Glycemic index of nuggets made from eel flour (Monopterus albus) and tempeh flour for nutritional support for diabetic hemodialysis patients

Background: Diabetes mellitus is one of the cause of end-stage renal failure and is also a comorbid of end-stage renal failure patient with hemodialysis. Diabetes is difficult to treat in diabetic hemodialysis patients. Diabetic hemodialysis patients will also experience malnutrition because of inadequate protein intake and gastrointestinal disorders such as nausea, vomiting, and anorexia, so nutritional support that meets the requirements of the diabetic hemodialysis diet is needed, which is high in protein, high in calcium, low in phosphorus, and has a low glycemic index, completed by nuggets made from a mixture of eel flour and tempeh flour. Objective: To determine the quantity and glycemic index category of nuggets made from a mixture of eel flour and tempeh flour with a proportion of 50%: 50% as nutritional support for diabetic hemodialysis patients. Methods: This experimental study using the one group intervention without control design used objects in the form of nuggets with the proportion of mixing eel flour (Monopterus albus) and tempeh flour by 50%: 50%. The measurement of glycemic index was carried out after respondents consumed test food (nuggets). Blood glucose levels measurement conducted at 30th minute, 60th minute, 90th minute, and 120th minute respectively. Results: The nugget’s glycemic index was 48.06, so it was categorized as a low glycemic index. Conclusion: Nugget made from eel flour and tempeh flour with a proportion of 50%: 50% is categorized as a food with low glycemic index, and it can be given as nutritional support for diabetic hemodialysis patients.

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Accumulation of albumin-linked and free-form pentosidine in the circulation of uremic patients with end-stage renal failure: renal implications in the pathophysiology of pentosidine.

Journal of the American Society of Nephrology ◽

10.1681/asn.v781198 ◽

1996 ◽

Vol 7 (8) ◽

pp. 1198-1206 ◽

Cited By ~ 2

Author(s):

T Miyata ◽

Y Ueda ◽

T Shinzato ◽

Y Iida ◽

S Tanaka ◽

...

Keyword(s):

Renal Failure ◽

Renal Function ◽

Gel Filtration ◽

Kinetic Studies ◽

Hemodialysis Patients ◽

Free Form ◽

Diabetic Patients ◽

Glucose Levels ◽

Uremic Patients ◽

End Stage

Pentosidine is an advanced glycation end product and its formation is shown to be closely related to oxidative processes. Recent studies have shown that pentosidine levels are increased not only in plasma and matrix proteins from diabetic patients, but also markedly in nondiabetic hemodialysis patients. Currently, the mechanism of accumulation and kinetics of pentosidine formation in hemodialysis patients remain unknown. Gel filtration of uremic plasma revealed that plasma pentosidine exists in the albumin fraction (approximately 90%) and, interestingly, in free form (approximately 5%) as well. Plasma free pentosidine was undetectable in subjects with normal renal function. There was a significant correlation between the plasma levels of albumin-linked and free pentosidine in hemodialysis patients. Kinetic studies indicated that dietary pentosidine was absorbed into the circulation and that, after either oral or intravenous administration of pentosidine to intact or nephrectomized rats, the plasma free pentosidine level was closely linked to the level of renal function. These findings demonstrate that: (1) Pentosidine accumulates as albumin-linked and in free form in the circulation of uremic patients; (2) dietary pentosidine can be absorbed into the circulation, thus being one possible origin of circulating free pentosidine; (3) free pentosidine may accumulate as a result of decreased glomerular filtration; and (4) the mechanism of accumulation of albumin-linked pentosidine is not related to high glucose levels. It suggests the simultaneous accumulation, during renal failure, of either unknown pentosidine precursor(s) or catalyst(s) of glycoxidation, independent of glucose.

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COMPARISON OF OBESITY DIAGNOSTIC METHODS IN CHRONIC HEMODIALYSIS PATIENTS

Natural resources of the Earth and environmental protection ◽

10.26787/nydha-2713-203x-2021-2-1-60-65 ◽

2021 ◽

Vol 2 (1) ◽

pp. 60-65

Author(s):

Filinjuk P.Ju.

Keyword(s):

Renal Failure ◽

Sensitivity And Specificity ◽

Hemodialysis Patients ◽

Chronic Hemodialysis ◽

Diagnostic Methods ◽

Dialysis Patients ◽

End Stage Renal Failure ◽

Treat Ment ◽

End Stage ◽

Bioimpedance Measurement

The article deals with the problem of diagnosing obesity in patients with end-stage renal failure receiving treat-ment with programmed hemodialysis. The aim of the work was to study the indicators of the information content of various methods for diagnosing obesity among dialysis patients. The objective of the study was to compare the sensitivity and specificity of such methods for diagnosing obesity as BMI, OT / OB index, BAI, electronic caliperom-etry, bioimpedance measurement. The possibility of prac-tical application of the study is to optimize the approach to methods of diagnosing obesity in dialysis patients.

