scholarly journals THE DIAGNOSTIC ROLE OF FETAL HEMOGLOBIN AND BLOOD OXYGEN SATURATION IN CHRONIC LIVER DISEASES

2021 ◽  
Vol 11 (4) ◽  
pp. 77-78
Author(s):  
Boleslav Levitan ◽  
Vsevolod Skvortsov ◽  
Тatiana Kasyanova ◽  
Maksim Vozniuk
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Oxygen Saturation ◽  
Liver Diseases ◽  
Sodium Dodecyl ◽  
Fetal Hemoglobin ◽  
Control Group ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Diagnostic Role

This research aims to study levels of fetal hemoglobin and blood oxygen saturation in 264 patients with chronic diffuse liver diseases, among them 69 patients with chronic hepatitis and 195 patients with liver cirrhosis. To determine the levels of fetal hemoglobin, a patented method of rocket electrophoresis in agar gel with sodium dodecyl sulfate was used. The level of fetal hemoglobin in liver cirrhosis were significantly increased compared to chronic hepatitis, and, in both cases, compared with the control group. Oxygen saturation of the blood was reduced mainly in liver cirrhosis. In patients with liver cirrhosis a relationship between fetal hemoglobin and oxygen saturation was established. Our study helps in the early diagnosis of latent chronic hypoxia and hypoxemia in patients with liver disease. This allows to assess disease severity and adjust the treatment

scholarly journals Effect of Semi-Recumbent Position on Blood Oxygen Saturation in Postanesthetic Patients After Laparoscopic Cholecystectomy

2018 ◽  
Vol 12 (3) ◽  
pp. 82-85
Author(s):  
Xiaoling Chen ◽  
Yuelan Qin ◽  
Fanghua Gong
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Lung Function ◽  
Oxygen Saturation ◽  
Intervention Group ◽  
Control Group ◽  
Blood Oxygen ◽  
Recumbent Position ◽  
Blood Oxygen Saturation ◽  
Bed Elevation ◽  
Before And After

BackgroundUndergoing general anesthesia and pneumoperitoneum could affect the lung function and comprise oxygenation in laparoscopic cholecystectomy patients. Position of patients after surgery may affect lung function of these patients.AimTo observe the effect of semi-recumbent position on blood oxygen saturation (SpO2) in postanesthetic patients after laparoscopic cholecystectomy.MethodsA number of 225 patients who admitted to postanesthetic care unit after laparoscopic cholecystectomy from September 2016 to May 2017 were randomly assigned into the intervention group and the control group. The intervention group adopted a semi-recumbent position with head bed elevation by 10 to 20°, while the control received a supine position without lying on a pillow. Both groups received routine postanesthesia care. Data on SpO2 before and after extubation were collected. Independent t-test was used for data analysis.ResultsThere was no vomiting and cough reactions before and after extubation in both groups. Intervention group reported a significantly higher level of SpO2 at 1 minute and 30 minutes after extubation, compared to the control group (both ps < 0.05).ConclusionSemi-recumbent position with the head bed elevation could significantly increase the SpO2 level of postanesthetic patients, thus ensuring the safety of patients when removing the endotracheal tube.

Adaptation to altitude as a vehicle for experiential learning of physiology by university undergraduates

2007 ◽  
Vol 31 (3) ◽  
pp. 270-278 ◽  
Author(s):  
David S. Weigle ◽  
Amelia Buben ◽  
Caitlin C. Burke ◽  
Nels D. Carroll ◽  
Brett M. Cook ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cognitive Function ◽  
Experiential Learning ◽  
Oxygen Saturation ◽  
Learning Activity ◽  
Control Group ◽  
Research Station ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
University Undergraduates

In this article, an experiential learning activity is described in which 19 university undergraduates made experimental observations on each other to explore physiological adaptations to high altitude. Following 2 wk of didactic sessions and baseline data collection at sea level, the group ascended to a research station at 12,500-ft elevation. Here, teams of three to four students measured the maximal rate of oxygen uptake, cognitive function, hand and foot volume changes, reticulocyte count and hematocrit, urinary pH and 24-h urine volume, athletic performance, and nocturnal blood oxygen saturation. Their data allowed the students to quantify the effect of altitude on the oxygen cascade and to demonstrate the following altitude-related changes: 1) impaired performance on selected cognitive function tests, 2) mild peripheral edema, 3) rapid reticulocytosis, 4) urinary alkalinization and diuresis, 5) impaired aerobic but not anaerobic exercise performance, 6) inverse relationship between blood oxygen saturation and resting heart rate, and 7) regular periodic nocturnal oxygen desaturation events accompanied by heart rate accelerations. The students learned and applied basic statistical techniques to analyze their data, and each team summarized its results in the format of a scientific paper. The students were uniformly enthusiastic about the use of self-directed experimentation to explore the physiology of altitude adaptation and felt that they learned more from this course format than a control group of students felt that they learned from a physiology course taught by the same instructor in the standard classroom/laboratory format.

