scholarly journals Membrane Technology in the Production of Immunobiological Preparations Produced by the Branch Office of the FSBE «48 Central Scientific Research Institute» of the Ministry of Defence of Russia (Kirov)

2019 ◽  
Vol 3 (2) ◽  
pp. 137-149
Author(s):  
Leshchenko A.A. , Krupin V.V
Keyword(s):  
Scientific Research ◽  
Scientific Research Institute ◽  
Centrifugal Separation ◽  
Central Scientific Research Institute ◽  
Filtration Method ◽  
Microbial Cells ◽  
Vaccinal Strain ◽  
Branch Office ◽  
Central Scientific ◽  
Research Institute

The researchers of the Branch Office of the Federal State Budgetary Establishment «48 Central Scientific Research Institute» of the Ministry of Defence of the Russian Federation (Kirov) organized theoretical and experimental studies on the introduction of a tangential filtration method for the separation of biological mixtures into the production of immunobiological preparations. The method of microfiltration in the tangential stream replaced the process of sedimentation at the stage of concoction of intermediate vaccines, reduced considerably the process time, and allowed to obtain suspensions from cultural liquid, substandard on an indicator of concentration of microbial cells. Along with this, the microfiltration method allowed to concentrate the cultures of Yersinia pestis of a vaccinal strain EV. In comparison with the centrifugal separation, the concentration of living microbial cells of a vaccinal strain of EV Y. pestis increased by one and a half times. The filtration in a tangential stream at the ASF-020 installation from the point of view of the production of the sporous product of anthrax vaccine STI-1 (in millions of doses), is 1.8 times more effective in comparison with the centrifugal separation. The membrane method allowed to reduce the duration of technological process. These membrane processes are used nowadays during the production of plague and anthrax vaccines, anthrax immunoglobulin, diagnostic medicines and during the sterilization of liquid nutrient mediums. This type of equipment for the sterilization of nutrient mediums can be considered as an alternative to the processes of the thermal sterilization of liquids and provides their biological and technological full functionality. Experiments on the use of the ceramic-metal filters sterilizing the air given for aeration, showed the decrease in duration of preparatory operations on 20 h and increase in the general operational opportunities of the system.

ISSUES OF CONTINUITY OF APPROACHES TO URBAN IMPROVEMENT AND GREENING

2021 ◽  
pp. 5-13
Author(s):  
S.B. Chistyakova ◽  
Keyword(s):  
Urban Planning ◽  
Scientific Research ◽  
Subject Area ◽  
Scientific Research Institute ◽  
Central Scientific Research Institute ◽  
Historical Buildings ◽  
Domestic Science ◽  
Natural Landscapes ◽  
Central Scientific ◽  
Research Institute

The article has been prepared on the basis of many years of research at the Central Scientific Research Institute of Urban Development in the 1970s and 1990s and later works, including those carried out at the Central Scientific Research Institute of Construction of the Ministry of Construction of Russia. The ecological prerequisites of urban planning and the principle of the formation of the natural-ecological frame of the territories of cities as a planning basis for their improvement and landscaping are considered. Taken into account studies of 2019-2020. Since the beginning of the new century, the professional environment has been discussing the negative trends of modern urban planning and urban improvement, accompanied by the loss of their individual appearance. This takes place in the conditions of a market economy and world processes of globalization, which in our subject area are usually called "urbanism". This situation is typical for most cities, and not only for megalopolises, but also for small historical cities. It is shown that excessive unification and depersonalization of the urban environment can be overcome by relying on the fundamental achievements of domestic science and practice. It is also necessary to use systemic, socially oriented and environmentally oriented approaches to the planning and improvement of cities with the formation of interconnected systems of natural and green areas. They should include historical buildings, architectural ensembles and architectural monuments, valuable natural landscapes, historical gardens and parks.

scholarly journals The Results of Monitoring of Deathplaces of Animals, Died from Anthrax during the Epizootic 2016 in Yamal-Nenets Autonomous District

2017 ◽  
Vol 1 (3) ◽  
pp. 18-29
Keyword(s):  
Scientific Research ◽  
Scientific Research Institute ◽  
Common Source ◽  
Central Scientific Research Institute ◽  
Autonomous District ◽  
Microbial Cultures ◽  
Two Samples ◽  
Nenets Autonomous ◽  
Central Scientific ◽  
Research Institute