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DOMINAN FACTORS RELATED TO QUALITY OF LIFE OF PATIENTS WITH END STAGE RENAL FAILURE UNDERGOING HEMODIALYSIS AT TABANAN GENERAL HOSPITAL

Jurnal Riset Kesehatan Nasional ◽

10.37294/jrkn.v2i2.120 ◽

2018 ◽

Vol 2 (2) ◽

pp. 195

Author(s):

Anselmus Aristo Parut ◽

I Gusti Ayu Puja Astuti Dewi

Keyword(s):

Quality Of Life ◽

Renal Failure ◽

General Hospital ◽

Hemodialysis Patients ◽

The Body ◽

Dominant Factor ◽

Life Questionnaire ◽

End Stage Renal Failure ◽

End Stage

Background : Renal failure is a clinical condition which irreversible reduction in renal function and need hemodialysis as replacement for kidney function. Hemodialysis is a dialysis that perform outsite the body. Indonesian Association Of Nephrology (Pernerfi) stated that new hemodialysis and active hemodialysis patients in Indonesia since 2007-2018 increased, 14.644 new hemodialysis patients and 7.276 active hemodialysis patients.Method : This is a descriptive analysis study with cross-sectional design and multiple logistic regression to identify dominant factor related to quality of life hemodialysis patients. Location of this research was Tabanan General Hospital. The sampling technique was nonprability sampling with total population were 166 patients. Data collected using insomnia questionnaire, family support questionnaire, quality if life questionnaire and complication observation form. Result : The result showed that, higher OR found in intra hemodialysis variabel (OR:180,917), which mean that intra hemodialysis complication is a dominan factor related to quality of life hemodialysis patients. Patients who had complication were more likely to have low quality of life. Further study are needed to identify factors related to intra hemodialysis complications. Keywords : Dominan factors, intra hemodialysis complications, quality if life, end stage renal failure, hemodialysis.

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Pharmacokinetics of Recombinant Hirudin in Hemodialyzed End-stage Renal Failure Patients

Thrombosis and Haemostasis ◽

10.1055/s-0038-1656028 ◽

1997 ◽

Vol 77 (04) ◽

pp. 650-655 ◽

Cited By ~ 67

Author(s):

R Vanholder ◽

A Camez ◽

N Veys ◽

A Van Loo ◽

A M Dhondt ◽

...

Keyword(s):

Renal Failure ◽

Renal Function ◽

Residual Renal Function ◽

Hemodialysis Patients ◽

The Body ◽

Pharmacokinetic Data ◽

High Flux ◽

Recombinant Hirudin ◽

End Stage Renal Failure ◽

End Stage

SummaryRecently, hirudin was used for the first time as an anticoagulant during hemodialysis in men. Pharmacokinetic data of this compound in end-stage renal failure are however not available. In this study, the pharmacokinetics of recombinant hirudin (HBW 023) was evaluated in hemodialysis-treated end-stage renal failure patients. HBW 023 was administered as a bolus at the start of a single dialysis (0.02 to 0.08 mg/kg) in 20 patients, and plasma hirudin levels were followed during this and the 5 following dialyses, without additional hirudin administration. The initial dialysis (HDj) was performed with a low flux polysulfone dialyzer; the following dialyses (up to HD6) with a high flux polysulfone dialyzer and regular heparin. Hirudin levels averaged 504.0 ± 214.0 and 527.7 ± 217.1 ng/ml in the middle and at the end of HDj, and then gradually decreased to 15.2 ± 15.2 ng/ml at the end of HD6. Pharmacokinetic data were compared to those obtained in healthy controls (n = 5), receiving the same dose, and reaching the same peak hirudin level. Hirudin half-life was >30 times longer in hemodialysis patients (51.8 ± 15.6 vs. 1.7 ± 1.5 h, p <0.001), whereas area under the curve was >60 times higher (34,669 ± 14,898 vs. 545 ± 205 ng/ml X h, p <0.001). Distribution volume was lower in hemodialysis patients (11.0 ± 3.1 vs. 14.1 ± 2.0 1, p <0.05). Hirudin disappearance rate was the same during high flux polysulfone dialysis as during interdialytic periods. Hirudin removal was markedly higher in those patients still maintaining some residual renal function and parameters of hirudin removal were significantly correlated to residual creatinine clearance. It is concluded that hirudin removal from the body is markedly depressed in hemodialyzed end-stage renal failure patients and that even minor residual renal function may increase this removal rate.

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