scholarly journals Manajemen Intervensi HOT FLUSH dengan Menggunakan BodyWipe

2021 ◽  
Vol 11 (1) ◽  
pp. 23-29
Author(s):  
Bina Aquari
Keyword(s):  
Hot Flush

Gejala paling umum yang dialami wanita menopause, yaitu hot flush. Hot Flush adalah perasaan panas yang muncul mulai dari bagian atas tubuh dan menyebar ke wajah. Intervensi yang dilakukan untuk mendinginkan hot flush dengan menggunakan body wipe. Body Wipe adalah alat penyeka tubuh yang memberikan kesegaran. Penelitian ini bertujuan untuk mengetahui pengaruh body wipe sebagai manajemen intervensi hot flush pada wanita menopause di Klinik/BP Anisa. Penelitian ini merupakan eksperimen dengan menggunakan rancangan eksperimen semu. Data diperoleh dengan kuisioner untuk karakteristik umur, pendidikan dan pekerjaan sedangkan observasi untuk suhu sebelum dan sesudah diberi manajemen intervensi body wipe. Sampel penelitian ini adalah wanita menopause berjumlah 12 orang yang berkunjung untuk berobat di Klinik/BP Anisa. Metode analisis data menggunakan uji statistik wilcoxon. Analisis Univariat menunjukan suhu tinggi pada suhu sebelum diberi manajemen intervensi body wipe (100%), sesudah diberi manajemen intervensi body wipe suhu normal (91.7%)  dan suhu tinggi (8.3%), umur fase menopause (100%), pendidikan bawah (100%), pekerjaan secara mandiri (100%). Untuk analisis bivariat terdapat 12 wanita menopause (100%) dengan hasil suhu inti tubuh lebih rendah setelah diberi manajemen intervensi body wipe dibandingkan sebelum diberi manajemen intervensi body wipe. Hasil penelitian ini menunjukan bahwa manajemen intervensi dengan menggunakan body wipe dapat berpengaruh dalam mengatasi hot flush pada ibu menopause di Klinik/BP Anisa dengan nilai nilai p= 0,001. Body wipe dapat digunakan sebagai manajemen intervensi untuk mengatasi hot flush.

Hot flush over in a flash

Nature ◽  
2001 ◽  
Author(s):  
Philip Ball
Keyword(s):  
Hot Flush

scholarly journals ICI 182,780 Penetrates Brain and Hypothalamic Tissue and Has Functional Effects in the Brain after Systemic Dosing

Endocrinology ◽  
2008 ◽  
Vol 149 (10) ◽  
pp. 5219-5226 ◽  
Author(s):  
Peter D. Alfinito ◽  
Xiaohong Chen ◽  
James Atherton ◽  
Scott Cosmi ◽  
Darlene C. Deecher
Keyword(s):  
Body Weight ◽  
Skin Temperature ◽  
Ethinyl Estradiol ◽  
Ovariectomized Rats ◽  
Ici 182,780 ◽  
Hot Flush ◽  
Hypothalamic Tissue ◽  
Dependent Model ◽  
The Brain ◽  
Neuroendocrine Functions