Feasibility study of morphine-induced rat pica model by tail vein injection to replace vomiting model

2020 ◽  
Vol 20 (5) ◽  
pp. 364-366
Author(s):  
Weijian ZHOU ◽  
◽  
Pengju BAO ◽  
Wenjun GUO ◽  
Ting HONG ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Effective Dose ◽  
Statistical Significance ◽  
Control Group ◽  
Blood Oxygen ◽  
Blank Control Group ◽  
Blood Oxygen Saturation ◽  
Treatment Groups ◽  
Tail Vein ◽  
Tail Vein Injection

Objective： To explore the feasibility of the morphine-induced rat pica model by tail vein injection to replace the vomiting model，and the effective dose of morphine with less severe complications when the model was developed.Methods： Fifty SD rats were randomly divided into the blank control group and the M1，M2，M3 and M4 groups，each consisting of 10 animals. The rats in the blank control group were injected with 10 ml/kg normal saline（NS） via tail vein，while the animals in the M1，M2，M3 and M4 groups were injected with morphine hydrochloride injection at a dosage of 5，10，20 and 30 mg/kg via tail vein.Heart rate，blood oxygen saturation and activities of the animals were closely observed and recorded at 5，10 and 15 minutes after medication.Then，changes in the intake of kaolin，feed and water of the rats in each group were recorded and compared between the groups for 4 successive days after medication.Results： The blood oxygen saturation in the morphine treatment groups all reduced significantly，and statistical significance could be seen，when it was compared with that of the blank control group（P<0.05）.On the first day after medication，the intake of kaolin in the M3 and M4 groups increased significantly，as compared with that of the blank control group（P<0.05）.On the third day after medication，the intake of kaolin in the M1 group significantly increased，as compared with that of the blank control group（P<0.05）.Conclusion： The rat pica model was established by tail vein injection of morphine，which could be used to replace the vomiting model.The effective dose of morphine was 20 mg/kg with less severe complications.

scholarly journals A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study

2017 ◽  
Vol 55 (3) ◽  
pp. 129-137 ◽  
Author(s):  
Milica Obradovic ◽  
Zoran Gluvic ◽  
Nina Petrovic ◽  
Milan Obradovic ◽  
Ratko Tomasevic ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Pilot Study ◽  
Liver Diseases ◽  
Alcoholic Hepatitis ◽  
Chronic Liver ◽  
Control Group ◽  
Chronic Liver Diseases ◽  
Healthy Control

Abstract Introduction. Chronic liver diseases (CLD) are an important cause of morbidity and mortality in general population. The aim of this study was to analyze potential differences between patients with CLD and healthy control group, and to estimate the severity of CLD by using simple questionnaires: general health questionnaire (GHQ-12) and chronic liver disease questionnaire (CLDQ). Methods. A cross-sectional pilot study was performed in Zemun Clinical Hospital during years 2014 and 2015. Sixty participants were divided into 4 groups (15 per group): chronic alcoholic hepatitis, other chronic hepatitis, liver cirrhosis, and healthy control group. Entire study population chose one of four offered answers of structured questionnaires GHQ-12 and CLDQ, based on which mean model of end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores were calculated. Results. Mean GHQ12 and CLDQ scores were 10.5 and 5.21 ± 1.11 respectively. Regarding certain CLDQ domain scores, a significant difference between alcoholic and non-alcoholic hepatitis groups in the worry domain was observed. Mean MELD score was 7.42 ± 2.89 and did not differ between chronic hepatitis groups, while mean CTP score was 5.73 ± 0.88. A statistically significant correlation was observed between GHQ12 and CLDQ scores (ρ = -0.404, p < 0.01), but not between subjective and objective scores. Conclusions. Mean GHQ12 and CLDQ scores pointed out to general psychological no-distress condition of the studied participants, as well as scarcely expressed CLD-specific complaints. Mean MELD and CTP scores indicated stable chronic liver diseases, with low three-month mortality rates in the cases of chronic hepatitis, as well as determination to Child A group in the case of liver cirrhosis.

