scholarly journals Isolation and Characterization of PHA Producing Bacteria from Sewage Samples of Assam

2019 ◽  
Vol 8 (4) ◽  
pp. 10686-10692
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Bacterial Species ◽  
Scale Production ◽  
High Turnover ◽  
Isolation And Characterization ◽  
Naturally Occurring ◽  
Large Scale Production ◽  
The Individual

Polyhydroxyalkanoate (Pha) Is A Family Of Naturally Occurring Polymers Which Is Reportedly Produced By More Than 75 Genera Of Gram-Positive And Gram-Negative Bacteria. Although The Industrial Production Of This Bioplastic Commenced Decades Ago, Its Large Scale Production Is Still Debilitated By Factors Such As Rate Of Production By The Bacteria And The Raw Materials For Its Production, Which Finally Elevates The Production Cost. The Present Thrust In This Area Is To Isolate Bacterial Species Which Have A High Turnover Of Pha With Minor Expenditure. Sewage And Sewage Sludge Samples Are Rich Sources Of Microflora Which Offer A Nutrient Limited Habitat To The Individual Organisms. Under These Conditions Of Stress, Native Organisms Develop A Metabolomics Which Efficiently Convert Vital Nutrients Into Essential Macromolecules, And In This Case A Storage Polymer Of Industrial Significance I.E. Pha. In This Pilot Study An Attempt Was Made To Isolate Indigenous Bacterial With Ability To Produce The Polymer.

scholarly journals Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

2011 ◽  
Vol 55 (5) ◽  
pp. 1975-1981 ◽  
Author(s):  
Matthew A. Gregory ◽  
Michael Bobardt ◽  
Susan Obeid ◽  
Udayan Chatterji ◽  
Nigel J. Coates ◽  
...  
Keyword(s):  
Large Scale ◽  
Scale Production ◽  
Subgenomic Replicon ◽  
Isomerase Activity ◽  
Lead Compounds ◽  
Naturally Occurring ◽  
Large Scale Production ◽  
Pharmacokinetic Properties ◽  
Biosynthetic Engineering

ABSTRACTCyclophilin inhibitors currently in clinical trials for hepatitis C virus (HCV) are all analogues of cyclosporine (CsA). Sanglifehrins are a group of naturally occurring cyclophilin binding polyketides that are structurally distinct from the cyclosporines and are produced by a microorganism amenable to biosynthetic engineering for lead optimization and large-scale production by fermentation. Preclinical characterization of the potential utility of this class of compounds for the treatment of HCV revealed that the natural sanglifehrins A to D are all more potent than CsA at disrupting formation of the NS5A-CypA, -CypB, and -CypD complexes and at inhibition of CypA, CypB, and CypD isomerase activity. In particular, sanglifehrin B (SfB) was 30- to 50-fold more potent at inhibiting the isomerase activity of all Cyps tested than CsA and was also shown to be a more potent inhibitor of the 1b subgenomic replicon (50% effective concentrations [EC50s] of 0.070 μM and 0.16 μM in Huh 5-2 and Huh 9-13 cells, respectively). Physicochemical and mouse pharmacokinetic analyses revealed low oral bioavailability (F< 4%) and low solubility (<25 μM), although the half-lives (t1/2) of SfA and SfB in mouse blood after intravenous (i.v.) dosing were long (t1/2> 5 h). These data demonstrate that naturally occurring sanglifehrins are suitable lead compounds for the development of novel analogues that are less immunosuppressive and that have improved metabolism and pharmacokinetic properties.

scholarly journals Large-scale production and physicochemical characterization of human immune interferon.

1979 ◽  
Vol 26 (1) ◽  
pp. 36-41 ◽  
Author(s):  
M P Langford ◽  
J A Georgiades ◽  
G J Stanton ◽  
F Dianzani ◽  
H M Johnson
Keyword(s):  
Large Scale ◽  
Physicochemical Characterization ◽  
Scale Production ◽  
Immune Interferon ◽  
Large Scale Production ◽  
Human Immune

An Improved And Suitable Method For Large Scale Produdcion Of Α-Monochlorocyclodecanone

2021 ◽  
Vol 18 ◽  
Author(s):  
Wenhua Ou ◽  
Ruolin Wang ◽  
Ruonan Liu ◽  
Hong Huang
Keyword(s):  
Silica Gel ◽  
Large Scale ◽  
Raw Materials ◽  
Separation Method ◽  
Suitable Method ◽  
Scale Production ◽  
Reaction Conditions ◽  
Environment Friendly ◽  
Large Scale Production ◽  
Ideal Approach

: α-Monochlorocyclododecanone was synthesized from cyclododecane and 1,3-Dichloro-5,5-dimethylhydantoin (DCDMH) catalyzed with silica gel in MeOH. The product was obtained by crystallization with nearly 85% yield. The presented method used cheap raw materials, mild reaction conditions, simple separation method and environment-friendly process. Additionally, the current synthesis provided an ideal approach for large-scale production.

