scholarly journals Clinical influence of maternal serum homocysteine, folate and vitamin B12 in the development of pre-eclampsia

Pteridines ◽  
2019 ◽  
Vol 30 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Hongyan Zhao ◽  
Xu Zeng
Keyword(s):  
Vitamin B12 ◽  
Gestational Hypertension ◽  
Severe Disease ◽  
Serum Levels ◽  
Maternal Serum ◽  
Control Group ◽  
Mild Disease ◽  
Serum Homocysteine ◽  
Folate And Vitamin B12 ◽  
Serological Biomarkers

Abstract Background: The aim of this study was to investigate the correlation between maternal serum homocysteine (Hcy), folate, vitamin B12 (VitB12) and the development of pre-eclampsia (PE). Methods: Seventy-eight normal pregnant women (without hypertension and proteinuria during their pregnancy (control group)), 66 cases of gestational hypertension (GH group) and 82 cases of pre-eclampsia (PE group, with 56 cases of mild disease and 26 cases of severe disease) were include in this study. The maternal serum Hcy, folate and VitB12 level of the included cases were examined between 11 to 13 weeks gestation and compared between each group. Results: The serum levels of VitB12 were significantly different between the control, GH and PE groups (p<0.05). The serum levels of Hcy in the PE group were significantly higher than those of the control group (p<0.05). However, the serum levels of folate in the PE group were significantly lower than those of control group (p<0.05). Significant statistical differences in the maternal serum Hcy and folate were found between mild and severe PE patient groups (p<0.05). A significant correlation was found between maternal serum Hcy and VitB12 (r=-0.34, p=0.001). Conclusion: Hcy, folate and VitB12 may play an important role in the development of PE and could be potential serological biomarkers for early PE diagnosis.

scholarly journals Evaluation of serum homocysteine and nitric oxide concentrations compared with other biochemical parameters in sheep naturally infected with Fasciola hepatica

2020 ◽  
Vol 71 (2) ◽  
pp. 2107
Author(s):  
V. DENIZHAN ◽  
S. KOZAT
Keyword(s):  
Nitric Oxide ◽  
Statistical Analysis ◽  
Vitamin B12 ◽  
Biochemical Parameters ◽  
Fasciola Hepatica ◽  
Control Group ◽  
Serum Homocysteine ◽  
Healthy Sheep ◽  
Animal Material ◽  
Folate And Vitamin B12

This study aims to determine the changes in serum homocysteine (Hcy) and nitric oxide (NO) concentrations in sheep naturally infected with F. hepatica. The animal material of the study consisted of a total of 50 sheep: 40 sheep with fascioliasis and 10 healthy sheep.The statistical analysis indicated that serum homocysteine concentrations, folate and vitamin B12 levels of the sheep infected with F. hepatica were higher than those of the control group (P<0.001 P<0.001 and P<0.05, respectively), whereas the nitric oxide levels of the sheep infected with F. hepatica were significantly lower than those of healthy sheep (P<0.001). In conclusion, it is thought that vitamin B12 and folate are not used sufficiently for the conversion of homocysteine to methionine in the remethylation cycle due to the damage in the liver tissue of sheep naturally infected with F. hepatica. This results in the increase of homocysteine which in turn inhibits the formation of nitric oxide.

Association between abnormal maternal serum levels of vitamin B12 and preeclampsia: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Farzaneh Mardali ◽  
Somaye Fatahi ◽  
Maryam Alinaghizadeh ◽  
Hamed Kord Varkaneh ◽  
Mohammad Hassan Sohouli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Data Extraction ◽  
Meta Analysis ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Folic Acid Supplementation ◽  
Maternal Serum ◽  
Study Selection

Abstract Context Some evidence has shown an association between maternal vitamin B12 levels and the development of preeclampsia in pregnant women, but the relationship between preeclampsia and vitamin B12 is not clear. Objective The aim of this systematic review was to compare serum vitamin B12 levels in women with preeclampsia with those in normotensive pregnant women. Data Sources The PubMed/MEDLINE, Scopus, and Web of Science databases were searched up to August 2019, along with the reference lists of included articles. Study Selection The literature was searched for observational studies that investigated vitamin B12 levels in women with preeclampsia. Data Extraction Data were extracted independently by 2 authors. Data were pooled using a random-effects model. Results Vitamin B12 levels in women with preeclampsia were significantly lower than those in healthy women (mean, −15.24 pg/mL; 95%CI, −27.52 to −2.954; P &lt; 0.015), but heterogeneity between studies was high (I2 = 97.8%; P = 0.0103). Subgroup analyses based on folic acid supplementation, homocysteine concentrations, and gestational age at the time of sampling for vitamin B12 assessment did not identify the sources of heterogeneity. Conclusions Women with preeclampsia had significantly lower vitamin B12 concentrations than normotensive pregnant women.

scholarly journals Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity

2020 ◽  
pp. bjophthalmol-2020-317953
Author(s):  
Miguel Ángel Zapata ◽  
Sandra Banderas García ◽  
Adrián Sánchez ◽  
Anna Falcó ◽  
Susana Otero-Romero ◽  
...  
Keyword(s):  
Respiratory Distress ◽  
Severe Disease ◽  
Control Group ◽  
Vascular Density ◽  
Mild Disease ◽  
Global Pandemic ◽  
Group 3 ◽  
Group 2 ◽  
Group Control Group ◽  
Group 1

