EVALUATING THE UTILITY OF FINE-NEEDLE ASPIRATION CYTOLOGY(FNAC) IN LYMPH NODE PATHOLOGIES- A FOLLOW-UP STUDY

2021 ◽  
pp. 39-40
Author(s):  
Kirti Priya ◽  
Sujeet Kumar Bharti
Keyword(s):  
Lymph Node ◽  
Hodgkin’S Lymphoma ◽  
Cost Effective ◽  
Surgical Excision ◽  
Clinical Problem ◽  
Needle Aspiration ◽  
Hodgkin's Lymphoma ◽  
Neck Masses ◽  
The Difference ◽  
Metastatic Neoplasm

Background: Lymphadenopathy or adenopathy is an often encountered clinical problem with many causes ranging from inammatory to malignant process. The present study was conducted to assess the cases of lymphadenopathy using FNAC. Materials & Methods: This study comprised of 140 patients of male and female with neck masses. All patients underwent to FNA and subsequently surgical excision of their neck masses. Smears were then prepared and marked with Pap method. Results: Out of 140 cases, males were 80 and females were 60. The difference was non- remarkable (P- 0.1). Out of 140 cases, 105 were benign and 35 were malignant. In begin lesions, 70 were in males and 40 were in females and in malignant cases, 15 were in males and 15 were in females. The difference was signicant (P- 0.01). Metastatic neoplasm was seen in 11 males and 9 females, hodgkin's lymphoma in 5 males and 4 females, and non- hodgkin's lymphoma in 4 males and 2 females. The difference was nonsignicant (P> 0.05). Conclusion: FNAC is the simple, safe, reliable, and cost-effective procedure for initial screening of various lymph node pathologies.

scholarly journals Clinicopathological Correlation in Patients of Lymphadenopathy in Tertiary Care Hospital

2018 ◽  
Vol 3 (12) ◽  
Author(s):  
Dr. Amol R. Rajhans, MD ◽  
Dr. Deepak S. Howale
Keyword(s):  
Lymph Node ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Cost Effective ◽  
Clinical Problem ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Lymph nodes are parts of the lymphatic system. Lymph node helps to filter out viruses, bacteria, cancer cells and other unwanted substances safely removed from the body. Lymphadenopathy is common clinical problem frequently give dilemma in diagnostic. Enlargement of lymph node is a common problem which evaluate as a Lymphadenopathy. An abnormality in size and character of lymph node in known as Lymphadenopathy which also consider as enlarged abnormally that measures more than 10mm in its diameter than normal. Lymphadenopathy is common clinical problem frequently give dilemma in diagnostic. Fine needle aspiration cytology (FNAC) has become an important tool for initial diagnosis and management for patients suffering from Lymphadenopathy because of early result, simple for test and minimal trauma to patient. The main aim of this study is to Correlation of Clinicopathological condition presenting with Lymphadenopathy. Role of FNAC in diagnosis will also evaluate with node biopsy and open lymph. Material and methods: Total 100 patients were included in this study. For all 100 patients fine needle aspiration cytology (FNAC) was done. In 75 cases excision biopsy was done. Pathological diagnosis was obtained in all cases. Fine needle aspiration cytology, excision biopsy, throat, ear and nose examination were carried out as a required base line investigations. Result: Total 80 patients were studies in this study. Out of this 80 patients 30 cases were IPD and remaining were OPD. FNAC as well as biopsy were carried out from total patients in this study. In this study Tubercular Lymphadenitis was observer maximum. Out of 80 patients 47(58.75%) were male and 33(41.25%) were female patients. Age group 20-30 years (35%) were maximum number of patients which was followed by 30-40 years (23.75%) and 10-20 years (21.25%) respectively was observed. Out of 80 patients 50(62.5%) were diagnosis as Tubercular Lymphadenitis and Chronic Non-specific Lymphadenitis was diagnosis in 10 (12.5%). Reactive lymphadenitis was diagnosed in 8(10%) patients whereas Malignant secondary’s were diagnosed in 7(8.75%) patients followed by 3(3.75%) patients suffer from lymphomas and 2(2.5%) were Non- Hodgkin's Lymphoma. Conclusion: Lymphadenopathy is a clinical evaluation followed by FNAC which is reliable diagnostic tool that is easy to perform; cost effective, speedy results accurate can be obtained. Specialist input is the main requirement for this. Biopsy is also useful in cases of lymphomas that act as diagnostic tool. When FNAC report is inconclusive, in nonspecific lymphadenitis than Biopsy is much helpful for accurate diagnosis and management. Hence, in cases of Lymphadenopathy FNAC was found to be reliable, simple and cost effective method for diagnosis.

