SOME QUESTIONS ABOUT THE STATE OF THE EYE SURFACE IN PATIENTS BEFORE CATARACT SURGERY

Introduction. Ocular surface status is a main risk factor for the development of postoperative complications and lead to the decrease of life quality. Purpose of the study.The condition of the surface of the eye in patients before cataract surgery was study. Material and methods. 320 patients preoperative the cataract surgery were investigated, among them 172 patients were female, 148 – were male. Patients with any previous ocular surgery or concomitant ocular diseases were excluded. The structure of common non-ocular comorbidities, subjective signs of ocular surface damage (redness, foreign body sensation, dryness, burning) and objective symptoms (tear break up time, cornea fluorescein staining) were carried out. Patients with asymptomatic forms of cornea staining were identified. Results. It was found that 100 patients (31,2%) had subjective signs (specific complains) of ocular surface damage and 135 patients (35,5%) had positive corneal staining. Specific complains and obvious ocular surface damage were revealed in 17,7% and latent ocular surface damage – in 16,9% of patients. Thus 49% of patients had asymptomatic form of ocular surface damage. In the group of patients with diabetes mellitus healthy ocular surface was observed only in 35,6% cases, asymptomatic form of ocular surface damage consisted 72,9% and obvious damage – 16,9% among all patients. Conclusion. Ocular surface dysfunction is common among patients before cataract surgery, especially in diabetes mellitus. Clinicians should be aware of this high prevalence and consider ocular surface screening before cataract surgery. Keywords. Ocular surface damage, cataract, tear break up time, fluorescein corneal staining.

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Reduction of Ocular Surface Damage and Bacterial Survival Using 0.05% Povidone-Iodine Ocular Surface Irrigation before Cataract Surgery

Ophthalmic Research ◽

10.1159/000501373 ◽

2019 ◽

Vol 62 (3) ◽

pp. 166-172 ◽

Cited By ~ 2

Author(s):

Fang Fan ◽

Zhihua Zhao ◽

Xiaobin Zhao ◽

Qingmin Ma ◽

Kejun Li ◽

...

Keyword(s):

Cataract Surgery ◽

Ocular Surface ◽

Povidone Iodine ◽

Surface Damage ◽

Bacterial Survival ◽

Surface Irrigation

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Posterior capsule opacification after cataract surgery in patients with diabetes mellitus

Journal of Cataract & Refractive Surgery ◽

10.1016/j.jcrs.2006.01.100 ◽

2006 ◽

Vol 32 (7) ◽

pp. 1184-1187 ◽

Cited By ~ 39

Author(s):

Yoko Ebihara ◽

Satoshi Kato ◽

Tetsuro Oshika ◽

Mayumi Yoshizaki ◽

Gentaro Sugita

Keyword(s):

Diabetes Mellitus ◽

Cataract Surgery ◽

Posterior Capsule Opacification ◽

Posterior Capsule ◽

Patients With Diabetes

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Morphological and Functional Assessment of Meibomian Glands in Keratoconus

10.21203/rs.3.rs-932693/v1 ◽

2021 ◽

Author(s):

Ömür Ö Uçakhan ◽

Gökçen Özcan

Keyword(s):

Ocular Surface ◽

Tear Film ◽

Early Screening ◽

Ocular Surface Disease Index ◽

Non Invasive ◽

The Mean ◽

Meibomian Glands ◽

Break Up ◽

And Function ◽

Corneal Staining

Abstract Purpose: To evaluate the morphology and function of the meibomian glands (MG) in keratoconus patients.Methods: One hundred eyes of 100 keratoconus patients and 100 eyes of 100 age-matched healthy subjects were included into this study. Ocular Surface Disease Index (OSDI) scores, non-invasive break up time (NIBUT), meibography findings, fluorescein staining of the ocular surface, tear film break-up time (TBUT), and Schirmer I test were recorded in all patient eyes and were compared with controls.Results: The mean TBUT and NIBUT were significantly lower, corneal staining and OSDI scores were statistically higher in the keratoconus group (p<0.05). The mean meiboscore, partial gland, gland dropout and gland thickening scores of the upper and lower eyelids were significantly higher in keratoconus patients compared to controls (p<0.05). The NIBUT measurements significantly correlated with MG loss in both upper and lower eyelids (p<0.05). The severity of keratoconus seemed to correlate with meiboscore, partial gland, gland thickening scores in both upper and lower eyelids. Conclusion: Our data suggest that corneal ectasia in keratoconus is associated with alterations in ocular surface, tear film function and MG morphology. Early screening and treatment of MG dysfunction may improve ocular surface quality and allow better disease management in keratoconus patients.

