scholarly journals Faculty Opinions recommendation of Safety of discharge for children with cancer and febrile neutropenia off antibiotics using absolute neutrophil count threshold values as a surrogate marker for adequate bone marrow recovery.

Author(s):  
Bob Phillips
Blood ◽  
1961 ◽  
Vol 17 (2) ◽  
pp. 182-195 ◽  
Author(s):  
RICHARD K. SHAW ◽  
DANE R. BOGGS ◽  
HAROLD R. SILBERMAN ◽  
EMIL FREI

Abstract A study of prednisone therapy in 18 patients with chronic lymphocytic leukemia is reported. 1. Antileukemic effects consisting of subjective improvement, decrease in organ infiltration, improvement in hemoglobulin and absolute neutrophil count occurred. 2. These effects were transient. 3. An increase, often marked, in the number of circulating lymphocytes occurred in 16 of the 18 patients. 4. The administration of prednisone was attended by an increase in the severity of infections. Some increase in the frequency of infections was also observed, but this was not statistically significant (p > 0.05). It is concluded that corticosteroids should not be used electively in patients with chronic lymphocytic leukemia except in the presence of hemolytic anemia, significant thrombocytopenia or in the presence of advanced disease associated with bone marrow failure.


2016 ◽  
Vol 10 (3) ◽  
pp. 596-599 ◽  
Author(s):  
Gustavo Gomez ◽  
Shifa Umar ◽  
Mohammad Bilal ◽  
Cristina Strahotin ◽  
Kofi Clarke

A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.


2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Anita Rahmawati ◽  
Pearla Lasut

Abstract: Febrile neutropenia is found in 10-50% of post chemotherapy patients with solid tumor and in more than 80% of patients with hematological malignancy. We reported a case of febrile neutropenia, local chemoport infection, and right breast cancer on chemoterapy in a 47-year-old female. Diagnosis was based on symptoms, clinical features, and laboratory examina-tion with absolute neutrophil count (ANC) 460 cells/mm3. This patient was treated with IVFD NaCl 0.9% 20 drops/minute, ceftazidime 2 g every 8 hour intravenous, and filgastrim 300 mcg every 24 hours subcutan. The prognosis of this patient was as follows: ad vitam was dubia ad malam, ad functionam was dubia ad bonam, and ad sanationam was dubia.Keywords: febrile neutropenia, post chemotherapy Abstrak: Febrile neutropenia terjadi pada 10-50% pasien pasca kemoterapi dengan tumor padat dan lebih dari 80% pasien pasca kemoterapi dengan keganasan hematologik. Kami melaporkan sebuah kasus seorang perempuan berusia 47 tahun dengan febrile neutropenia, infeksi lokal chemoport, dan kanker payudara on kemoterapi. Diagnosis ditegakkan berdasarkan anamnesis, gejala dan tanda klinis, serta pemeriksaan laboratorium absolute neutrophil count (ANC) 460 sel/mm3. Pasien diberikan terapi infus NaCl 0,9% 20 tetes/menit, ceftazidime injeksi 2 gr setiap 8 jam, dan filgastrim injeksi 300 mcg setiap 24 jam subkutan. Prognosis pasien ini secara ad vitam ialah dubia ad malam, ad functionam ialah dubia ad bonam, dan ad sanationam ialah dubia.Kata kunci: febrile neutropenia, pasca kemoterapi


Author(s):  
Arifa Moidady ◽  
Tenri Esa ◽  
Uleng Bahrun

The Absolute Neutrophil Count (ANC) is the absolute number of neutrophil derived from the multiplication of the relative number of leukocytes to the total neutrophil count. Neutrophils can be disturbed due to myelosupressive effects of chemotherapy. Fever is a common symptom in neutropenia patients due to chemotherapy. This fever is an emergency requiring rapid handling of Oncology and needs administration of appropriate antibiotics. Therefore, the data on the occurence of neutropenia and its related fever in patients whom accept chemotherapy after breast cancer it is important to be noted. This study is carried on to know the Absolute Neutrophil Count (ANC) in breast cancer patients with chemotherapy by analyzing them. The study was performed retrospectively by taking medical record data from January up to December 2012 in Dr. Wahidin Sudirohusodo Hospital Makassar. The absolute Neutrophil Count pre and afterchemotherapy analysis was done to determine neutropenia, as well as the febrile neutropenia and the correlation between ANC with patients age and stage of breast cancer. A total of 55 samples with the majority of patients (85.45%) were in the age group of 41–60 years old. The ANC after chemotherapy occurred in 50 patients were decreased (90.91%). There are five (5) patients (9.09%) with fever and two (2) persons (patients) (3.63%) suffered febrile neutropenia. The correlation analysis between decreased ANC with patient age and stage of breast cancer are p=0.054 and 0.070 respectively. Based on this study it can be concluded, that decreased ANC occurredin most patients after accepting chemotherapy but only few patients suffered febrile neutropenia. There was no significant correlation between the decreased ANC with patient age and stage of breast cancer


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