Previous reports suggest the antiestrogen ICI 182,780 (ICI) does not cross the blood-brain barrier (BBB). However, this hypothesis has never been directly tested. In the present study, we tested whether ICI crosses the BBB, penetrates into brain and hypothalamic tissues, and affects known neuroendocrine functions in ovariectomized rats. Using HPLC with mass spectrometry, ICI (1.0 mg/kg·d, 3 d) was detected in plasma and brain and hypothalamic tissues for up to 24 h with maximum concentrations of 43.1 ng/ml, and 31.6 and 38.8 ng/g, respectively. To evaluate antiestrogenic effects of ICI in the brain after systemic dosing, we tested its ability to block the effect of 17 α-ethinyl estradiol (EE) (0.3 mg/kg, 8 d) on tail-skin temperature abatement in the morphine-dependent model of hot flush and on body weight change. In the morphine-dependent model, EE abated 64% of the naloxone-induced tail-skin temperature increase. ICI pretreatment (1.0, 3.0 mg/kg·d) dose dependently inhibited this effect. ICI (3.0 mg/kg·d) alone showed estrogenic-like actions, abating 30% the naloxone-induced flush. In body weight studies, EE-treated rats weighed 58.5 g less than vehicle-treated rats after 8 d dosing. This effect was partially blocked by ICI (3.0 mg/kg·d) pretreatment. Similar to EE treatment, rats receiving 1.0 or 3.0 mg/kg·d ICI alone showed little weight gain compared with vehicle-treated controls. Thus, ICI crosses the BBB, penetrates into brain and hypothalamic tissues, and has both antiestrogenic and estrogenic-like actions on neuroendocrine-related functions.

Physiological aspects of menopausal hot flush

BMJ ◽  
1978 ◽  
Vol 2 (6135) ◽  
pp. 501-501
Author(s):  
J. R Clayden
Keyword(s):  
Hot Flush

Time to transient and stable reductions in hot flush frequency in postmenopausal women using conjugated estrogens/bazedoxifene

2017 ◽  
Vol 24 (9) ◽  
pp. 1011-1016
Author(s):  
JoAnn V. Pinkerton ◽  
Andrew G. Bushmakin ◽  
Lucy Abraham ◽  
Barry S. Komm ◽  
Joel Bobula
Keyword(s):  
Postmenopausal Women ◽  
Conjugated Estrogens ◽  
Hot Flush

Regional skin temperature changes in a rat model for the menopausal hot flush

Maturitas ◽  
1986 ◽  
Vol 8 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Michael J. Katovich ◽  
James W. Simpkins ◽  
Lee Ann Berglund ◽  
June O'Meara
Keyword(s):  
Skin Temperature ◽  
Rat Model ◽  
Temperature Changes ◽  
Hot Flush

Frequency, management, and resource use of adverse events (AEs) in nonmetastatic castrate-resistant prostate cancer (nmCRPC) patients receiving apalutamide or enzalutamide: A real-world study.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 217-217
Author(s):  
Shan Jiang ◽  
Della Varghese ◽  
Sreevalsa Appukkuttan ◽  
Shelby Corman ◽  
Nehemiah Kebede ◽  
...  
Keyword(s):  
Resource Use ◽  
Real World ◽  
Descriptive Analysis ◽  
Specific Antigen ◽  
Retrospective Chart Review ◽  
The United States ◽  
Patient Decision Making ◽  
Hot Flush ◽  
Initial Cohort ◽  
Frequency Management

