The Study of Medication Understanding and Medication Adherence in Chinese Patients with Type 2 Diabetes Mellitus

2020 ◽  
Vol 103 (10) ◽  
pp. 1004-1010
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
High Education ◽  
Medication Adherence ◽  
Chinese Patients ◽  
Multiple Logistic Regression ◽  
Low Education

Background: Medication adherence (MA) is a key component to prevent complications of diabetes mellitus. Patients with better medication understanding (MU) showed higher MA. While there were numerous studies of MA in Chinese patients, there has not been any MU study. Objective: To assess the associations of MA and MU in Chinese patients with type 2 diabetes mellitus (T2D). To translate and validate the Chinese version of the Medication Understanding Questionnaire (C-MUQ). Materials and Methods: A cross-sectional study was conducted in 384 Chinese T2D patients. The MA was assessed using the proportion of days covered (PDC), and the MU was assessed using the C-MUQ. The multiple logistic regression was applied to simultaneously assess the association of MA (good or poor MA) with MU and other contributing factors including the sociodemographic characteristics and clinical conditions of patients. Results: The average PDC of study patients was 89.78% (SD 14.75%), and 77.08% of the patients were classified into the good MA group (PDC is 80% or greater). Based on multiple logistic regression as good MA as dependent variable, factors significantly associated with good MA were not long durations of diabetes, not using traditional Chinese medicine (TCM) products, and the interaction effect of high education level and good MU. The adjusted odd ratio (AOR) were 0.28 (95% CI 0.10 to 0.79) for 25 years or more of diabetes durations, 0.33 (95% CI 0.12 to 0.89) for using TCM products, 3.28 (95% CI 1.94 to 8.62) for high education with poor MU, 4.09 (95% CI 1.46 to 7.36) for low education with good MU, and 5.32 (95% CI 2.49 to 11.34) for high education with good MU, respectively. Conclusion: To achieve good MA, the Chinese health professionals should concern about improving MU, especially in the low education patients. Keywords: Medication understanding, Medication adherence, Type 2 diabetes

scholarly journals Medication Adherence Mediates the Association between Type D Personality and High HbA1c Level in Chinese Patients with Type 2 Diabetes Mellitus: A Six-Month Follow-Up Study

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xuemei Li ◽  
Min Gao ◽  
Shengfa Zhang ◽  
Huiwen Xu ◽  
Huixuan Zhou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medication Adherence ◽  
Hba1c Level ◽  
Type D Personality ◽  
Self Report ◽  
Chinese Patients ◽  
Type D

Aims. To examine the association between Type D personality and HbA1c level and to explore the mediating role of medication adherence between them in patients with type 2 diabetes mellitus (T2DM).Methods. 330 patients went on to complete a self-report measure of medication adherence and the HbA1c tests. Chi-square test,Ttest, Ordinary Least Square Regression (OLS), and Recentered Influence Function Regression (RIF) were employed.Results. Patients with Type D personality had significantly higher HbA1c value (P<0.01). When Type D personality was operationalized as a categorical variable, SI was associated with HbA1c (P<0.01). When NA, SI, and their interaction term were entered into regression, all of them were no longer associated with HbA1c level (P>0.1). On the other hand, when Type D personality was operationalized as a continuous variable, only SI trait was associated with HbA1c level (P<0.01). When NA, SI, andNA×SIterm together were entered into regression, only SI was not related to HbA1c level. Furthermore, medication adherence had a significant mediation effect between Type D personality and HbA1c, accounting for 54.43% of the total effect.Conclusion. Type D personality was associated with HbA1c in direct and indirect ways, and medication adherence acted as a mediator role.

Reduced Serum Levels of Brain-Derived Neurotrophic Factor Are Related to Mild Cognitive Impairment in Chinese Patients with Type 2 Diabetes Mellitus

2018 ◽  
Vol 73 (4) ◽  
pp. 271-281 ◽  
Author(s):  
Zhi-chun Sun ◽  
Jing Yu ◽  
Yi-Lan Liu ◽  
Zhen-zhen Hong ◽  
Lin Ling ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Serum Levels ◽  
Chinese Patients ◽  
Diabetic Patients ◽  
Regression Analyses ◽  
Increased Risk

