scholarly journals INFLUENCE OF SYSTEMIC INFLAMMATORY REACTIONS ON THE COURSE OF PANCREOECROSIS

2019 ◽  
Vol 42 (3) ◽  
pp. 64-68
Author(s):  
Boyko V. V. ◽  
Lichman V. N. ◽  
Shevchenko A. N. ◽  
Merkulov A. A. ◽  
Polikov H. O. ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Inflammatory Response ◽  
Inflammatory Reaction ◽  
Pancreatic Necrosis ◽  
Multiorgan Failure ◽  
Necrotizing Pancreatitis ◽  
Multiple Organ ◽  
Systemic Inflammatory Response ◽  
Systemic Inflammatory Reaction ◽  
Acute Necrotizing

Introduction. Acute pancreatitis is a common pathology in abdominal surgery, so the prevalence reaches 238 cases per million populations. It should be noted that pancreatic necrosis develops in 25% of patients with acute pancreatitis, and mortality can reach up to 20%. Purpose of the study. The investigate effect on the pancreatic necrosis course of the systemic inflammatory response. Materials and methods. We examined 96 patients aged from 19 to 78 years. During the course of the disease, a systemic inflammatory response developed in 79% of patients with acute necrotizing pancreatitis. Results. It was found that the lethal cases of acute necrotic pancreatitis occurred only with the development of multiple organ failure with a score of 6 or more on the SOFA scale. The correlation coefficients between the signs, affecting the risk of developing severe multiorgan failure, were calculated. It was proved that in case of a pronounced systemic inflammatory reaction, a patient produces a large amount of free fluid in the abdominal cavity, and is a risk of an early fatal outcome. It should be noted that in the presence of obesity there was a tendency to the risk of developing severe multiorgan failure. Conclusion. In acute necrotizing pancreatitis, the risk of severe multiorgan failure and death is only in patients with a systemic inflammatory reaction (especially in the presence of obesity and the elderly patient), and the degree of risk reliably depends on the severity of signs of an inflammatory response. Keywords: acute pancreatitis, pancreatic necrosis, systemic inflammatory response syndrome, multiple organ failure, septic complications.

scholarly journals Familial Chylomicronemia Syndrome-Induced Acute Necrotizing Pancreatitis during Pregnancy

2021 ◽  
Vol 43 (03) ◽  
pp. 220-224
Author(s):  
Julia Cristina Coronado Arroyo ◽  
Marcio José Concepción Zavaleta ◽  
Eilhart Jorge García Villasante ◽  
Mikaela Kcomt Lam ◽  
Luis Alberto Concepción Urteaga ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Clinical Course ◽  
Necrotizing Pancreatitis ◽  
Rare Condition ◽  
Severe Hypertriglyceridemia ◽  
Fetal Complications ◽  
Acute Necrotizing ◽  
History Of ◽  
Important Objective

AbstractAcute pancreatitis is a rare condition in pregnancy, associated with a high mortality rate. Hypertriglyceridemia represents its second most common cause. We present the case of a 38-year-old woman in the 24th week of gestation with a history of hypertriglyceridemia and recurrent episodes of pancreatitis. She was admitted to our hospital with acute pancreatitis due to severe hypertriglyceridemia. She was stabilized and treated with fibrates. Despite her favorable clinical course, she developed a second episode of acute pancreatitis complicated by multi-organ dysfunction and pancreatic necrosis, requiring a necrosectomy. The pregnancy was ended by cesarean section, after which three plasmapheresis sessions were performed. She is currently asymptomatic with stable triglyceride levels. Acute pancreatitis due to hypertriglyceridemia represents a diagnostic and therapeutic challenge in pregnant women, associated with serious maternal and fetal complications. When primary hypertriglyceridemia is suspected, such as familial chylomicronemia syndrome, the most important objective is preventing the onset of pancreatitis.

scholarly journals Staged treatment of acute necrotizing pancreatitis given the configuration of pancreatic necrosis (case report)

