scholarly journals Hubungan Usia Kehamilan dengan Kejadian Meconium Aspirasi Syndrom

2021 ◽  
Vol 11 (1) ◽  
pp. 11-23
Author(s):  
Ratna Wahyu Rini ◽  
Inayatul Aini ◽  
Ratna Sari Dewi
Keyword(s):  
Meconium Aspiration Syndrome ◽  
Chi Square ◽  
Meconium Aspiration

Umur kehamilan ibu umumnya berlangsung 40 minggu atau 280 hari. Meconium Aspiration Syndrome (MAS) adalah sindrom atau kumpulanberbagai gejala klinis dan radiologis akibat janin atauneonatus menghirup atau mengaspirasi mekonium.Penelitian ini untuk mengetahui hubungan usia kehamilan dengan kejadian meconium aspirasi syndrom di Puskesmas Nglumber Kecamatan Kepoh Baru Kabupaten Bojonegoro. Desain penelitian yang digunakan adalah analitik korelasional dengan pendekatan retrospectif. Populasi ibu bersalin sebanyak 24 orang.Sampel penelitian ini berjumlah 24 responden. Sampling yang digunakan dalam penelitian ini menggunakan cara tehnik total sampling, variabel independennya umur kehamilan dan variabel dependentnya kejadian meconium aspirasi syndrom, untuk mengetahui hubungan antara variabel digunakan uji korelasi Chi-Square dengan instrumen menggunakan rekam medik. Dari hasil penelitian lebih dari setengah responden dengan kehamilan aterm sebanyak 14 responden (58,3%), , hampir setengah responden dengan kehamilan postterm sebanyak 7 responden (29,2%) dan sebagian kecil responden dengan kehamilan preterm sebanyak 3 responden (12,5%). Dan lebih dari setengah responden tidak mengalami meconium aspirasi syndrom sebanyak 17 responden (70,8%) dan dan hampir setengah mengalami meconium aspirasi syndrom sebanyak 7responden (29,2%). Dari analisa statistik dengan menggunakan uji statistik Chi-Square sebesar 0.000, dengan peluang ralat kesalahan sebesar 0.000 dimana ρ < α (0.05). Dari hasil penelitian dapat disimpulkan bahwa terdapat hubungan usia kehamilan dengan kejadian meconium aspirasi syndrom. Upaya yang dilakukan untuk mengatasi masalah yaitu perlu upaya penanganan yang tepat pada ibu hamil dengan usia kehamilan postterm sehingga nantinya bayi yang dilahirkan ibu tidak mengalami MAS

scholarly journals Associations of viscosity, stercobilin and bilirubin levels in meconium stained amniotic fluid to meconium aspiration syndrome

2011 ◽  
Vol 51 (2) ◽  
pp. 101
Author(s):  
M. Sholeh Kosim ◽  
Lisyani B. Suromo ◽  
Chrisna Hendarwati
Keyword(s):  
Amniotic Fluid ◽  
Meconium Aspiration Syndrome ◽  
Chi Square ◽  
Meconium Aspiration ◽  
Exact Test ◽  
Kappa Test ◽  
Chi Square Test ◽  
Observational Cohort ◽  
Meconium Stained Amniotic Fluid

Background Meconium-stained amniotic fluid (MSAF) increases morbidity and mortality in neonates. Meconium aspiration syndrome (MAS) occurs in 2-9% of neonates with MSAF. Viscosity of MSAF is associated with the amount of the meconium release.Objective To determine the associations between viscosity and the presence of stercobilin and bilirubin in MSAF with MAS in neonates.Methods This observational cohort study was perfonned with term babies who were born v.ith MSAF in Kariadi Hospital from August 2009 to May 2010. Amniotic fluid specimens were taken at birth and neonates were observed for respiratory symptoms until the 5th day of life. Analysis was done by chi-square test, Fisher's exact test and relative risk.Results The majority of the 48 subjects were male, Mth mean gestational age of 39.9 (SD 1.73) weeks. Classification of MSAF as thick or thin was done by macroscopic examination Mth Kappa test 0.741. The MSAF tested ositively for stercobilin and bilirubin in 12/48 and 17/48 subjects, respectively. Thick MSAF correlated significantly to MAS (P=0.03) Mth a relative risk of 10.1 (95% CI 1.2 to 87 .6), while stercobilin and bilirubin presence did not.Conclusion Thick MSAF was associated Mth lvtAS and was a risk factor for MAS. Stercobilin and bilirubin presence in MSAF were not associated with MAS.

scholarly journals Meconium aspiration syndrome and neonatal outcome: a hospital based study

2019 ◽  
Vol 6 (3) ◽  
pp. 1330
Author(s):  
Siva Saranappa S. B. ◽  
Shiva Devaraj ◽  
Nithya E.
Keyword(s):  
Amniotic Fluid ◽  
Perinatal Asphyxia ◽  
Meconium Aspiration Syndrome ◽  
Assisted Ventilation ◽  
P Value ◽  
Special Focus ◽  
Chi Square ◽  
Meconium Aspiration ◽  
Chi Square Test ◽  
Meconium Stained Amniotic Fluid

