Faculty Opinions recommendation of Mechanism of ICU-acquired weakness: skeletal muscle loss in critical illness.

Author(s):  
Nicola Latronico
2017 ◽  
Vol 43 (12) ◽  
pp. 1844-1846 ◽  
Author(s):  
Jane Batt ◽  
Margaret Herridge ◽  
Claudia dos Santos

Author(s):  
Catherine L Hough

Patients with critical illness are at risk of profound weakness and skeletal muscle loss, and recovery is marked by prolonged physical functional impairment in many survivors. Muscle and nerve abnormalities found in critically ill patients include loss of muscle mass, muscle membrane inexcitability, polyneuropathy, mitochondrial dysfunction with bioenergetic failure, as well as changes in skeletal muscle structure. The most common histological abnormalities are atrophy of both type I and II fibres and thick filament loss; muscle necrosis is less common. While recent studies have illuminated the pathogenesis of critical illness myopathy, additional high-quality translational research is needed to identify targets for therapeutic intervention.


2018 ◽  
Vol 46 (4) ◽  
pp. 311-315 ◽  
Author(s):  
Jehanzeb Khan ◽  
◽  
Khushbir Bath ◽  
Fareeha Hafeez ◽  
Gayoung Kim ◽  
...  

2010 ◽  
Vol 42 (6) ◽  
pp. 950-958 ◽  
Author(s):  
Flávia A. Guarnier ◽  
Alessandra L. Cecchini ◽  
Andréia A. Suzukawa ◽  
Ana Leticia G.C. Maragno ◽  
Andréa N.C. Simão ◽  
...  

2017 ◽  
Vol 25 (7) ◽  
pp. 2221-2227 ◽  
Author(s):  
Yoshiko Kubo ◽  
Tateaki Naito ◽  
Keita Mori ◽  
Gakuji Osawa ◽  
Etsuko Aruga

2018 ◽  
Vol 38 (10) ◽  
pp. 5859-5866 ◽  
Author(s):  
KEIJI SUGIYAMA ◽  
YUKIYA NARITA ◽  
SEIICHIRO MITANI ◽  
KAZUNORI HONDA ◽  
TOSHIKI MASUISHI ◽  
...  

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Naoaki Maeda ◽  
Yasuhiro Shirakawa ◽  
Shunsuke Tanabe ◽  
Kazufumi Sakurama ◽  
Kazuhiro Noma ◽  
...  

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