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Outcome of cataract surgery in diabetic patients

Medicinski pregled ◽

10.2298/mpns1808217c ◽

2018 ◽

Vol 71 (7-8) ◽

pp. 217-221

Author(s):

Vladimir Canadanovic ◽

Nikola Babic ◽

Sofija Davidovic ◽

Aleksandar Miljkovic ◽

Stefan Brunet ◽

...

Keyword(s):

Diabetes Mellitus ◽

Visual Acuity ◽

Cataract Surgery ◽

Intraoperative Complications ◽

Glycosylated Hemoglobin ◽

Diabetic Patients ◽

Ophthalmological Examination ◽

Time Of Surgery ◽

Patients With Diabetes ◽

Novi Sad

Introduction. The association between diabetes and cataract formation has been shown in many clinical studies. Development of cataract occurs more frequently and at an earlier age in diabetic patients. Due to the increasing prevalence of diabetes worldwide, the incidence of diabetic cataracts steadily rises. While the overall outcomes of cataract surgery are excellent, patients with diabetes may have poorer vision outcomes than those without diabetes. The objective of this study was to evaluate the visual outcomes (visual acuity and visual function), intraoperative and postoperative complications of cataract surgery, and to assess the final surgical outcomes. Material and Methods. The prospective study included 128 patients (133 eyes) with cataract and diagnosis of diabetes mellitus type 2 at least 5 years prior to cataract surgery, operated at the Eye Clinic, Clinical Center of Vojvodina, Novi Sad. A full medical history included patients? age, the time since the diagnosis of diabetes, current management of diabetes, blood pressure and assessment of glycemic control using glycosylated hemoglobin. All patients underwent complete ophthalmological examination before cataract surgery, and were re-examined 7 days, one and six months after the surgery. Results. The mean age of patients at the time of surgery was 63.5 years (SD ? 6.5, range 57 - 70 years) with mean duration of diabetes 8.5 years. The glycosylated haemoglobin level in the group treated with insulin was 6.8 vs. 8.2 in patients on oral medications (p < 0.05). Diabetes mellitus was accompanied by other systemic diseases in 81 patients (63.28%), whereas 45 of 133 operated eyes (33.83%) had other ocular diseases. Intraoperative complications occurred in 20 of 133 operated eyes (15%): posterior capsular rupture with vitreous loss, intraoperative miosis, iris hemorrhage and suprachoroidal hemorrhage. Conclusion. Cataract surgery with intraocular lens implantation is an effective and safe surgical procedure in diabetic patients, and sight threatening complications are rare. Our study confirmed that visual acuity after surgery in diabetic patients depends on the severity of diabetic retinopathy at the time of surgery.

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Diabetic retinopathy progression in the patients with diabetes mellitus of II type after cataract surgery

Oftalmologicheskii Zhurnal ◽

10.31288/oftalmolzh200942226 ◽

2009 ◽

Vol 4 (20) ◽

pp. 22-26

Author(s):

T. Oleynik ◽

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Cataract Surgery ◽

Patients With Diabetes

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Corneal Microstructural Changes in Nerve Fiber, Endothelial and Epithelial Density After Cataract Surgery in Patients With Diabetes Mellitus

Cornea ◽

10.1097/ico.0000000000000320 ◽

2015 ◽

Vol 34 (2) ◽

pp. 177-181 ◽

Cited By ~ 24

Author(s):

Stuti L. Misra ◽

Yi Wei Goh ◽

Dipika V. Patel ◽

Andrew F. Riley ◽

Charles N.J. McGhee

Keyword(s):

Diabetes Mellitus ◽

Cataract Surgery ◽

Nerve Fiber ◽

Microstructural Changes ◽

Patients With Diabetes

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Discrepancies in Persistent Dry Eye Signs and Symptoms in Bilateral Pseudophakic Patients

Journal of Clinical Medicine ◽

10.3390/jcm8020211 ◽

2019 ◽

Vol 8 (2) ◽

pp. 211 ◽

Cited By ~ 3

Author(s):

Akiko Hanyuda ◽

Masahiko Ayaki ◽

Kazuo Tsubota ◽

Kazuno Negishi

Keyword(s):

