 2347
Author(s):  
Manu N. Capoor ◽  
Anna Konieczna ◽  
Andrew McDowell ◽  
Filip Ruzicka ◽  
Martin Smrcka ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Acne Vulgaris ◽  
Opportunistic Pathogen ◽  
Intervertebral Discs ◽  
Disc Disease ◽  
Gene Target ◽  
Cutibacterium Acnes ◽  
Pre Treatment

Previously, we proposed the hypothesis that similarities in the inflammatory response observed in acne vulgaris and degenerative disc disease (DDD), especially the central role of interleukin (IL)-1β, may be further evidence of the role of the anaerobic bacterium Cutibacterium (previously Propionibacterium) acnes in the underlying aetiology of disc degeneration. To investigate this, we examined the upregulation of IL-1β, and other known IL-1β-induced inflammatory markers and neurotrophic factors, from nucleus-pulposus-derived disc cells infected in vitro with C. acnes for up to 48 h. Upon infection, significant upregulation of IL-1β, alongside IL-6, IL-8, chemokine (C-C motif) ligand 3 (CCL3), chemokine (C-C motif) ligand 4 (CCL4), nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), was observed with cells isolated from the degenerative discs of eight patients versus non-infected controls. Expression levels did, however, depend on gene target, multiplicity and period of infection and, notably, donor response. Pre-treatment of cells with clindamycin prior to infection significantly reduced the production of pro-inflammatory mediators. This study confirms that C. acnes can stimulate the expression of IL-1β and other host molecules previously associated with pathological changes in disc tissue, including neo-innervation. While still controversial, the role of C. acnes in DDD remains biologically credible, and its ability to cause disease likely reflects a combination of factors, particularly individualised response to infection.

scholarly journals Will the Consequences of Covid-19 Trigger a Redefining of the Role of Transport in the Development of Sustainable Tourism?

2021 ◽  
Vol 13 (4) ◽  
pp. 1887
Author(s):  
Marek Więckowski
Keyword(s):  
Sustainable Development ◽  
Literature Review ◽  
Sustainable Transport ◽  
Critical Importance ◽  
Global Issues ◽  
Changing Roles ◽  
Sustainable Utilisation ◽  
Tourism Enterprises ◽  
Critical Overview

As there are very marked relationships between tourism and transport, integrated knowledge of these processes is essential if destinations and tourism enterprises are to be developed, an effective tourism policy pursued, and emerging local and global issues and conflicts surrounding tourism resolved. Beyond this, in an era of huge change reflecting the consequences of the COVID-19 viral pandemic, the importance of sustainable transport in tourism’s sustainable development appears to be of critical importance. Adopting this kind of perspective, this paper seeks to achieve a critical overview of conceptual dimensions of sustainability that link up with tourism and transport. To this end, ideas based on the literature and previous discussions are extended to include certain new propositions arising out of a (hopefully) post-COVID-19 world. Proceeding first with a systematic literature review (SLR), this article discusses the importance of transport to the development of tourism, dealing critically with modes of transport and their changing roles in sustainable development under COVID and post-COVID circumstances. The author summarises likely new way(s) of thinking in the aftermath of the pandemic, with the need for this/these to be far more sustainable and responsible, and characterised by a reorientation of behaviour in a “green” direction. It is further concluded that three aspects of transport–tourism relations will prove crucial to more sustainable utilisation—i.e., proximity, slower and less energy-intensive travel, and green transport.

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