Faculty Opinions recommendation of Effect of folic acid and zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: A randomized clinical trial.

2020 ◽  
Author(s):  
Audrey Gaskins
Keyword(s):  
Clinical Trial ◽  
Folic Acid ◽  
Randomized Clinical Trial ◽  
Live Birth ◽  
Zinc Supplementation ◽  
Semen Quality ◽  
Infertility Treatment

scholarly journals Effects of folic acid and zinc supplementation in men on semen quality and live birth among couples undergoing infertility treatment: findings from the fazst randomized trial

2019 ◽  
Vol 112 (3) ◽  
pp. e2
Author(s):  
Enrique F. Schisterman ◽  
Lindsey A. Sjaarda ◽  
Traci Clemons ◽  
Douglas T. Carrell ◽  
Neil J. Perkins ◽  
...  
Keyword(s):  
Folic Acid ◽  
Randomized Trial ◽  
Live Birth ◽  
Zinc Supplementation ◽  
Semen Quality ◽  
Infertility Treatment

scholarly journals Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment

JAMA ◽  
2020 ◽  
Vol 323 (1) ◽  
pp. 35 ◽  
Author(s):  
Enrique F. Schisterman ◽  
Lindsey A. Sjaarda ◽  
Traci Clemons ◽  
Douglas T. Carrell ◽  
Neil J. Perkins ◽  
...  
Keyword(s):  
Folic Acid ◽  
Live Birth ◽  
Zinc Supplementation ◽  
Semen Quality ◽  
Infertility Treatment

scholarly journals Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial

2017 ◽  
Vol 103 (3) ◽  
pp. 870-881 ◽  
Author(s):  
Martin Blomberg Jensen ◽  
Jacob Gerner Lawaetz ◽  
Jørgen Holm Petersen ◽  
Anders Juul ◽  
Niels Jørgensen
Keyword(s):  
Clinical Trial ◽  
Vitamin D ◽  
Randomized Clinical Trial ◽  
Live Birth ◽  
Birth Rate ◽  
Semen Quality ◽  
Live Birth Rate ◽  
Vitamin D Supplementation ◽  
Reproductive Hormones

scholarly journals A Randomized Trial to Evaluate the Effects of Folic Acid and Zinc Supplementation on Male Fertility and Livebirth: Design and Baseline Characteristics

2019 ◽  
Vol 189 (1) ◽  
pp. 8-26 ◽  
Author(s):  
Enrique F Schisterman ◽  
Traci Clemons ◽  
C Matthew Peterson ◽  
Erica Johnstone ◽  
Ahmad O Hammoud ◽  
...  
Keyword(s):  
Folic Acid ◽  
Zinc Supplementation ◽  
Semen Quality ◽  
Controlled Trial ◽  
Infertility Treatment ◽  
Lessons Learned ◽  
Double Blind ◽  
Female Partners ◽  
Participant Characteristics

Abstract The Folic Acid and Zinc Supplementation Trial (FAZST) was a multicenter, double-blind, block-randomized, placebo-controlled trial to determine whether folic acid and zinc supplementation in men improves semen quality and increases livebirth rate among couples seeking infertility treatment (2013–2017). Eligible men were aged 18 years or older with female partners aged 18–45 years, seeking infertility treatment. Men were randomized (1:1) to 5 mg folic acid and 30 mg elemental zinc daily or matching placebo for 6 months. Randomization was stratified by site and intended infertility treatment (in vitro fertilization (IVF), non-IVF/study site, and non-IVF/outside clinic). Follow-up of men continued for 6 months, and female partners were passively followed for a minimum of 9 months. Women who conceived were followed throughout pregnancy. Overall, 2,370 men were randomized during 2013–2017 (1,185 folic acid and zinc, 1,185 placebo); they had a mean age of 33 years and body mass index (weight (kg)/height (m)2) of 29.8. Most participants were white (82%), well educated (83% with some college), and employed (72%). Participant characteristics were balanced across intervention arms. Study visits were completed by 89%, 77%, and 75% of men at months 2, 4, and 6, respectively. Here we describe the study design, recruitment, data collection, lessons learned, and baseline participant characteristics.

Intramuscular Progesterone Optimizes Live Birth From Programmed Frozen Embryo Transfer: A Randomized Clinical Trial

2021 ◽  
Vol 76 (12) ◽  
pp. 744-745
Author(s):  
Kate Devine ◽  
Kevin S. Richter ◽  
Samad Jahandideh ◽  
Eric A. Widra ◽  
Jeffrey L. McKeeby
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Embryo Transfer ◽  
Live Birth ◽  
Frozen Embryo Transfer

scholarly journals PERMA model vs. integrative-behavioral couple therapy for fertility problems: A randomized clinical trial protocol

2021 ◽  
Author(s):  
Mahsa Sadeghi ◽  
Tahmineh Farajkhoda ◽  
Mahdi Khanabadi ◽  
Maryam Eftekhar
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Couple Therapy ◽  
Primary Outcome ◽  
Cognitive Intervention ◽  
Infertility Treatment ◽  
Problem Solving Skills ◽  
Face To Face ◽  
Integrative Behavioral Couple Therapy ◽  
Fertility Problems

Background: Psychological interventions may reduce fertility problems. Positive emotion, engagement, meaning, positive relationship and accomplishment (PERMA) is a cognitive intervention and integrative-behavioral couple therapy (IBCT) is a behavioral intervention. Appropriate mental interventions are important in infertility treatment. Objective: To investigate the effect of the PERMA model vs. IBCT in reducing the fertility problems of couples. Materials and Methods: The content of the interventions was developed and adjusted based on a literature review and the opinions of experts. In this three-arm parallel randomized clinical trial, 42 couples undergoing infertility treatment will be allocated randomly into three groups (n = 14 couples/each). Group 1 will receive the PERMA intervention, group 2 will receive the IBCT intervention, and group 3 as the control group will receive an infertility treatment training program intervention. The primary outcome will be the fertility problems, which will be measured by completing a fertility problem inventory at baseline, as well as in the 5th and 9th wk as a follow-up. Another primary outcome, satisfaction with the intervention, will also be assessed in the 5th and 9th wk. The secondry outcome will be a positive pregnancy test at wk 12. The interventions will be conducted through a combination of face-to-face and online via WhatsApp. Conclusion: This study will assess social, sexual, and parenthood concerns. A combination of online and face-to-face interventions will be appropriate given the COVID-19 pandemic. Couple’s counseling may provide better counseling outcomes for fertility problems in comparison with group counseling. This study will try to optimize resilience during infertility treatment through learning better relationship and problem-solving skills, and may have an indirect impact on pregnancy rate, burden of infertility, and costs of treatment due to increased effectiveness. Key words: Online, Face-to-face, Infertility, Integrative-behavioral couple therapy, PERMA model, RCT, Positive psychology, Protocol study, COVID-19.

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