The article presents the results of the study of samples taken in 2017 by the specialists from the «48 Central Scientific Research Institute» of the Ministry of Defence of Russia in the course of the survey of deathplaces of animals in the territories of Yamal region of the Yamal-Nenets Autonomous District, contaminated by the Bacillus anthracis agent. Thirty two samples have been taken during the survey. Real-time PCR identified specific fragments of B. anthracis DNA in two of them – in the ash, taken at the spot of the cremation of the reindeer`s corpse and in the biological material from one of the unburned corpses. Pure microbial cultures of B. anthracis agent have been obtained from these samples. They all possessed the biological properties, typical for high virulent B. anthracis strains. The lethal dose (LD 50 ) for white mice turned out to be 5.8 and 6.2 spores for No 3 and No 13 isolates consequently, and the average lifetime of animals since the moment of contamination till death did not exceed 3.5 days. The genetic typing of the isolated isolates for 18 VNTR-loci of the chromosomal localization showed that their genotypes were identic to the B. anthracis strain Yamal-1, obtained by the experts from the branch offfice of the «48 Central Scientific Research Institute» of the Ministry of Defence of Russia (Kirov) from the corpse of a reindeer during the liquidation of the anthrax epizootic in the Yamal-Nenets Autonomous District in summer 2016. The coincidence of the genetic profiles of the isolated microbial cultures and B. anthracis strain Yamal-1 indicated one common source of their origin and the presence of the stable focus of B. anthracis at the territory of Yamal District. This fact needs more attention from local authorities and requires concerted attention to the epizootic and epidemiological situation in the region.

Central Scientific Research Institute for Geological

1974 ◽  
Vol 16 (6) ◽  
pp. 665-673 ◽  
Author(s):  
M.B. Borodayevskaya ◽  
N.K. Kurbanov ◽  
A.I. Krivtsov ◽  
A.D. Rakcheyev
Keyword(s):  
Scientific Research ◽  
Scientific Research Institute ◽  
Central Scientific Research Institute ◽  
Central Scientific ◽  
Research Institute

scholarly journals Participation of Scientific Research Organizations of the Russian NBC Protection Troops in Ensuring Epidemiological and Epizootic Well-Being of the Yamal-Nenets Autonomous District during the Anthrax Epizootic Outbreak in 2016–2018

2020 ◽  
Vol 4 (2) ◽  
pp. 168-176
Keyword(s):  
Scientific Research ◽  
Well Being ◽  
Scientific Research Institute ◽  
Central Scientific Research Institute ◽  
Autonomous District ◽  
Research Organizations ◽  
Research Organisations ◽  
Nenets Autonomous ◽  
Central Scientific ◽  
Research Institute

2016 was marked by the largest epizootic of anthrax among reindeer and people in the Yamal-Nenets Autonomous District. The development of the emergency situation has led to significant economic and material losses to the region. The federal executive bodies, as well as scientific research organisations of the Russian NBC Protection Troops were attracted to the elimination of consequences of this epizootic. The aim of this work was to summarize the role of scientific research organizations of the Russian NBC Protection Troops in ensuring epidemiological and epizootic well-being of the Yamal-Nenets Autonomous District during the anthrax epizootic outbreak in 2016–2018. The experts from the «48 Central Scientific Research Institute» of the Ministry of Defence together with the experts from the territorial branches of Federal Service for Veterinary and Phytosanitary Surveillance, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing and executive bodies of the Yamal-Nenets Autonomous District have developed a «Comprehensive Anthrax Prevention Plan for the Territory of the Yamal-Nenets Autonomous District for 2017–2020». This plan was dedicated to the monitoring and analyzing the epizootic situation, to the movement control, to the vaccination of people at risk and animals, as well as to the systematic control of epidemiological and epizootic well-being (sampling). Due to the implementation of these measures, an anthrax outbreak in Yamal was localized in autumn 2018. In order to monitor the situation at the sites of the epizootic in 2016, the specialists from the scientific research organisations of the Russian NBC Protection Troops carried out the selection and delivery of biological samples to the laboratory base of the «48 Central Scientific Research Institute» of the Ministry of Defence of Russia for their in-depth study. The results of VNTR typing allowed to state, that the genotype of Bacillus аnthracis isolates, that caused the anthrax epizootic outbreak in the Yamal, was not exotic for Russia. The genetic material of B. anthracis, analysed by the experts from the branch office of the «48 Central Scientific Research Institute», showed that it was identical with the B. anthracis strain genotype, obtained in 2016 in the Yamal-Nenets Autonomous District

An Anti-collision Indicator

1968 ◽  
Vol 21 (2) ◽  
pp. 163-170 ◽  
Author(s):  
O. Mitrofanov
Keyword(s):  
Soviet Union ◽  
Collision Avoidance ◽  
Water Transport ◽  
Black Sea ◽  
Scientific Research ◽  
Scientific Research Institute ◽  
The Black Sea ◽  
Central Scientific Research Institute ◽  
The Soviet Union ◽  
Central Scientific

The problem of collision-avoidance at sea by means of radar is constantly under discussion in maritime circles within the U.S.S.R. This paper, and that of Captain Bukhanovski (Journal, 20, 247,), describe one direction of research that has been actively pursued in the Soviet Union.The device described was developed by the Central Scientific Research Institute for Water Transport for the Ministry of Merchant Marine and sea trials were carried out in the Black Sea during the summer of 1962. The present paper describes the principles of the device and the performance during trials. It has been prepared for publication in the Journal in collaboration with Captain G. Shoomayko.Articles on the prototype have appeared in Morskoi Flot (no. 122, 1959, no. 2, 1964), Die Seewarte (Hamburg, October 1961) and Navigation (Paris, July 1962).

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