Background: Brain-derived neurotrophic factor (BDNF) is involved in obesity, type 2 diabetes mellitus (T2DM), and cognitive dysfunction. The present study sought to assess the role of serum levels of BDNF in the pathophysiological process of mild cognitive impairment (MCI), a preclinical phase of dementia in 715 Chinese patients with T2DM. Methods: Cross-sectional data were obtained from 715 patients with T2DM recruited from a Chinese diabetes center. Serum levels of BDNF were measured with sandwich enzyme-linked immunosorbent assay. The influence of BDNF on MCI was examined using univariate and multivariate binary logistic regression analyses. Results: In univariate and multivariate logistic regression analyses, for each one-unit increase of BDNF, the unadjusted and adjusted risk of MCI decreased by 9% (OR 0.91; 95% CI 0.88–0.93, p < 0.001) and 6% (0.94; 0.87–0.98, p < 0.001) respectively. In multivariate models comparing the first (Q1), second and third quartiles against the fourth quartile of BDNF, BDNF in Q1 and Q2 were associated with MCI, and increased risk of MCI by 275% (OR 3.75; 95% CI 2.38–6.03) and 155% (2.55; 1.32–4.02). These results suggested that for each 1 ng/mL increase of serum level of BDNF, the association became stronger among obese diabetic patients (OR 0.91, 95% CI 0.85–0.96; p < 0.001) versus nonobese diabetic patients (OR 0.95, 95% CI 0.86–0.98; p = 0.001). Conclusion: The present data demonstrated that reduced serum levels of BDNF were associated with increased risk of MCI and might be useful for identifying diabetic patients at risk of dementia for early prevention strategies.

scholarly journals Effects of FamilyDoctor Concept and Doctor-Patient Interaction Satisfaction on Glycaemic Control among Type 2 Diabetes Mellitus Patients in the Northeast Region of Peninsular Malaysia

2020 ◽  
Vol 17 (5) ◽  
pp. 1765
Author(s):  
Noorfariza Nordin ◽  
Suhaily Mohd Hairon ◽  
Najib Majdi Yaacob ◽  
Anees Abdul Hamid ◽  
Norzaihan Hassan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Glycaemic Control ◽  
Multiple Logistic Regression ◽  
Health Clinics ◽  
Patient Interaction ◽  
The Difference

The implementation of Family Doctor Concept (FDC) to restructure the primary healthcare systems in Malaysia were expected to enhance patient’s satisfaction on doctor-patient interaction and subsequently improved glycaemic control among Type 2 Diabetes Mellitus (T2DM) patients. Thus, this study aims to determine the difference in doctor-patient interaction satisfaction between T2DM patients attended FDC-implemented clinic vs non-FDC clinics, and to determine the association between FDC-implemented clinic and doctor-patient interaction satisfaction towards glycaemic control. A cross-sectional study was conducted throughout 10 districts in Kelantan from February until May 2019 using interview-guided Skala Kepuasan Interaksi Perubatan-11 (SKIP-11) and proforma checklist. Data were analyzed using SPSS ver.24. Chi-square statistic used to determine the difference in doctor-patient interaction satisfaction between both clinics type. Multiple logistic regression used to examine the association between FDC-implemented clinic and doctor-patient interaction satisfaction towards glycaemic control. Twenty primary health clinics involved, and 772 T2DM patients recruited. FDC clinics attendees has higher proportion of satisfaction (40.1%) compared to non-FDC attendees (33.7%) (p = 0.070). Multiple logistic regression confirmed the association of FDC-implemented health clinics (Adj. OR 1.63, p = 0.021), and doctor-patients interaction satisfaction (Adj. OR 1.77, p = 0.005) towards glycaemic control. Hence, strengthening of FDC in primary healthcare and improve the doctor-patient interaction satisfaction were essential to escalate good glycaemic control.

scholarly journals Prevalence and Risk Factors of Latent Tuberculosis Infection (LTBI) in Patients with Type 2 Diabetes Mellitus (T2DM)

2021 ◽  
Vol 18 (1) ◽  
pp. 305
Author(s):  
Phan Ai Ping ◽  
Rosnani Zakaria ◽  
Md Asiful Islam ◽  
Lili Husniati Yaacob ◽  
Rosediani Muhamad ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Logistic Regression ◽  
Smoking Status ◽  
Multiple Logistic Regression ◽  
Cross Sectional ◽  
Significant Difference

Type 2 diabetes mellitus (T2DM) and tuberculosis (TB) together impose a high disease burden in terms of both mortality and health economics worldwide. The objective of this study was to estimate the prevalence and risk factors of latent TB infection (LTBI) in patients with T2DM in Malaysia. A cross-sectional study was performed, and adult T2DM patients (n = 299) were included. Simple and multiple logistic regression analyses were performed to identify the LTBI-associated risk factors in patients with T2DM. Multiple logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CIs) between T2DM and LTBI and was adjusted for potential confounders. The prevalence of LTBI in patients with T2DM was 11.4% (95% CI: 8.0–15.0%). There was no significant difference in the socio-demographic characteristics between LTBI and non-LTBI subjects. No significant difference in the smoking status, the duration of smoking, and the duration of T2DM, HbA1c, or treatments was observed. Interestingly, a higher level of education was observed to be associated with a lower prevalence of LTBI in T2DM patients (aOR: 0.08, 95% CI: 0.01–0.70, p = 0.02). Although the prevalence of LTBI in T2DM was low, it is important to screen for it in T2DM patients due to the risk of developing severe active TB.

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