Faculty Opinions recommendation of Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia.

Author(s):  
Bruce Bistrian
2010 ◽  
Vol 93 (2) ◽  
pp. 243-252 ◽  
Author(s):  
Ann C Skulas-Ray ◽  
Penny M Kris-Etherton ◽  
William S Harris ◽  
John P Vanden Heuvel ◽  
Paul R Wagner ◽  
...  

2018 ◽  
Vol 46 (12) ◽  
pp. 5074-5082 ◽  
Author(s):  
Thomas Kander ◽  
Erik Lindblom ◽  
Ulf Schött

Objective This study aimed to evaluate the dose-response effects of supplemental omega-3 fatty acids on platelet function in healthy volunteers. Methods Twelve healthy volunteers ingested a normal supplemental dose of 1260 mg omega-3 fatty acids daily for 5 days, followed by a high dose of 2520 mg daily for another 5 days. Multiple electrode aggregometry (MEA) with four different agonists was used to measure platelet aggregation before and after the normal- and high-dose regimes. In vitro spiking using physiological doses of omega-3 fatty acids was also performed to determine whether MEA is capable of detecting a platelet-inhibiting effect due to omega-3 fatty acids. Results There were no differences in platelet aggregation measured by the MEA assay in healthy volunteers after intake of either the normal or high dose of omega-3 fatty acids. In the in vitro experiment, a platelet-inhibiting effect of omega-3 fatty acids was shown by an arachidonic acid agonist in MEA . Conclusions Supplemental omega-3 fatty acids do not evoke their positive health effects through inhibition of platelet aggregation measurable with MEA.


2014 ◽  
Vol 15 (4) ◽  
pp. 305-314 ◽  
Author(s):  
Aleksandra Żebrowska ◽  
Katarzyna Mizia-Stec ◽  
Magda Mizia ◽  
Zbigniew Gąsior ◽  
Stanisław Poprzęcki

2012 ◽  
Vol 221 (2) ◽  
pp. 536-543 ◽  
Author(s):  
Qianqian Wang ◽  
Xiaohua Liang ◽  
Laiyuan Wang ◽  
Xiangfeng Lu ◽  
Jianfeng Huang ◽  
...  

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