scholarly journals Propofol Combined with Fentanyl Is Superior to Propofol Alone in Sedation Protocols for Painless Gastrointestinal Endoscopy

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jie Chang ◽  
Chun Yang
Keyword(s):  
Heart Rate ◽  
Oxygen Saturation ◽  
Recovery Time ◽  
Gastrointestinal Endoscopy ◽  
Outcome Analysis ◽  
Control Group ◽  
Observation Group ◽  
Blood Oxygen ◽  
Sleep State ◽  
Blood Oxygen Saturation

Sufficient propofol or fentanyl doses necessary to prevent the response to skin incision do not necessarily reduce hemodynamic responses during surgery. The purpose of this study was to characterize the pharmacodynamic interaction between propofol and fentanyl with respect to the sedative effects and safety during painless gastrointestinal endoscopy. From October 2018 to October 2020, 200 patients undergoing painless gastrointestinal endoscopy in our department’s outpatient or inpatient clinic were selected and randomly divided into a control group and an observation group, 100 patients per group. Prior to surgery, the patients in the two groups were required to be connected to an electrocardiogram monitor and then were instructed to lie on the left side and receive continuous oxygen infusion of 2-3 L/min with a nasal cannula. The control group was injected with propofol injection (100 mg/min). The observation group was given fentanyl intravenous injection at a dose of 0.1 μg/kg followed by propofol injection (100 mg/min). Painless gastrointestinal endoscopy was performed after the patients entered a sleep state and the eyelash reaction disappeared. Outcome analysis was performed on preoperative and intraoperative hemodynamic indicators, including heart rate, blood oxygen saturation, dose of propofol, time for endoscopy, recovery time, hospitalization after recovery, Montreal Cognitive Assessment (MoCA) score, and Mini-Mental State Examination (MMSE) score. The incidence rate of adverse reactions in the observation group was 6%, which was notably lower than that of the control group (18%). The total response rate of the observation group was 98%, which was significantly higher than that of the control group (90%) ( P < 0.05 ). The intraoperative heart rate and blood oxygen saturation of the observation group were higher than those of the control group ( P < 0.0 ss ). The patients receiving sedation with propofol plus fentanyl had fewer doses of propofol and shorter recovery time than those receiving propofol alone ( P < 0.05 ). It was also revealed that the patients receiving sedation with propofol plus fentanyl exhibited more MoCA and MMSE scores than those receiving propofol alone 30 min after sedation during painless gastrointestinal endoscopy. Taken together, sedation with propofol combined with fentanyl was more effective and safer than that with propofol alone in painless gastrointestinal endoscopy, which can ensure a wake-up state, stable breathing cycle, and better gastrointestinal painless procedure.

scholarly journals Stimulating Effect of Aromatherapy Massage with Jasmine Oil

2010 ◽  
Vol 5 (1) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Tapanee Hongratanaworakit
Keyword(s):  
Blood Pressure ◽  
Oxygen Saturation ◽  
Control Group ◽  
Breathing Rate ◽  
Blood Oxygen ◽  
Behavioral Arousal ◽  
Blood Oxygen Saturation ◽  
Jasminum Sambac ◽  
Emotional Level ◽  
Emotional Condition

The aim of this study was to investigate the effect of aromatherapy massage with jasmine oil (Jasminum sambac L., Oleaceae) on humans. Human autonomic parameters, i.e. blood pressure, pulse rate, blood oxygen saturation, breathing rate, and skin temperature, were recorded as indicators of the arousal level of the autonomic nervous system. In addition, subjects had to rate their emotional condition in terms of relaxation, vigor, calmness, attentiveness, mood, and alertness in order to assess subjective behavioral arousal. Forty healthy volunteers participated in the experiments. Jasmine oil was applied topically to the skin of the abdomen of each subject. Compared with placebo, jasmine oil caused significant increases of breathing rate, blood oxygen saturation, and systolic and diastolic blood pressure, which indicated an increase of autonomic arousal. At the emotional level, subjects in the jasmine oil group rated themselves as more alert, more vigorous and less relaxed than subjects in the control group. This finding suggests an increase of subjective behavioral arousal. In conclusion, our results demonstrated the stimulating/activating effect of jasmine oil and provide evidence for its use in aromatherapy for the relief of depression and uplifting mood in humans.

