“COMPARISON OF ATHEROGENIC INDEX OF PLASMA AND CHOLESTEROL/HDL RATIO AMONG TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE HOSPITAL”

Risk Group ◽

Atherogenic Index ◽

P Value ◽

Lipid Ratios ◽

Cardio Vascular

Lipid prole though is a well established parameter to predict cardio vascular risk in patients suffering from type 2 diabetes mellitus(T2DM), at present lipid ratios are replacing these age old parameters. Among the lipid ratios Atherogenic index of plasma(AIP) and cholesterol/HDL(Chol/HDL) are found to be of great signicance. This cross-sectional study aimed to compare the predictive value of two lipid ratios, "Atherogenic index of plasma" (AIP) and "Cholesterol/HDL ratio" on basis of insulin resistance (IR) among 55 newly diagnosed cases with Type 2 Diabetes Mellitus (T2DM) and 50 control subjects. HOMA –IR (p value <0.0001), AIP (<0.001) and Cholesterol/HDL ratio (<0.001) were signicantly raised among case group in comparison to controls. Both AIP(r- 0.305, p-0.002) and Chol/HDL ratio(r- 0.23, p value- 0.018) was signicantly correlated with HOMA-IR. ROC curve of AIP and Chol/HDL ratio was plotted for identifying IR. There is no signicant difference between areas under curve (AUC) of AIP (AUC-0.656) and Chol/HDL ratio(AUC-0.630) (p value- 0.49). AIP was found to be correlated better with Insulin resistance than CHOL/HDL ratio. AUC in AIP was found to be slightly higher and overall sensitivity and specicity of AIP was found to be 66% and 69%, of Chol/HDL ratio was 46% and 76% to identify moderate to high-risk group: whereas it is 69%&47% of AIP and 87% and 32% of Chol/HDL ratio to identify low risk group. Both lipid ratios have some signicance in predicting cardio vascular risk in T2DM

Lipid ratios, atherogenic coefficient and atherogenic index of plasma as parameters in assessing cardiovascular risk in type 2 diabetes mellitus

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20161966 ◽

2016 ◽

pp. 2863-2869 ◽

Cited By ~ 8

Author(s):

Harini Nimmanapalli ◽

Ambika Kasi ◽

Prabath Devapatla ◽

Vani Nuttakki

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Cardiovascular Risk ◽

Atherogenic Index ◽

Lipid Ratios

Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2020-0090 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Hadi Bazyar ◽

Seyed Ahmad Hosseini ◽

Sirous Saradar ◽

Delsa Mombaini ◽

Mohammad Allivand ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Type 2 Diabetes ◽

Lipid Profile ◽

Atherogenic Index ◽

Control Group ◽

The Mean

Abstract Background In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown. Objectives Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM. Methods In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention. Results The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05). Conclusions This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.

Chromium Picolinate and Biotin Combination Reduces Atherogenic Index of Plasma in Patients with Type 2 Diabetes Mellitus: A Placebo-Controlled, Double-Blinded, Randomized Clinical Trial

The American Journal of the Medical Sciences ◽

10.1097/maj.0b013e318031b3c9 ◽

2007 ◽

Vol 333 (3) ◽

pp. 145-153 ◽

Cited By ~ 32

Author(s):

Jeff Geohas ◽

Anne Daly ◽

Vijaya Juturu ◽

Manley Finch ◽

James R. Komorowski

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Clinical Trial ◽

Randomized Clinical Trial ◽

Atherogenic Index ◽

Chromium Picolinate ◽

Double Blinded

Atherogenic index of plasma is associated with major adverse cardiovascular events in patients with type 2 diabetes mellitus

10.21203/rs.3.rs-829355/v1 ◽

2021 ◽

Author(s):

Liyao Fu ◽

Ying Zhou ◽

Jiaxing Sun ◽

Zhaowei Zhu ◽

Zhenhua Xing ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Cardiovascular Events ◽