Background: The incidence of meconium stained amniotic fluid is 8-20% among all deliveries. The Aspiration of meconium into the airway results in various short term and long term morbidities and mortality. Timely management of these neonates with meconium in amniotic fluid may prevent Meconium aspiration syndrome.Methods: This prospective cohort study was conducted at Kempegowda Institute of Medical Sciences, Bangalore. All live Term neonates born between December 2016 and July 2018 with meconium in amniotic fluid were enrolled in the study. Details of the neonate was entered in the pre-designed Proforma. The objective of this study the outcome of MAS neonates and find factors associated with Meconium aspiration syndrome when compared with Meconium stained amniotic fluid neonates as a whole. These associated factors were presented as Odds Ratio (OR) and 95% Confidence Interval. Chi-square test was done where applicable and a p-value <0.05 was taken as significant.Results: Meconium aspiration syndrome was seen in 79 out of the 188 neonates born with meconium stained amniotic fluid.Conclusions: The morbidity and mortality in a neonate with Meconium stained amniotic fluid (MSAF) to develop meconium aspiration syndrome (MAS) can be avoided with timely antenatal care. Meconium-stained babies should be aggressively managed to prevent complications like perinatal asphyxia and respiratory failure which may lead to the mortality. Those neonates with risk for adverse outcome should be managed with special focus on respiratory care with use of assisted ventilation and inhaled nitric oxide and extracorporeal membrane oxygenation, where available.

scholarly journals Randomized Trial of Oxygen Saturation Targets during and after Resuscitation and Reversal of Ductal Flow in an Ovine Model of Meconium Aspiration and Pulmonary Hypertension

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 594
Author(s):  
Amy L. Lesneski ◽  
Payam Vali ◽  
Morgan E. Hardie ◽  
Satyan Lakshminrusimha ◽  
Deepika Sankaran
Keyword(s):  
Blood Flow ◽  
Pulmonary Hypertension ◽  
Oxygen Saturation ◽  
Ductus Arteriosus ◽  
Neonatal Resuscitation ◽  
Meconium Aspiration Syndrome ◽  
Ovine Model ◽  
Neurodevelopmental Outcomes ◽  
Meconium Aspiration ◽  
Blood Flows

Neonatal resuscitation (NRP) guidelines suggest targeting 85–95% preductal SpO2 by 10 min after birth. Optimal oxygen saturation (SpO2) targets during resuscitation and in the post-resuscitation management of neonatal meconium aspiration syndrome (MAS) with persistent pulmonary hypertension (PPHN) remains uncertain. Our objective was to compare the time to reversal of ductal flow from fetal pattern (right-to-left), to left-to-right, and to evaluate pulmonary (QPA), carotid (QCA)and ductal (QDA) blood flows between standard (85–94%) and high (95–99%) SpO2 targets during and after resuscitation. Twelve lambs asphyxiated by endotracheal meconium instillation and cord occlusion to induce MAS and PPHN were resuscitated per NRP guidelines and were randomized to either standard (85–94%) or high (95–99%) SpO2 targets. Out of twelve lambs with MAS and PPHN, six each were randomized to standard and high SpO2 targets. Median [interquartile range] time to change in direction of blood flow across the ductus arteriosus from right-to-left, to left-to-right was significantly shorter with high SpO2 target (7.4 (4.4–10.8) min) compared to standard SpO2 target (31.5 (21–66.2) min, p = 0.03). QPA was significantly higher during the first 10 min after birth with higher SpO2 target. At 60 min after birth, the QPA, QCA and QDA were not different between the groups. To conclude, targeting SpO2 of 95–99% during and after resuscitation may hasten reversal of ductal flow in lambs with MAS and PPHN and transiently increase QPA but no differences were observed at 60 min. Clinical studies comparing low and high SpO2 targets assessing hemodynamics and neurodevelopmental outcomes are warranted.

Value of Amnioinfusion in Reducing Meconium Aspiration Syndrome

1993 ◽  
Vol 10 (01) ◽  
pp. 43-45 ◽  
Author(s):  
Michael Uhing ◽  
Rama Bhat ◽  
Medhat Philobos ◽  
Tonse Raju
Keyword(s):  
Meconium Aspiration Syndrome ◽  
Meconium Aspiration

Surfactant Therapy in Full-term Neonates With Severe Respiratory Failure

PEDIATRICS ◽  
1993 ◽  
Vol 92 (1) ◽  
pp. 135-139
Author(s):  
Hatem Khammash ◽  
Max Perlman ◽  
Julian Wojtulewicz ◽  
Michael Dunn
Keyword(s):  
Respiratory Failure ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Oxygenation Index ◽  
Meconium Aspiration Syndrome ◽  
Full Term ◽  
Surfactant Therapy ◽  
Term Infants ◽  
Meconium Aspiration

Objective. In light of the paucity of published data on the use of surfactant in full-term infants with respiratory failure due to meconium aspiration syndrome and respiratory distress syndrome, we report our experience with this therapy. Our goal was to explore possible justification for randomized controlled trials of surfactant treatment in similar patients at an earlier, less severe stage of the disease. Methods. Retrospective consecutive case series of 20 infants with severe meconium aspiration syndrome and 29 infants with severe respiratory distress syndrome who received bovine surfactant between March 1990 and December 1992 in three neonatal intensive care units in a regionalized setting. Outcome of treatment was assessed by comparing changes in several respiratory indices including the oxygenation index, between 4 and 6 hours and 1 and 3 hours before and after the first dose of surfactant. Differences were analyzed using analysis of variance for repeated measures, with treatment and time as co-variates. Results. In the meconium aspiration group the mean oxygenation index decreased from 36 ± 12 at 1 to 3 hours presurfactant to 24 ± 14 at 1 to 3 hours postsurfactant (P &lt; .001). In the patients with respiratory distress syndrome the mean oxygenation index fell from 30 ± 17 at 1 to 3 hours presurfactant to 12 ± 6 at 1 to 3 hours postsurfactant (P = .0001). Three of 20 patients with meconium aspiration syndrome and 3 of 29 patients with respiratory distress syndrome received extracorporeal membrane oxygenation. Conclusions. Surfactant therapy in full-term infants with respiratory failure due to the meconium aspiration and respiratory distress syndromes is often effective in improving gas exchange. A randomized controlled trial of surfactant therapy at an earlier stage in the course of the illness should be performed.

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