Faculty Opinions recommendation of The effects of isotretinoin therapy on serum homocysteine, folate and vitamin B12 levels in patients with acne: a meta-analysis and meta-regression.

Objectives: The study aimed to investigate the association of Crohn's disease (CD) with transcobalamin II (TCN2) polymorphisms and serum homocysteine, folate, and vitamin B12 levels. Methods:TCN2 (rs1801198, rs9606756) were genotyped by iMLDR in 389 CD patients and 746 controls. Furthermore, 102 CD patients and 153 controls were randomly selected for examination of serum homocysteine, folate, and vitamin B12 levels by enzymatic cycling assay and chemiluminescence immunoassay, respectively. Results: Mutant allele (G) and genotype (AG + GG) of (rs9606756) were higher in CD patients than in controls (both p < 0.05). So were they in ileocolonic CD patients and stricturing CD patients compared to controls (all p < 0.05). Mutant allele (G) and genotype (CG + GG) of (rs1801198) were more prevalent in stricturing CD patients than in controls (both p < 0.05). Compared to controls, average homocysteine level was enhanced in CD patients (p = 0.003), whereas average folate and vitamin B12 levels were reduced in CD patients (both p < 0.001). The prevalence of hyperhomocysteinemia, folate deficiency, and vitamin B12 deficiency was higher in CD patients than in controls (all p < 0.01). Both folate deficiency and vitamin B12 deficiency were independently related to risk of CD (both p < 0.01). Conclusion:TCN2 (rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B12 deficiency are correlated with CD.

Download Full-text

Serum Level of Homocysteine, Folate and Vitamin-B12 in Epileptic Patients Under Carbamazepine and Sodium Valproate Treatment: A Systematic Review and Meta-Analysis

Iranian Red Crescent Medical Journal ◽

10.5812/ircmj.9690 ◽

2013 ◽

Vol 15 (3) ◽

pp. 249-53 ◽

Cited By ~ 16

Author(s):

Fazel Gorjipour ◽

Yasin Asadi ◽

Nushin K. Osguei ◽

Marjan Effatkhah ◽

Ali Samadikuchaksaraei

Keyword(s):

Systematic Review ◽

Serum Level ◽

Vitamin B12 ◽

Sodium Valproate ◽

Meta Analysis ◽

Epileptic Patients ◽

Folate And Vitamin B12

Download Full-text

Clinical influence of maternal serum homocysteine, folate and vitamin B12 in the development of pre-eclampsia

Pteridines ◽

10.1515/pteridines-2019-0006 ◽

2019 ◽

Vol 30 (1) ◽

pp. 48-53 ◽

Cited By ~ 1

Author(s):

Hongyan Zhao ◽

Xu Zeng

Keyword(s):

Vitamin B12 ◽

Gestational Hypertension ◽

Severe Disease ◽

Serum Levels ◽

Maternal Serum ◽

Control Group ◽

Mild Disease ◽

Serum Homocysteine ◽

Folate And Vitamin B12 ◽

Serological Biomarkers

Abstract Background: The aim of this study was to investigate the correlation between maternal serum homocysteine (Hcy), folate, vitamin B12 (VitB12) and the development of pre-eclampsia (PE). Methods: Seventy-eight normal pregnant women (without hypertension and proteinuria during their pregnancy (control group)), 66 cases of gestational hypertension (GH group) and 82 cases of pre-eclampsia (PE group, with 56 cases of mild disease and 26 cases of severe disease) were include in this study. The maternal serum Hcy, folate and VitB12 level of the included cases were examined between 11 to 13 weeks gestation and compared between each group. Results: The serum levels of VitB12 were significantly different between the control, GH and PE groups (p<0.05). The serum levels of Hcy in the PE group were significantly higher than those of the control group (p<0.05). However, the serum levels of folate in the PE group were significantly lower than those of control group (p<0.05). Significant statistical differences in the maternal serum Hcy and folate were found between mild and severe PE patient groups (p<0.05). A significant correlation was found between maternal serum Hcy and VitB12 (r=-0.34, p=0.001). Conclusion: Hcy, folate and VitB12 may play an important role in the development of PE and could be potential serological biomarkers for early PE diagnosis.

Download Full-text