scholarly journals PASTILIŲ SU SAUSUOJU MELISŲ EKSTRAKTU MODELIAVIMAS IR KOKYBĖS VERTINIMAS

2021 ◽  
Vol 31 (7) ◽  
pp. 41-44
Author(s):  
Kristina Perminaitė ◽  
Saimonas Marcinkus ◽  
Aurimas Galkontas
Keyword(s):  
Melissa Officinalis

Natūralūs augaliniai ekstraktai vertinami dėl savo gydomųjų savybių visame pasaulyje. Vaistinės melisos (Melissa officinalis L.) ekstraktas pasižymi farmakologinio poveikio įvairove – uždegimo slopinamuoju, raminamuoju, antioksidaciniu. Aktualu pagaminti kietas farmacines formas – pastiles su sausuoju melisos ekstraktu, kurios užtikrintų vartotojams tinkamą naudojimą, nes pastilės pasižymi maloniu skoniu, o panaudojus pagalbines medžiagas, galima kokybiškai įterpti ekstraktą ir tinkamai ištirpinti veikliąsias medžiagas. Tyrimo tikslas – sumodeliuoti ir pagaminti pastiles su sausuoju melisos ekstraktu ir įvertinti jų kokybę. Buvo pagamintos 3 skirtingos pastilių serijos, naudojant skirtingas pagalbines medžiagas. Sumodeliuotos ir pagamintos pastilės su želatina, su kakava ir kakavos sviestu, su medumi. Įvertintos pagamintų pastilių masės vienodumo, išvaizdos vienodumo, skoninės ir juslinės savybės, atlikti pastilių suirimo ir tirpimo testai. Tirpimo testo in vitro metu buvo matuojamas bendrasis atsipalaidavęs fenolinių junginių bei galo rūgšties kiekis. Tyrimo rezultatai parodė, kad pagamintos pastilės buvo tolygios masės, tinkamos išvaizdos, o naudojamos pagalbinės medžiagos turi įtakos fenolinių junginių ir galo rūgšties atsipalaidavimui in vitro.

scholarly journals Chemical Composition, In Vitro and In Silico Antioxidant Potential of Melissa officinalis subsp. officinalis Essential Oil

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1081
Author(s):  
Matilda Rădulescu ◽  
Călin Jianu ◽  
Alexandra Teodora Lukinich-Gruia ◽  
Marius Mioc ◽  
Alexandra Mioc ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
In Silico ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Inhibitory Effect ◽  
Melissa Officinalis ◽  
Β Carotene

The investigation aimed to study the in vitro and in silico antioxidant properties of Melissa officinalis subsp. officinalis essential oil (MOEO). The chemical composition of MOEO was determined using GC–MS analysis. Among 36 compounds identified in MOEO, the main were beta-cubebene (27.66%), beta-caryophyllene (27.41%), alpha-cadinene (4.72%), caryophyllene oxide (4.09%), and alpha-cadinol (4.07%), respectively. In vitro antioxidant properties of MOEO have been studied in 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging, and inhibition of β-carotene bleaching assays. The half-maximal inhibitory concentration (IC50) for the radical scavenging abilities of ABTS and DPPH were 1.225 ± 0.011 μg/mL and 14.015 ± 0.027 μg/mL, respectively, demonstrating good antioxidant activity. Moreover, MOEO exhibited a strong inhibitory effect (94.031 ± 0.082%) in the β-carotene bleaching assay by neutralizing hydroperoxides, responsible for the oxidation of highly unsaturated β-carotene. Furthermore, molecular docking showed that the MOEO components could exert an in vitro antioxidant activity through xanthine oxidoreductase inhibition. The most active structures are minor MOEO components (approximately 6%), among which the highest affinity for the target protein belongs to carvacrol.

scholarly journals In Vitro Pharmaco-Toxicological Characterization of Melissa officinalis Total Extract Using Oral, Pharynx and Colorectal Carcinoma Cell Lines

Processes ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 850
Author(s):  
Kristine Guran ◽  
Roxana Buzatu ◽  
Iulia Pinzaru ◽  
Madalina Boruga ◽  
Iasmina Marcovici ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Melissa Officinalis ◽  
Pharmacological Profile ◽  
In Ovo ◽  
Total Extract ◽  
Antiangiogenic Effect ◽  
Beneficial Effects ◽  
Gram Positive Bacteria ◽  
Potential Benefits