scholarly journals Efficacy of fine needle aspiration cytology in the diagnosis of lymphadenopathies

2017 ◽  
Vol 5 (4) ◽  
pp. 1607
Author(s):  
Rasheed Fatima ◽  
Sandhya M.
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Cost Effective ◽  
Surgical Excision ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Histopathological Diagnosis ◽  
Fine Needle

Background: Enlarged lymph nodes were the first organs to be diagnosed by fine needle aspiration. Objectives were to study the role of FNAC in the evaluation of lymphadenopathies, to study the various cyto-morphological patterns in correlation with histopathology of various lymph node lesions and to document the diagnostic accuracy of FNAC in correlation with histopathology.Methods: All patients referred to the department of pathology K.V.G. Medical College and Hospital, Sullia, Karnataka, India for FNAC of palpable lymph nodes were included in present study. FNAC was done and the standard method for the procedure adopted. All the slides were reviewed and their diagnosis was made. FNAC diagnosis was compared with histopathology in cases which underwent surgical excision and thus its diagnostic accuracy determined. This was two years and two months’ prospective study from July 2008 to August 2010.Results: A total of` 150 patients were included in the present study, reported to various clinical departments with history of swelling. Lymph node biopsy was done in 50 cases. Statistical analysis was done in 50 cases, where FNAC diagnosis was correlated well with histopathological diagnosis. Maximum number of cases was in the age group of 31-40 years. Present study showed female preponderance of cases. Cervical group of nodes were most commonly involved. Benign lymphadenopathies were diagnosed in 69.8% of cases. Maximum number of cases being reactive lymphadenitis (65.4%). Metastatic deposit was diagnosed in 23.5% of cases. Most common subtype being adenocarcinoma. Lymphomas were diagnosed in 09 cases. 1 case of Hodgkin’s lymphoma and 8 cases of NHL were diagnosed. The overall correlation between FNAC and histopathology was 98% (49 out of 50).Conclusions: FNAC is an accurate, sensitive, specific and cost effective procedure in the diagnosis of lymphadenopathies.

CYTOPATHOLOGICAL SPECTRUM OF FNAC IN PALPABLE HEAD AND NECK LESIONS

2021 ◽  
pp. 53-54
Author(s):  
Devendu Bose ◽  
Bejoy Chand Banerjee
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Soft Tissue ◽  
Head And Neck ◽  
Clinical History ◽  
Needle Aspiration ◽  
Minimal Risk ◽  
Neck Swelling ◽  
Neck Masses ◽  
Common Diagnosis

