Perbandingan Oedema Paru Akut Yang Disebabkan Oleh Tingkat Kardiogenik dan Non Kardiogenik Dengan Mortalitas Dan Morbiditas Pasien

Care Journal ◽  
2022 ◽  
Vol 1 (1) ◽  
pp. 19-33
Author(s):  
Taufik Salis Syaifudin ◽  
Rizqi Asri Fauzi Nugraha ◽  
Indra Lasmana Tarigan Tarigan
Keyword(s):  
Creatine Kinase ◽  
Creatine Kinase Mb

Latar Belakang: Prognosis jangka panjang edema paru akut (APE) tetap tidak jelas. Metode dan Hasil: Kami mengevaluasi data demografis, ekokardiografi, dan angiographic dari 806 pasien berturut-turut dengan APE dengan (CAD) dan tanpa penyakit arteri koroner (non-CAD) yang diterima dari tahun 2000 hingga 2010. Perbedaan antara rumah sakit dan kematian jangka panjang dan prediktornya juga dinilai. Pasien CAD (n = 638) lebih tua dan memiliki insiden diabetes dan penyakit vaskular perifer yang lebih tinggi daripada non-CAD (n = 168), dan fraksi ejeksi yang lebih rendah. Kematian di rumah sakit serupa pada kedua kelompok (26,5% vs 31,5%; P = 0,169) tetapi kekambuhan KERA lebih tinggi pada pasien CAD (17,3% vs 6,5%; P<0.001).  Usia, masuk tekanan darah sistolik, kekambuhan APE, dan kebutuhan inotropics atau intubasi endotrakcheal adalah prediktor independen utama kematian di rumah sakit. Sebaliknya, kematian secara keseluruhan (70,0% vs 57,1%; P = 0,002) dan penerimaan kembali untuk gagal jantung nonfatal setelah tindak lanjut 45 bulan (10-140; 17,3% vs 7,6%; P = 0,009) lebih tinggi pada CAD daripada pasien non-CAD. Usia, penyakit vaskular perifer, dan puncak creatine kinase MB selama rawat inap indeks, tetapi bukan fraksi ejeksi, adalah prediktor independen utama dari kematian secara keseluruhan, sedangkan revaskularisasi koroner atau operasi valvular bersifat protektif. Intervensi ini sebagian besar dilakukan selama indeks rawat inap (294 dari 307; 96%) dan tidak pasien yang diintervensi menunjukkan profil risiko yang lebih tinggi.  Kesimpulan: Kematian jangka panjang di APE tinggi dan lebih tinggi pada CAD daripada pada pasien non-CAD. Mengingat prediktor kematian di rumah sakit dan jangka panjang yang berbeda di sini dijelaskan, yang tidak selalu melibatkan fungsi sistolik, dapat dibayangkan bahwa program intervensi yang lebih agresif dapat meningkatkan kelangsungan hidup pada pasien berisiko tinggi.

Serum Cardiac Troponin T and Creatine Kinase–MB Elevations in Murine Autoimmune Myocarditis

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1927-1932 ◽  
Author(s):  
Kurt Bachmaier ◽  
Johannes Mair ◽  
Felix Offner ◽  
Christian Pummerer ◽  
Nikolaus Neu
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Autoimmune Myocarditis ◽  
Creatine Kinase Mb ◽  
Serum Cardiac Troponin

Modifications in the Concentrations of Circulating Myoglobin after Treatment with Low Doses of Adriamycin

1985 ◽  
Vol 71 (5) ◽  
pp. 463-468 ◽  
Author(s):  
Giovanni Carulli ◽  
Aldo Clerico ◽  
Alessandra Marini ◽  
Maria Grazia Del Chicca ◽  
Renato Vanacore ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Cancer Patients ◽  
Muscle Damage ◽  
Low Doses ◽  
Skeletal Muscle Damage ◽  
Creatine Kinase Mb

The modifications in the concentration of circulating myoglobin have been studied by means of a radioimmunoassay in 15 cancer patients undergoing polychemotherapy including adriamycin. In 8 patients significant increases in myoglobin levels were found after injection of low doses of the drug (25-50 mg/m2). Moreover, a disturbance of the normal biorhythm of the protein was evident in 12 patients. Creatine kinase-MB was evaluated by means of a radioimmunoassay, but there was no relation between an increase in the isoenzyme and an increase in myoglobin. No ECG modifications were detected. These data indicate that the measurement of myoglobin may offer an indication of myocardial or skeletal muscle damage caused by adriamycin.