scholarly journals Intriguing findings of liver fibrosis following COVID-19

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Oksana Kolesova ◽  
Ieva Vanaga ◽  
Sniedze Laivacuma ◽  
Aleksejs Derovs ◽  
Aleksandrs Kolesovs ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Oxygen Saturation ◽  
Liver Stiffness ◽  
Liver Function Tests ◽  
Ultrasound Elastography ◽  
Control Group ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Liver Fibrogenesis ◽  
Liver Fibrosis Index

Abstract Background Studies on a new coronavirus disease (COVID-19) show the elevation of liver enzymes and liver fibrosis index (FIB-4) independently on pre-existing liver diseases. It points to increased liver fibrogenesis during acute COVID-19 with possible long-term consequences. This study aimed to assess liver fibrosis in COVID-19 patients by serum hyaluronic acid (HA) and FIB-4. Methods The study included the acute COVID-19 group (66 patients, 50% females, mean age 58.3 ± 14.6), the post-COVID group (58 patients in 3–6 months after the recovery, 47% females, mean age 41.2 ± 13.4), and a control group (17 people, 47% females, mean age 42.8 ± 11.0). Ultrasound elastography was performed in the post-COVID and control groups. Results Sixty-five percent of the acute COVID-19 group had increased FIB-4 (> 1.45), and 38% of patients had FIB-4 ≥ 3.25. After matching by demographics, 52% of acute COVID-19 and 5% of the post-COVID group had FIB-4 > 1.45, and 29% and 2% of patients had FIB-4 ≥ 3.25, respectively. Increased serum HA (≥ 75 ng/ml) was observed in 54% of the acute COVID-19 and 15% of the post-COVID group. In the acute COVID-19 group, HA positively correlated with FIB-4, AST, ALT, LDH, IL-6, and ferritin and negatively with blood oxygen saturation. In the post-COVID group, HA did not correlate with FIB-4, but it was positively associated with higher liver stiffness and ALT. Conclusion More than half of acute COVID-19 patients had increased serum HA and FIB-4 related to liver function tests, inflammatory markers, and blood oxygen saturation. It provides evidence for the induction of liver fibrosis by multiple factors during acute COVID-19. Findings also indicate possible liver fibrosis in about 5% of the post-COVID group.

scholarly journals ALGORITHM OF DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF CHRONIC DIFFUSE LIVER DISEASES (CHRONIC HEPATITIS AND LIVER CIRRHOSIS) IN DIFFICULT CLINICAL SITUATIONS, BASED ON DETERMINATION OF ENZYMATIC ACTIVITIES OF BLOOD SERUM

2020 ◽  
Vol 8 (4) ◽  
pp. 566-573
Author(s):  
H.I. Yupatov ◽  
◽  
V.A. Pryshchepenko ◽  
Keyword(s):  
Differential Diagnosis ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Blood Serum ◽  
Liver Diseases ◽  
Laboratory Research ◽  
Control Group ◽  
Diagnostic Measures ◽  
Diffuse Liver Diseases

Background. The search for non-invasive criteria for differential diagnosis of chronic hepatitis and liver cirrhosis is one of the urgent tasks of hepatology. Aim. Development of an algorithm for the diagnosis and differential diagnosis of chronic diffuse liver diseases (chronic hepatitis and liver cirrhosis) in difficult clinical situations, namely in patients with questionable results of routine laboratory research. Materials and Methods. 55 patients were examined who had a characteristic clinical picture of chronic diffuse liver diseases, however, the levels of AST and ALT were close to normal values. Chronic hepatitis was confirmed in 14 patients (mean age 55.0±11.2 years), liver cirrhosis in 40 patients (mean age 55.0±9.9 years). The control group included 43 practically healthy individuals (mean age – 52.8±4.2 years). All patients underwent determination of the levels of hyaluronidase, elastase, trypsin-like and deoxyribonuclease serum activities, as well as levels of alpha-1-defensin and interleukin-13 in blood serum. Results. An algorithm for the differential diagnosis of chronic hepatitis and cirrhosis of the liver was developed, which makes it possible to identify liver disease with odds ratio of 988.0 [CI95%=31.3-31207.7]. Conclusion. The algorithm allows to optimize diagnostic measures in difficult clinical situations.