Melissa officinalis is a medicinal herb with an extensive pharmacological profile that has been proven to have beneficial effects in oral and gastrointestinal disorders. However, the effects of this plant in oral, pharyngeal, and colorectal malignancies, types of cancer with an increased incidence in recent years, are less investigated. The present study aims to evaluate the pharmacological profile of a Melissa officinalis total extract for potential benefits in oral, pharynx and colorectal carcinoma. The LC-MS profile of MO total extract (MOte) indicated a rich content in polyphenols, data that support the potent antioxidant capacity exhibited and the antimicrobial activity against both Gram-negative and Gram-positive bacteria. In addition, MOte triggered a dose-dependent and selective decrease in the viability of tumor cells (tongue and pharynx squamous cell carcinomas, and colorectal adenocarcinoma), with the most significant effect being recorded at 100 µg/mL. At the same concentration, MOte exhibited an antiangiogenic effect by inhibiting the process of angiogenesis in ovo. Overall, our findings support the potential benefits of Melissa officinalis leaf total extract as a valuable candidate for the prophylaxis of oral, pharyngeal and colorectal neoplasms.

Characterization of volatile components in Melissa officinalis L. under in vitro conditions

2016 ◽  
Vol 29 (4) ◽  
pp. 299-303 ◽  
Author(s):  
Sam Mokhtarzadeh ◽  
Betul Demirci ◽  
Gamze Goger ◽  
Khalid Mahmood Khawar ◽  
Nese Kirimer
Keyword(s):  
Volatile Components ◽  
Melissa Officinalis

scholarly journals Systematic comparison of nutraceuticals and antioxidant potential of cultivated, in vitro cultured and commercial Melissa officinalis samples

2012 ◽  
Vol 50 (6) ◽  
pp. 1866-1873 ◽  
Author(s):  
Maria Inês Dias ◽  
Lillian Barros ◽  
Maria João Sousa ◽  
Isabel C.F.R. Ferreira
Keyword(s):  
Antioxidant Potential ◽  
Melissa Officinalis ◽  
Systematic Comparison

scholarly journals Novel Therapeutic Approach for the Management of Mood Disorders: In Vivo and In Vitro Effect of a Combination of L-Theanine, Melissa officinalis L. and Magnolia officinalis Rehder & E.H. Wilson

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1803 ◽  
Author(s):  
Vittoria Borgonetti ◽  
Paolo Governa ◽  
Marco Biagi ◽  
Nicoletta Galeotti
Keyword(s):  
Mood Disorders ◽  
Mechanism Of Action ◽  
Neuroprotective Effect ◽  
Endocannabinoid System ◽  
Antidepressant Activity ◽  
Melissa Officinalis ◽  
Magnolia Officinalis ◽  
Vitro Effect

Mood disorders represent one of the most prevalent and costly psychiatric diseases worldwide. The current therapies are generally characterized by several well-known side effects which limit their prolonged use. The use of herbal medicine for the management of several psychiatric conditions is becoming more established, as it is considered a safer support to conventional pharmacotherapy. The aim of this study was to investigate the possible anxiolytic and antidepressant activity of a fixed combination of L-theanine, Magnolia officinalis, and Melissa officinalis (TMM) in an attempt to evaluate how the multiple modulations of different physiological systems may contribute to reducing mood disorders. TMM showed an anxiolytic-like and antidepressant-like activity in vivo, which was related to a neuroprotective effect in an in vitro model of excitotoxicity. The effect of TMM was not altered by the presence of flumazenil, thus suggesting a non-benzodiazepine-like mechanism of action. On the contrary, a significant reduction in the effect was observed in animals and neuronal cells co-treated with AM251, a cannabinoid receptor type 1 (CB1) antagonist, suggesting that the endocannabinoid system may be involved in the TMM mechanism of action. In conclusion, TMM may represent a useful and safe candidate for the management of mood disorders with an innovative mechanism of action, particularly as an adjuvant to conventional therapies.

scholarly journals Teor e composição química do óleo essencial de Melissa officinalis L. in vitro sob influência do meio de cultura

2009 ◽  
Vol 31 (2) ◽  
Author(s):  
Érika Soares Reis ◽  
José Eduardo Brasil Pereira Pinto ◽  
Luciana Domiciano Silva Rosado ◽  
Ricardo Monteiro Corrêa
Keyword(s):  
Melissa Officinalis
Sign in / Sign up

Export Citation Format

Share Document