Introduction: Head and neck lesions comprises a large number of congenital, inammatory or neoplastic lesions including different anatomic sites and originating in different tissues and organs. Fine needle aspiration cytology (FNAC) is a simple, quick, feasible, repeatable and outpatient procedure with minimal risk of complication. Aim: To study the role of FNAC and its utility in diagnosis of palpable head neck masses and to determine the spectrum of various lesions. Materials And Methods: A retrospective study was conducted in pathology department of Shaheed Nirmal Mahato Medical College, Dhanbad, Jharkhand from January 2016 to December 2020 on patients with palpable head and neck swelling. Detailed clinical history of patient was noted. Aspirations were done by using 10 ml syringe and 22/23 gauge needles. Smears were stained with PAP, Haematoxylin and Eosin and Leishman stain. Cytomorphological diagnosis was given. Results: Out of 562 patients of head and neck swelling, 61.92% (348 cases) were of lymph node, 20.28% (114 cases) were of thyroid, 3.38% from salivary gland (19 cases), 14.06% (79 cases) from skin and soft tissue swellings. The most common diagnosis was reactive lymphadenitis (32.74%) followed by granulomatous lymphadenitis (18.33%). The mean age of study population was 32 years. There was female preponderance (88.59%) in thyroid lesions whereas lymph node lesions (60.91%), salivary gland lesions (73.68%) and soft tissue swellings (59.49%) were more common in males. Conclusion: From our study we concluded that FNAC is simple, quick, inexpensive, repeatable and minimally invasive rst line investigation for differential diagnosis of head and neck lesions.

scholarly journals Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma

Blood ◽  
1991 ◽  
Vol 77 (7) ◽  
pp. 1527-1533 ◽  
Author(s):  
D Shibata ◽  
LM Weiss ◽  
BN Nathwani ◽  
RK Brynes ◽  
AM Levine
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymph Node ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Normal Individuals ◽  
Non Hodgkin's Lymphoma ◽  
Immunodeficiency Virus ◽  
Ebv Dna ◽  
Epstein Barr ◽  
Benign Lymph Node

Abstract Individuals infected with the human immunodeficiency virus (HIV) have an increased incidence of high-grade B-cell lymphoma. In many instances, these lymphomas contain Epstein-Barr viral (EBV) genomes. To investigate the role of EBV in development of HIV-related lymphoma, benign fixed lymph node biopsies from normal individuals and HIV- infected individuals with persistent generalized lymphadenopathy (PGL) were analyzed for EBV sequences by polymerase chain reaction and in situ DNA hybridization techniques. EBV DNA was not detected in any of 16 benign lymph node biopsies from normal individuals, but could be detected from 13 of 35 PGL biopsies. The EBV-infected cells were present in both follicular and interfollicular areas and in both small and large lymphoid cells. The presence of detectable amounts of EBV DNA in the 13 PGL biopsies was associated with an increased incidence of concurrent lymphoma at another site (n = 3) or development of lymphoma in time (n = 2). In contrast, only 1 of 22 individuals with EBV- negative PGL biopsies developed lymphoma in time (P less than .05). EBV was detected in all five lymphomas in which tissue was available for subsequent analysis, including the lymphoma that developed in the individual without EBV in his previous PGL biopsy. These findings support the hypothesis that EBV plays a role in development of some HIV- related lymphomas. Detectable EBV lymphoproliferations occur in a few PGL biopsies and are associated with a significant risk of EBV DNA- positive non-Hodgkin's lymphoma.

scholarly journals Lymph Node Infarction in Classical Hodgkin's Lymphoma

2012 ◽  
Vol 52 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Eiichiro Mori ◽  
Yasunori Enomoto ◽  
Hirokazu Nakamine ◽  
Takahiko Kasai ◽  
Maiko Takeda ◽  
...  
Keyword(s):  
Lymph Node ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma

scholarly journals Translocation (14;18)-positive cells are present in the circulation of the majority of patients with localized (stage I and II) follicular non- Hodgkin's lymphoma

Blood ◽  
1993 ◽  
Vol 82 (8) ◽  
pp. 2510-2516 ◽  
Author(s):  
AC Lambrechts ◽  
PE Hupkes ◽  
LC Dorssers ◽  
MB van't Veer
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Peripheral Blood ◽  
Hodgkin’S Lymphoma ◽  
Lymph Node Biopsy ◽  
Stage I ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Sensitive Polymerase Chain Reaction