2021 ◽  
Vol 26 (2) ◽  
pp. 61-67
Author(s):  
А. V. Shefer ◽  
E. N. Belykh
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Clinical Observation ◽  
Necrotizing Pancreatitis ◽  
Fluid Collection ◽  
Acute Necrotizing ◽  
Data Configuration ◽  
Ct Data ◽  
High Level ◽  
Staged Treatment

A clinical observation of a successful staged treatment of a patient with severe acute pancreatitis based on early diagnosis of damage to the pancreatic duct according to CT data (configuration of pancreatic necrosis) and high level of amylase in the fluid collection is presented.

scholarly journals AKI Associated with Acute Pancreatitis

2019 ◽  
Vol 14 (7) ◽  
pp. 1106-1115 ◽  
Author(s):  
Tareq I. Nassar ◽  
Wajeh Y. Qunibi
Keyword(s):  
Acute Pancreatitis ◽  
Severe Acute Pancreatitis ◽  
Multiorgan Failure ◽  
Necrotizing Pancreatitis ◽  
Volume Depletion ◽  
Humoral Factors ◽  
Systemic Complications ◽  
Kidney Replacement Therapy ◽  
Acute Necrotizing ◽  
Hospital Deaths

Acute pancreatitis is a common disorder of the pancreas. It is the most frequent gastrointestinal cause for hospitalization and one of the leading causes of in-hospital deaths. Its severity ranges from mild self-limited disease to severe acute necrotizing pancreatitis characterized by systemic complications and multiorgan failure. Severe acute pancreatitis develops in about 20% of patients with acute pancreatitis and may be associated with multiorgan failure (respiratory, cardiovascular, and kidney). AKI is a frequent complication of severe acute pancreatitis and develops late in the course of the disease, usually after the failure of other organs. It carries a very poor prognosis, particularly if kidney replacement therapy is required, with mortality rates exceeding 75%. The exact pathophysiology of AKI in acute pancreatitis remains unclear but appears to result from initial volume depletion followed by complex vascular and humoral factors. Here, we provide an overview of the epidemiology, pathogenesis, causes, and management of AKI in patients with severe acute pancreatitis.

Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome

2003 ◽  
Vol 31 (4) ◽  
pp. 1048-1052 ◽  
Author(s):  
Takeshi Motoyama ◽  
Kazufumi Okamoto ◽  
Ichirou Kukita ◽  
Masamichi Hamaguchi ◽  
Yoshihiro Kinoshita ◽  
...  
Keyword(s):  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Oxidant Stress ◽  
Multiple Organ ◽  
Systemic Inflammatory Response

scholarly journals Systemic inflammatory response syndrome and multiple-organ damage / dysfunction in complicated canine babesiosis

2001 ◽  
Vol 72 (3) ◽  
Author(s):  
C. Welzl ◽  
A.L. Leisewitz ◽  
L.S. Jacobson ◽  
T. Vaughan-Scott ◽  
E. Myburgh
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Renal Involvement ◽  
Organ Damage ◽  
Multiple Organ ◽  
Systemic Inflammatory Response ◽  
The Body ◽  
Increased Risk

This study was designed to document the systemic inflammatory response syndrome (SIRS) and multiple-organ dysfunction syndrome (MODS) in dogs with complicated babesiosis, and to assess their impact on outcome. Ninety-one cases were evaluated retro-spectively for SIRS and 56 for MODS. The liver, kidneys, lungs, central nervous system and musculature were assessed. Eighty-seven percent of cases were SIRS-positive. Fifty-two percent of the cases assessed for organ damage had single-organ damage and 48 % had MODS. Outcome was not significantly affected by either SIRS or MODS, but involvement of specific organs had a profound effect. Central nervous system involvement resulted in a 57 times greater chance of death and renal involvement in a 5-fold increased risk compared to all other complications. Lung involvement could not be statistically evaluated owing to co-linearity with other organs, but was associated with high mortality. Liver and muscle damage were common, but did not significantly affect outcome. There are manysimilarities between the observations in this study and previous human and animal studies in related fields, lending additional support to the body of evidence for shared underlying pathophysiological mechanisms in systemic inflammatory states.

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