Assessment of miR-212 and Other Biomarkers in the Diagnosis and Treatment of HBV-infection-related Liver Diseases

2019 ◽  
Vol 20 (10) ◽  
pp. 785-798 ◽  
Author(s):  
Yigan Zhang ◽  
Huaze Xi ◽  
Xin Nie ◽  
Peng Zhang ◽  
Ning Lan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Liver Cancer ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Liver Diseases ◽  
Meld Score ◽  
Hbv Infection ◽  
Expression Level ◽  
Control Group

Objective: Our study aims to detect the sensitivity of the new biomarker miR-212 existing in serum exosomes along with other hepatocellular carcinoma biomarkers such as AFP (alpha-fetoprotein), CA125 (carbohydrate antigen-ca125), and Hbx protein in the diagnosis of HBV-related liver diseases. We also aim to study the roles of these biomarkers in the progression of chronic hepatitis B and provide scientific data to show the clinical value of these biomarkers. Methods: We selected 200 patients with HBV-infection (58 cases of chronic hepatitis B, 47 cases of hepatocellular carcinoma, 30 cases of compensatory phase cirrhosis, and 65 cases of decompensatory phase cirrhosis), 31 patients with primary liver cancer without HBV infection, and 70 healthy individuals as the control group. The expression level of serum AFP and CA125 was detected with electrochemiluminescence immunoassay. The expression level of the Hbx protein was detected with ELISA. Meanwhile, the expression level of miR-212 in serum was analyzed with RT-qPCR. We collected patients’ clinical information following the Child-Pugh classification and MELD score criterion, and statistical analysis was made between the expression level of miR-212 and the collected clinical indexes. Lastly, we predicted the target genes of the miR-212 and its functions using bioinformatics methods such as cluster analysis and survival prediction. Results: Compared to the control group, the expression level of miR-212 in HBV infected patients was remarkably increased (P<0.05), especially between the HBV-infection Hepatocellular carcinoma group and the non-HBVinfection liver cancer group (P<0.05). The expression of miR-212 was increased in patients’ Child-Pugh classification, MELD score, and TNM staging. Moreover, the sensitivity and specificity of miR-212 were superior to AFP, CA125, and HBx protein. Conclusion: There is a linear relationship between disease progression and expression level of miR-212 in the serum of HBV infected patients. This demonstrates that miR-212 plays a significant role in liver diseases. miR-212 is expected to be a new biomarker used for the diagnosis and assessment of patients with HBV-infection-related liver diseases.

scholarly journals PSIX-9 Impacts of bunk management on feedlot performance, carcass characteristics, hydrogen sulfide concentration and blood oxygen saturation in steers fed 25 or 50% modified distillers grains plus solubles

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 422-422
Author(s):  
Rebecca L Moore ◽  
Cierrah J Kassetas ◽  
Leslie A LeKatz ◽  
Bryan W Neville
Keyword(s):  
Hydrogen Sulfide ◽  
Oxygen Saturation ◽  
Management Strategy ◽  
Distillers Grains ◽  
Feed Ratio ◽  
Sulfide Concentration ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Feedlot Performance ◽  
Arterial Blood

Abstract One hundred and twenty-six yearling angus steers (initial body weight 445.87 ± 7.13 kg) were utilized in a 2 x 2 factorial design to evaluate the impacts of bunk management and modified distillers grains plus solubles (mDGS) inclusion on feedlot performance, hydrogen sulfide concentrations and blood oxygen saturation. Treatments included bunk management strategy either control bunk management (CON; clean bunks at the time of next day’s feeding) or long bunk management (LONG; feed remaining at time of next day’s feeding), and two inclusion rates of mDGS either 25% or 50% (DM Basis). On d 0, 7, 14, 21, 28 and 35 rumen gas samples were collected via rumenocentesis, and arterial blood samples were collected on two steers from each pen. No differences (P ≥ 0.09) were observed for dry matter intake, average daily gain and gain-to-feed ratio for bunk management or mDGS inclusion. Hot carcass weight, ribeye area, marbling score and quality grade were not affected (P ≥ 0.48) by either bunk management or mDGS inclusion. Back fat was greater (P = 0.04) for CON steers compared to LONG (1.30 vs 1.12 ± 0.05cm, respectively), but was not affected (P = 0.59) by mDGS inclusion. Steers on CON had greater (P = 0.03) yield grades compared to LONG (3.21 vs 2.96 ± 0.11, respectively). Bunk management strategy did not impact hydrogen sulfide concentrations or blood oxygen saturation (P = 0.82). Hydrogen sulfide concentrations increased (P &lt; 0.001) with increasing mDGS inclusion. Blood oxygen saturation was influenced by day of sampling (P = 0.01). Blood oxygen saturation was not affected (P = 0.07) by mDGS inclusion. The fact that ruminal hydrogen sulfide concentrations increased while blood oxygen saturation remained similar raises questions about the quantity of hydrogen sulfide and metabolic fate of excess hydrogen sulfide in the blood of ruminant animals.

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