Abstract Stage I and II follicular non-Hodgkin's lymphoma (NHL) is clinically defined as a localized disease. To study the possibility that this disease is in fact disseminated, we used the sensitive polymerase chain reaction (PCR) method using translocation (14;18) as marker. Samples from 21 patients who were clinically diagnosed with stage I or II follicular NHL were analyzed for the presence of t(14;18)-positive cells using PCR. We analyzed (1) the diagnostic lymph node biopsy and (2) the peripheral blood or bone marrow samples from these patients. Translocation (14;18) cells were detected in the diagnostic lymph node biopsies of 12 patients. In 9 of these patients, t(14;18)-positive cells were detected in peripheral blood and/or bone marrow samples at diagnosis and/or after therapy. Thus, in 75% of the follicular NHL patients carrying the t(14;18) as a marker for lymphoma cells, t(14;18)- positive cells were detected in peripheral blood and bone marrow at diagnosis and after therapy. Our results show that t(14;18)-positive cells can be detected in the circulation of patients with stage I and II follicular NHL, indicating that, although diagnosed as localized, the disease is disseminated.

scholarly journals Cholangiocarcinoma Metastatic to the Neck: First Report of a Case

2002 ◽  
Vol 81 (11) ◽  
pp. 776-778 ◽  
Author(s):  
Scott H. Hardeman ◽  
Brian Collins ◽  
Val J. Lowe ◽  
Harvey Solomon ◽  
Brendan C. Stack
Keyword(s):  
Lymph Node ◽  
Cervical Lymph Node ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Unique Case ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Neck Masses ◽  
Needle Aspiration Cytology ◽  
Head And Neck Masses

We describe a unique case of a cholangiocarcinoma that metastasized to a cervical lymph node—to our knowledge the only such case ever reported. The diagnosis was based on fine-needle aspiration cytology and confirmed by excision biopsy. This case illustrates the importance of keeping all possible options in mind when diagnosing head and neck masses.

Cytodiagnostic Sensitivity of Fine Needle Aspiration Biopsy for Hodgkin’s Lymphoma Is Decreased in Patients with Human Immunodeficiency Virus Infection

2019 ◽  
Vol 63 (5) ◽  
pp. 352-360 ◽  
Author(s):  
Adam J. Perricone ◽  
Mohammad K. Mohammad ◽  
Rachel L. Geller ◽  
Marina B. Mosunjac
Keyword(s):  
Fine Needle Aspiration ◽  
Hodgkin’S Lymphoma ◽  
Needle Aspiration ◽  
Diagnostic Sensitivity ◽  
Hodgkin's Lymphoma ◽  
P Value ◽  
Hiv Patients ◽  
Female Ratio ◽  
Fine Needle ◽  
Significant Difference

Objective: We aimed to evaluate the sensitivity of fine needle aspiration (FNA) for the diagnosis of Hodgkin’s lymphoma (HL) in HIV-infected patients. Study Design: An electronic search was conducted to retrospectively identify patients diagnosed with HL who underwent FNA followed by confirmatory biopsy. FNAs were categorized as negative, atypical/suspicious/positive, or nondiagnostic. Diagnostic sensitivity in HIV+ and HIV– patients was statistically compared via Fisher’s exact test, with a p value <0.05 considered significant. Results: Thirty-six patients meeting inclusion criteria were identified (24 HIV– and 12 HIV+). Average age was 36.0 ± 11.5 and 36.5 ± 7.4 years (means ± SD) in HIV– and HIV+ patients, respectively. The male-to-female ratio was 1.4:1 in HIV– patients versus 3:1 in HIV+ patients. Among these 36 patients, a total of 42 FNAs were performed. Overall sensitivity of FNA was 66.7% (95% confidence interval: 52.4–80.9%). When stratified by HIV status, a statistically significant difference in FNA sensitivity was detected, as sen­sitivity was 84.6% (70.8–98.4%) in HIV– patients versus only 37.5% (13.8–61.2%) in HIV+ patients (p =0.003). Conclusion: The diagnostic sensitivity of FNA biopsy was significantly attenuated in the HIV+ cohort. In HIV-infected patients presenting with lymphadenopathy, increased clinical suspicion of HL is critical to avoid misdiagnosis.

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