Faculty Opinions recommendation of Impact of an electronic sepsis initiative on antibiotic use and health care facility-onset Clostridium difficile infection rates.

2019 ◽  
Author(s):  
Pranavi Sreeramoju
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Care Facility ◽  
Health Care Facility ◽  
Antibiotic Use ◽  
Infection Rates

Impact of an electronic sepsis initiative on antibiotic use and health care facility–onset Clostridium difficile infection rates

2017 ◽  
Vol 45 (10) ◽  
pp. 1091-1100 ◽  
Author(s):  
Robert Hiensch ◽  
Jashvant Poeran ◽  
Patricia Saunders-Hao ◽  
Victoria Adams ◽  
Charles A. Powell ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Care Facility ◽  
Health Care Facility ◽  
Antibiotic Use ◽  
Infection Rates

Correlation between hospital-level antibiotic consumption and incident health care facility-onset Clostridium difficile infection

2018 ◽  
Vol 46 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Page E. Crew ◽  
Nathaniel J. Rhodes ◽  
J. Nicholas O'Donnell ◽  
Cristina Miglis ◽  
Elise M. Gilbert ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Care Facility ◽  
Health Care Facility ◽  
Antibiotic Consumption ◽  
Hospital Level

scholarly journals No Impact of Probiotics to Reduce Clostridium difficile Infection in Hospitalized Patients: A Real-world Experience

2018 ◽  
Vol 5 (12) ◽  
Author(s):  
Maggie J Box ◽  
Kristine N Ortwine ◽  
Miguel Goicoechea ◽  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Real World ◽  
Care Facility ◽  
Health Care Facility ◽  
Hospitalized Patients ◽  
P 16

Abstract We assessed the effectiveness of a Lactobacillus probiotic on rates of health care facility–onset Clostridium difficile infection (HO-CDI) in patients receiving antibiotics. A total of 1576 patients were evaluated. There was no difference in the HO-CDI incidence between those who received probiotics and those who did not (1.8% vs 0.9%; P = .16).

Analysis of two Clostridium difficile outbreaks in an acute health care facility

2016 ◽  
Vol 1 (2) ◽  
pp. 23-31
Author(s):  
Yanal M Murad ◽  
Justo Perez ◽  
Gustavo Ybazeta ◽  
Brenda Dewar ◽  
Sebastien Lefebvre ◽  
...  
Keyword(s):  
Health Care ◽  
Clostridium Difficile ◽  
Care Facility ◽  
Health Care Facility ◽  
Acute Health Care

scholarly journals Antibiotic Exposure and Risk for Hospital-Associated Clostridioides difficile Infection

2020 ◽  
Vol 64 (4) ◽  
Author(s):  
Brandon J. Webb ◽  
Aruna Subramanian ◽  
Bert Lopansri ◽  
Bruce Goodman ◽  
Peter Bjorn Jones ◽  
...  
Keyword(s):  
Health Care ◽  
Care Facility ◽  
Health Care Facility ◽  
Antibiotic Use ◽  
Antibiotic Exposure ◽  
Content Type ◽  
Clostridioides Difficile ◽  
Clostridioides Difficile Infection ◽  
Intermountain Healthcare ◽  
Health Care Associated Infection

ABSTRACT Clostridioides difficile infection (CDI) is a health care-associated infection associated with significant morbidity and cost, with highly varied risk across populations. More effective, risk-based prevention strategies are needed. Here, we investigate risk factors for hospital-associated CDI in a large integrated health system. In a retrospective cohort of all adult admissions to 21 Intermountain Healthcare hospitals from 2006 to 2012, we identified all symptomatic (i) hospital-onset and (ii) health care-facility-associated, community-onset CDI. We then evaluated the risk associated with antibiotic exposure, including that of specific agents, using multivariable logistic regression. A total of 2,356 cases of CDI among 506,068 admissions were identified (incidence, 46.6 per 10,000). Prior antibiotic use was the dominant risk factor, where for every antibiotic day of therapy prior to the index admission, the odds of subsequent CDI increased by 12.8% (95% confidence interval [CI], 12.2 to 13.4%; P < 0.0001). This was a much stronger association than was inpatient antibiotic exposure (odds ratio [OR], 1.007 [95% CI, 1.005 to 1.009]; P < 0.0001). The highest-risk antibiotics included second-generation and later cephalosporins (especially oral), carbapenems, fluoroquinolones, and clindamycin, while doxycycline and daptomycin were associated with a lower CDI risk. We concluded that cumulative antibiotic exposure prior to admission is the greatest contributor to the risk of subsequent CDI. Most classes of antibiotics carry some risk, which varies by drug and route. This information may be useful for antimicrobial stewardship efforts.

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