Atherogenic Index ◽

Confounding Factors ◽

All Cause Mortality ◽

Study Population

Abstract Background Previous studies have reported the prognostic value of the atherogenic index of plasma (AIP) in the course of atherosclerosis and other cardiovascular diseases (CVDs). However, the utility of the AIP for prediction is unknown among patients with type 2 diabetes mellitus (T2DM). Methods This was a secondary analysis of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study which randomized 10,251 patients with long-lasting T2DM. ROC curve analysis was used to determine an optimal threshold for AIP and the study population was divided into high and low AIP groups. Univariate and multivariate Cox proportional hazards regression analyses were used to find the association between AIP and primary (MACEs) and second outcomes (all-cause mortality). Stratified analyses were performed to control the confounding factors. Results AIP was an independent risk factor for the prognosis of T2DM (HR = 1.309; 95% CI, 1.084–1.581; P = 0.005). The threshold for AIP was determined to be 0.34 among the study population. After adjustments for confounding factors, multivariate analysis showed that AIP was associated with the risk of MACEs (Model 1: HR = 1.333, 95%CI: 1.205–1.474, P༜0.001; Model 2: HR = 1.171, 95%CI: 1.030–1.333, P = 0.016; Model 3: HR = 1.194, 95%CI: 1.049–1.360, P = 0.007) and all-cause mortality (Model 1: HR = 1.184, 95%CI: 1.077–1.303, P༜0.001), especially cardiovascular deaths (Model 1: HR = 1.422, 95%CI: 1.201–1.683, P༜0.001; Model 3: HR = 1.264, 95%CI: 1.015–1.573, P = 0.036) and nonfatal myocardial infarction (Model 1: HR = 1.447, 95%CI: 1.255–1.669, P༜0.001; Model 2: HR = 1.252, 95%CI: 1.045–1.499, P = 0.015; Model 3: HR = 1.284, 95%CI: 1.071–1.539, P = 0.007). Subgroup stratified analyses showed that AIP might interact with gender, a classical risk factor of cardiovascular events. Conclusions Our study showed that AIP might be a strong biomarker that could be used to predict the risk of cardiovascular events in patients with T2DM.

Evaluation of lipid profile pattern and atherogenic index of plasma (AIP) having type-2 diabetes mellitus in Bangladesh

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20180595 ◽

2018 ◽

Vol 6 (3) ◽

pp. 776

Author(s):

Mahfuza Anjum ◽

Md. Salah Uddin ◽

Naima Ahmed Tamanna ◽

Md. Abdullah Al-Zobair ◽

A. T. M. Mijanur Rahman

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Density Lipoprotein ◽

Atherogenic Index ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Background: Dyslipidemia has been noted to play an integral role in the pathogenesis and progression of micro and macrovascular complications in Diabetes Mellitus (DM) patients. The study was aimed to evaluate the prevalence and pattern of dyslipidemia and atherogenic index of plasma (AIP) in type 2 diabetes mellitus patients as it has not been reported previously in BangladeshMethods: This cross-sectional study was conducted at Armed Forces Institute of pathology, Bangladesh from November 2016 to October 2017. A total number of 300 patients having diabetes in the age group of 30-60 years have been selected using a non-probability method. Fasting plasma glucose (FPG), serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels were estimated by laboratory tests.Results: The prevalence of dyslipidemia in at least one lipid parameter was found in 282 patients (94%), while 18 patients (6%) had no dyslipidemia. High levels of TC, TG and LDL-C were found in 134 (47.3%), 230 (76.7%) and 124 (41.3%) patients, respectively. On the other hand, low levels of HDL-C were found in 180 patients (60%). An increased risk of AIP was found in 298 patients (99.3%), whereas only 2 patients (0.7%) were in low risk. FPG was positively correlated with TC, TG, LDL-C and AIP, while negatively correlated with HDL-C. A significant positive correlation was also observed between FPG and AIP.Conclusions: The Study revealed that dyslipidemia is very common in type 2 diabetic patients and the most common abnormality observed was increased serum triglyceride levels followed by decreased serum HDL-C levels. The AIP is also significantly higher in type 2 diabetic patients.