scholarly journals Interference of ascorbic acid with chemical analytes

2005 ◽  
Vol 42 (6) ◽  
pp. 475-477 ◽  
Author(s):  
Qing H Meng ◽  
William C Irwin ◽  
Jennifer Fesser ◽  
K Lorne Massey
Keyword(s):  
Ascorbic Acid ◽  
Creatine Kinase ◽  
Uric Acid ◽  
Total Cholesterol ◽  
Acid Concentration ◽  
Total Bilirubin ◽  
Binding Capacity ◽  
Ascorbic Acid Concentration ◽  
Sodium Potassium ◽  
Creatine Kinase Mb

Background: Ascorbic acid can interfere with methodologies involving redox reactions, while comprehensive studies on main chemistry analysers have not been reported. We therefore attempted to determine the interference of ascorbic acid with analytes on the Beckman Synchron LX20®. Methods: Various concentrations of ascorbic acid were added to serum, and the serum analytes were measured on the LX20. Results: With a serum ascorbic acid concentration of 12.0 mmol/L, the values for sodium, potassium, calcium and creatinine increased by 43%, 58%, 103% and 26%, respectively ( P<0.01). With a serum ascorbic acid concentration of 12.0 mmol/L, the values for chloride, total bilirubin and uric acid decreased by 33%, 62% and 83%, respectively ( P<0.01), and were undetectable for total cholesterol, triglyceride, ammonia and lactate. There was no definite influence of ascorbic acid on analytical values for total CO2, urea, glucose, phosphate, total protein, albumin, amylase, creatine kinase, creatine kinase-MB, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total iron, unbound iron-binding capacity or magnesium. Conclusions: Ascorbic acid causes a false increase in sodium, potassium, calcium and creatinine results and a false decrease in chloride, total bilirubin, uric acid, total cholesterol, triglyceride, ammonia and lactate results.

Isolated creatine kinase-MB rise with normal cardiac troponins

2011 ◽  
Vol 12 (10) ◽  
pp. 736-740 ◽  
Author(s):  
Fabrizio Ricci ◽  
Raffaele De Caterina
Keyword(s):  
Creatine Kinase ◽  
Creatine Kinase Mb ◽  
Cardiac Troponins

Troponin T is a better predictor than creatine kinase-MB of long-term mortality after coronary artery bypass graft surgery

2012 ◽  
Vol 164 (5) ◽  
pp. 779-785 ◽  
Author(s):  
Camilla Lund Søraas ◽  
Charlotte Friis ◽  
Kristin Victoria Tunheim Engebretsen ◽  
Leiv Sandvik ◽  
Sverre Erik Kjeldsen ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Troponin T ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Creatine Kinase Mb ◽  
Long Term Mortality

ASSOCIATION OF SERUM LACTATE LEVELS WITH CREATINE KINASE – MB AND LACTATE DEHYDROGENASE IN PATIENTS WITH MYOCARDIAL INFARCTION

2021 ◽  
pp. 73-75
Author(s):  
Mallaiyan Manonmani ◽  
Meiyappan Kavitha
Keyword(s):  
Myocardial Infarction ◽  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Serum Lactate ◽  
Serum Creatine Kinase ◽  
Hemodynamic Management ◽  
Diagnosis And Prognosis ◽  
Creatine Kinase Mb ◽  
Enzymatic Markers ◽  
Lactate Levels

Objectives: Myocardial infarction is the most common form of coronary heart disease, the commonest cause of worldwide mortality. The present biochemical markers take atleast 6 hours for elevation following an episode of myocardial infarction. There is a need for sensitive marker for early diagnosis and prognosis. Lactate, the end product of anaerobic glycolysis is found to be elevated in many critical illnesses. Thus the study was undertaken to assess the levels of serum lactate in patients with myocardial infarction and to correlate it with the frequently used enzymatic markers for the diagnosis of myocardial infarction, i.e creatine kinase – MB and lactate dehydrogenase Methods: Fifty age and sex matched controls and fty cases of myocardial infarction were included in the study. Serum creatine kinase – MB, lactate dehydrogenase and lactate were estimated in these subjects. Results:The serum lactate levels were signicantly higher among cases when compared to controls. The serum lactate levels positively correlated with serum creatine kinase – MB among cases but not with lactate dehydrogenase. Conclusions: We conclude that serum lactate is altered in patients with myocardial infarction and may be considered as a prognostic risk factor in these patients. Further studies are needed to nd the cut-off value of serum lactate for assistance in the hemodynamic management of these patients.

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