BackgroundGlobal pandemic SARS-CoV-2 causes a prothrombotic state without fully elucidated effects. This study aims to analyse and quantify the possible retinal microvascular abnormalities.Materials and methodsCase–control study. Patients between 18 and 55 years old with PCR-confirmed SARS-CoV-2 infection within the last 3 months were included. Risk stratification: group 1—mild disease (asymptomatic/paucisymptomatic); group 2—moderate disease (required hospital admission with no acute respiratory distress) and group 3—severe disease (subjects who developed an acute respiratory distress were admitted in the intensive care unit and presented interleukin 6 values above 40 pg/mL). Age-matched volunteers with negative serology tests were enrolled to control group. A colour photograph, an optical coherence tomography (OCT) and an angiography using OCT centred on the fovea were performed.ResultsControl group included 27 subjects: group 1 included 24 patients, group 2 consisted of 24 patients and 21 participants were recruited for group 3. There were no funduscopic lesions, neither in the colour images nor in the structural OCT. Fovea-centred vascular density (VD) was reduced in group 2 and group 3 compared with group 1 and control group (control group vs group 2; 16.92 vs 13.37; p=0.009) (control group vs group 3; 16.92 vs .13.63; p=0.026) (group 1 vs group 2; 17.16 vs 13.37; p=0.006) (group 1 vs group 3; 17.16 vs 13.63 p=0.017).ConclusionPatients with moderate and severe SARS-CoV-2 pneumonia had decreased central retinal VD as compared with that of asymptomatic/paucisymptomatic cases or control subjects.

scholarly journals Fingerprints: A simple method for Screening Hemophilic Patients

2015 ◽  
Vol 40 (2) ◽  
pp. 85-88
Author(s):  
M Jamalian ◽  
M Mesri ◽  
HRK Vishteh ◽  
H Solhi ◽  
R Salehpour
Keyword(s):  
Severe Disease ◽  
Healthy People ◽  
Control Group ◽  
Case Group ◽  
Factor Level ◽  
Simple Method ◽  
Mild Disease ◽  
Normal People ◽  
Significant Difference ◽  
New Occurrences

Background: The present study aims to compare hemophilic patients’ fingerprint types with the normal people to help diagnose the disease, particularly new occurrences of the disease. Method: This casecontrol study was conducted in 2012. Sixty two patients with hemophilia type A and 62 normal healthy people were selected. The type of fingerprint was determined by a forensic specialist who was kept unaware of the participants’ group. Using advanced Henry method, the main types of fingerprints were classified as arch, loop, whorl, as well as other types. Results: In the control group, loop type (65%) and in the case group the whorl type (34%) were the most frequent fingerprint type (p<0.001) and there was a significant difference of fingerprint in each finger between two groups. In addition, the average number of whorl type in the patients with mild disease was significantly higher and the average number of arch and other types of fingerprints was significantly lower than patients with moderate or severe disease. Conclusion: The findings of the present study indicated that not only are the fingerprints of normal and hemophilic people different, but also a difference was observed between hemophilic patients with the mild factor level and patients with moderate or severe one.Bangladesh Med Res Counc Bull 2014; 40 (2): 85-88

scholarly journals Correlation between secondary thrombosis in epileptic patients and serum levels of folate and vitamin B12

2016 ◽  
Vol 5 (4) ◽  
pp. 417-420 ◽  
Author(s):  
Hao Zhou ◽  
Hong-Li Huang ◽  
Nuan Wang ◽  
Xiao-Hu Pang
Keyword(s):  
Vitamin B12 ◽  
Serum Levels ◽  
Epileptic Patients ◽  
Folate And Vitamin B12

scholarly journals Determinants of plasma homocysteine in coal miners.

2013 ◽  
Vol 60 (3) ◽  
Author(s):  
A Görkem Mungan ◽  
Murat Can ◽  
Sibel Kiran ◽  
Serefden Açikgöz ◽  
Berrak Güven
Keyword(s):  
Vitamin B12 ◽  
Cystatin C ◽  
Kinetic Method ◽  
Serum Levels ◽  
Health Problems ◽  
High Serum ◽  
Serum Folate ◽  
Control Group ◽  
Coal Miners ◽  
Group Control Group

Several studies suggest that coal miners are under risk of severe health problems such as cardiovascular, pulmonary, neurological, renal, hematological and musculoskeletal disorders. However, there are limited data on biochemical changes in underground workers. In our study we aimed to evaluate the association between serum homocysteine (Hcy), vitamin B12, cystatin C and folate levels in the blood of underground coal miners. Eighty one coal miners who work as underground or surface workers were recruited into our study. The study population was divided into two groups: the surface worker group (control group, n=33) and the underground worker group (n=48). The folate, vitamin B12, Hcy, cystatin C levels and body mass indexes (BMI) of both groups were measured and compared. Serum folate, Hcy and vitamin B12 levels were measured with a competitive chemiluminescence immunassay. Serum levels of cystatin C were determined by the latex particle-enhanced turbidimetric method using a cystatin C kit. Urea values were measured with a kinetic method on an automated analyzer. There were no statistically significant differences between the underground workers and surface workers in the urea, cystatin C and vitamin B12 levels. High serum Hcy levels and low folate levels were found in underground workers compared with those in surface workers. The correlation between Hcy and folate levels was also statistically significant. Similarly, there was also a significant correlation between Hcy and vitamin B12, and between Hcy and cystatin C levels. Elevated Hcy levels may be associated with underground working but further research is necessary to understand the relation between elevated Hcy and increased prevalence of health problems in coal miners.

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