217 Background: Second generation androgen receptor inhibitors (SGARIs), apalutamide (APA) and enzalutamide (ENZ) and darolutamide, are approved in the United States (US) for the treatment of nmCRPC. The objectives of this study were to describe the frequency of AEs and actions taken to manage AEs among nmCRPC patients treated with APA or ENZ and their downstream resource implications. Methods: This is a further descriptive analysis of a retrospective chart review study conducted in 43 US nmCRPC-treating sites. In our sample, the 43 physicians identified 699 nmCRPC patients initiating treatment with APA (N = 368) or ENZ (N = 333) with 2 patients receiving both, between February 1, 2018 and December 31, 2018 and AEs were collected as reported in regular clinical practice. A representative subset of patients, experiencing at least 1 AE for either APA (N = 125) or ENZ (N = 125), were selected randomly from the initial cohort, and their detailed chart data were extracted to understand the actions taken to manage AEs. Results: Of the initial cohort of nmCRPC patients, 72.0% and 78.7% of men receiving APA (N = 368) and ENZ (N = 333) experienced ≥1 AE, respectively. The three most common AEs reported were fatigue/asthenia (APA, 30.2%; ENZ, 38.7%), hot flush (APA, 14.1%; ENZ, 13.5%), and arthralgia (APA, 14.4%; ENZ, 12.9%). Cognitive and mental changes were observed in 5.4% (APA) and 7.8% (ENZA) men. The subset analysis of randomly selected patients experiencing ≥1 AE (APA, 125; ENZ, 125) were mostly Caucasian (APA, 72.8%; ENZ, 71.2%), ECOG score 0-1 (APA, 84%; ENZ, 88%), median prostate specific antigen (PSA) value 13 ng/ml and 11 ng/ml (APA, ENZ; respectively). Actions to address AEs included treatment of AE, SGARI discontinuation, dose reduction and hospitalization (Table). Specifically, treatment discontinuation due to AE was observed in 8.0% (APA) and 12.8 (%) of men. AEs were often not resolved (APA, 43.6%; ENZ, 39.4%), and the median duration of days to resolve AEs were 60.0 for APA and 56.0 for ENZ. Conclusions: This real-world study highlights the clinical and resource use burden of AEs among nmCRPC patients treated with APA and ENZ. The results demonstrate the importance of safety and tolerability as key considerations in shared clinician-patient decision-making regarding SGARI therapy in nmCRPC. [Table: see text]

PENGARUH ISOFLAVON SARI TEMPE KENTAL MANIS TERHADAP PENINGKATAN KADAR ESTRADIOL SERUM PADA IBU PRA MENOPAUSE DI SDN DAN SMPN KECAMATAN SUKAJADI PEKANBARU TAHUN 2016

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
SURYATNI SURYATNI ◽  
YAN SARTIKA ◽  
MUKHAMAD ANGWAR
Keyword(s):  
Random Sampling ◽  
Hot Flush

Penurunan kadar estradiol pada masa pra menopouse menyebabkan berbagai perubahan pada fisik dan psikis. Perubahan yang dirasakan antara lain perubahan pola mestruasi, hot flush (rasa panas), insomnia, depresi, sakit kepala, nyeri tulang dan vagina kering. Untuk mencegah hal ini maka diupayakan aternatif lain yang lebih bersifat natural yaitu dengan memberikan isoflavon alami. Kedelai mengandung isoflavon, salah satu bahan pangan yang terbuat dari kedelai adalah tempe. Pada tempe terdapat empat jenis isoflavon yaitu daidzein, glisitein dan genistein dan antioksidan faktor II (6,7,4- trihidroksi isoflavon). Tujuan penelitian untuk mengetahui pengaruh  isoflavon  sari tempe  kental  manis  terhadap peningkatan kadar estradiol serum pada ibu pra menopause di SDN dan SMPN Kecamatan Sukajadi Pekanbaru tahun 2016. Desain penelitian adalah quasy-eksperimen yang bersifat one group pretest-postest, observasional terhadap 13 orang ibu pra menopause di SDN dan SMPN Kecamatan Sukajadi Pekanbaru, April – November 2016. Sampel dipilih dengan menggunakan teknik random sampling. Pemeriksaan kadar estradiol dilakukan dilaboratorium Awal Bross Pekanbaru dengan metode Architect Estradiol. Uji normalitas data dengan Shapiro-Wilk, uji pengaruh isoflavon sari tempe kental manis terhadap peningkatan kadar estradiol dengan  menggunakan uji Wilcoxon. Hasil penelitian menunjukkan median kadar estradiol pada pretest adalah 24 (10-114) pg/ml dan median kadar etradiol pada postest adalah 72 (10-191) pg/ml. Terdapat pengaruh yang signifikan antara pemberian isoflavon sari tempe kental manis terhadap peningkatan kadar estradiol (p= 0,025). Kesimpulan penelitian ini adalah semakin sering diberikan isoflavon sari tempe kental manis maka semakin tinggi kadar estradiol sehingga dapat mengurangi perubuhan fisik dan psikis pada ibu pra menopause .

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