Doping in sport, with its connotations of unethical behaviour and harm to health, has existed since antiquity. In contemporary times, an acceleration of doping practices resulted in the eventual development of a robust legal and scientific framework now entrenched in the World Anti-Doping Code. Young athletes are not immune to the myriad pressures to excel that exist in high-level sport. Many of these athletes are subject to Anti-Doping regulations and therefore they (and their physicians) must be familiar with Anti-Doping procedures and processes, including the Prohibited List and Therapeutic Use Exemptions. Advances in analytical and non-analytical techniques and strategies have increased detection and accountability. As part of the athletic team, physicians are in a unique position to recognize vulnerabilities and signs of doping behaviour. This must enable them to positively impact the course of a young athlete’s trajectory in life.