Cataract Surgery ◽

Dry Eye ◽

Ocular Surface ◽

Bright Light ◽

Signs And Symptoms ◽

Clinical Tests ◽

Blurred Vision ◽

Body Sensation ◽

Ocular Fatigue ◽

Fatigue Sensitivity

Despite the increased awareness of early prophylaxis and treatment for dry eye disease (DED) during the first few weeks after cataract surgery, the chronic effect of cataract surgery on the risk of ocular surface abnormalities has not been fully explored. This study was to assess the prevalence of DE subjective symptoms and clinical tests according to the cataract surgery. A total of 172 patients who underwent bilateral cataract surgeries at least 5 months before the recruitment date and 1225 controls with no cataracts were evaluated for their subjective DE symptoms (dry sensation, foreign-body sensation, ocular pain, ocular fatigue, sensitivity to bright light, and blurred vision) and ophthalmic parameters (tear break-up time, keratoconjunctival staining scores, and maximum blinking interval). The presence of subjective DE symptoms was generally inversely associated with cataract surgeries, whereas abnormal clinical tests were more pronounced among postsurgical cataract patients than among controls. Pseudophakic patients showed a 57% increased prevalence of severe keratoconjunctivitis, compared to controls (P = 0.02). In contrast, among subjective DE symptoms, significantly lower odds of sensitivity to bright light were detected among cases than controls; the multivariable-adjusted odds ratio (95% confidence interval) comparing pseudophakic patients with noncataract patients was 0.56 (0.34–0.92) (P = 0.02). In conclusion, persistent tear instability and corneal epitheliopathy were found even at several months or more after cataract surgery. This study demonstrates the importance of evaluating ocular surface conditions in pseudophakic patients, even if they lack DE symptoms.

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Corneal Microstructural Changes in Nerve Fiber, Endothelial and Epithelial Density After Cataract Surgery in Patients With Diabetes Mellitus

Cornea ◽

10.1097/ico.0000000000000672 ◽

2015 ◽

Vol 34 (12) ◽

pp. e40 ◽

Cited By ~ 1

Keyword(s):

Diabetes Mellitus ◽

Cataract Surgery ◽

Nerve Fiber ◽

Microstructural Changes ◽

Patients With Diabetes

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Large capsulorhexis with implantation of a 7.0 mm optic intraocular lens during cataract surgery in patients with diabetes mellitus

Journal of Cataract & Refractive Surgery ◽

10.1016/j.jcrs.2014.02.039 ◽

2014 ◽

Vol 40 (11) ◽

pp. 1850-1856 ◽

Cited By ~ 2

Author(s):

Yoshihiro Takamura ◽

Takeshi Tomomatsu ◽

Satoshi Yokota ◽

Takehiro Matsumura ◽

Yuji Takihara ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cataract Surgery ◽

Intraocular Lens ◽

Patients With Diabetes

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Conjunctival Microbiota in Patients With Type 2 Diabetes Mellitus and Influences of Perioperative Use of Topical Levofloxacin in Ocular Surgery

Frontiers in Medicine ◽

10.3389/fmed.2021.605639 ◽

2021 ◽

Vol 8 ◽

Author(s):

Xiangjia Zhu ◽

Ling Wei ◽

Xianfang Rong ◽

Yinglei Zhang ◽

Qian Zhang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Ocular Surface ◽

Diabetic Patients ◽

Ocular Surgery ◽

Α Diversity ◽

Rdna Sequencing

Background: Patients with type 2 diabetes mellitus (T2DM) are prone to ocular surface infections. We therefore characterized the conjunctival microbiome of T2DM patients and the influence of topical levofloxacin to investigate whether a dysbiosis is associated with this phenomenon.Methods: Conjunctival microbiome of 79 T2DM patients and 113 non-diabetic controls was profiled using the 16S rDNA sequencing approach. Furthermore, 21 T2DM and 14 non-diabetic patients who underwent cataract surgeries were followed up perioperatively and the influence of pre- and post-operative levofloxacin on the conjunctival microbiome was further investigated prospectively and compared longitudinally.Results: The α-diversity of the conjunctival microbiota was significantly higher in T2DM patients than in controls (P < 0.05). Significant differences in both composition and function of the conjunctival microbiome were identified on the ocular surface of T2DM patients as compared to non-diabetic controls. Particularly, phylum Bacteroidetes and Fusobacteria, genus Pseudomonas, Haemophilus, and Empedobacter were enriched, while genus Streptococcus was reduced on the T2DM ocular surface. Microbial genes functioning of bacterial chemotaxis was elevated in the conjunctival microbiome of T2DM patients. Furthermore, compared to the initial status, several genera including Staphylococcus were more abundant in the conjunctival microbiome of T2DM patients after 3-days use of preoperative levofloxacin topically, while no genus was more abundant in the non-diabetic follow-up group. No difference was observed between initial status and 7 days after ceasing all postoperative medications in both diabetic and non-diabetic follow-up groups.Conclusions: The conjunctival microbiome of T2DM patients was more complex and may respond differently to topical antibiotics.

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