Strength and Impotence. The Developing Countries and the Development in New Territories

1974 ◽  
Vol 9 (2-3) ◽  
pp. 167-177
Author(s):  
Willy Østreng
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Developed Countries ◽  
Economic Effects ◽  
Scale Production ◽  
Underdeveloped Countries ◽  
The North ◽  
Large Scale Production ◽  
The Developed Countries ◽  
The Third World

This article examines the possible political and economic effects of large-scale mineral extraction from the seabed. The findings presented indicate that development in new territories may conceivably serve to exacerbate existing conflict dimensions, notably the North/South dimension in global politics. Because of the developed countries' monopoly on know-how and economic capability, exploration and exploitation of the inorganic resources of the ocean floor has de facto been the exclusive domain of these countries. On the basis of this the author shows that if large-scale production of seabed resources should become a reality in the near future, the underdeveloped countries will be forced to watch it from the sidelines. As a consequence, the exploitation of offshore raw materials will probably contribute to the further widening of the gap between developed and underdeveloped countries. Further commenting on the fact that the latter today are the main producers of the most promising seabed resources, the author expresses the view that exploitation will have a detrimental effect on the economics of the Third World countries, since it might lead to overproduction and price reductions.

The Origin of Puuc Slate Ware: New Data from Sayil, Yucatan, Mexico

1995 ◽  
Vol 6 ◽  
pp. 119-134 ◽  
Author(s):  
Michael P. Smyth ◽  
Christopher D. Dore ◽  
Hector Neff ◽  
Michael D. Glascock
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Compositional Analysis ◽  
Classic Period ◽  
Scale Production ◽  
Local Production ◽  
Comprehensive Investigation ◽  
Terminal Classic ◽  
Large Scale Production ◽  
Major Producer

AbstractThis paper reports results of the first neutron-activation analysis (NAA) of ancient pottery wares and clays from the Puuc region of Yucatan. Based on ceramics from Sayil, this investigation seeks to expand exploration into the nature of commercialization during the Terminal Classic period (A.D. 800–1000). This research sought to: (a) establish the chemical composition of major Puuc wares, (b) begin to define potential raw materials and production loci at Sayil, and (c) explore the question of whether Sayil was a major producer and exporter of ceramic wares. Compositional analysis reveals that three of the four major Puuc wares (Puuc Slate, Puuc Unslipped, and Puuc Red) exhibit some degree of chemical distinctiveness, suggesting discrete production units. Compositional analysis of clays from Sayil and Loltun Cave indicates that Puuc Slate and Puuc Red Ware are compatible with clays locally available at Sayil, supporting local production of these wares, whereas Puuc Unslipped Ware initially appears to be closer compositionally to clays from Loltun. In addition, Puuc Slate is an important ware found throughout northern Yucatan that shows evidence of large-scale production at Sayil. This analysis represents the first steps of a comprehensive investigation into the Maya economy of Terminal Classic Yucatan.

scholarly journals Biosurfactants – Nature's Solution for Today's Cleaning Challenges

2021 ◽  
Vol 75 (9) ◽  
pp. 752-756
Author(s):  
Jakob J. Mueller ◽  
Hans H. Wenk
Keyword(s):  
Large Scale ◽  
Raw Materials ◽  
Biological Molecules ◽  
Raw Material ◽  
Scale Production ◽  
Sustainable Solutions ◽  
Natural Substances ◽  
Head Groups ◽  
Large Scale Production ◽  
Recent Developments

Biosurfactants are surface-active molecules, developed by nature through evolution and naturally produced by different microorganisms. The most prominent examples are rhamnolipids and sophorolipids, molecules which contain hydrophilic sugar head groups and hydrophobic alkyl residues leading to an amphiphilic behavior with unique properties. Recent developments in the field of biotechnology enable the large-scale production of these biological molecules. The raw material basis is 100% renewable since sugars and oils are used as major raw materials. Additionally, biosurfactants are fully biodegradable, which allows the path back into the natural cycles. In comparison to established standard surfactants like SLES/SLS (sodium laureth (ether) sulfates) or betaines, rhamnolipids are much milder and, at the same time, show similar or even better performance in household or personal care applications. Foam behavior, solubilization and cleaning effectiveness are examples where these natural substances give excellent results compared to the synthetic benchmarks. The commercialization of biosurfactants at industrial scale now offers alternatives to consumers seeking sustainable solutions, without compromising performance. Biosurfactants combine both and set a new standard for surfactant applications.

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