CUTANEOUS SQUAMOUS CELL CARCINOMA- A CASE REPORT

Cutaneous squamous cell carcinoma (cSCC) is a malignant neoplasm of the skin characterized by an aberrant 1 proliferation of keratinocytes. The usual presentation of skin malignancies include ulceration, growth, a change in mole, unusual form or bleeding due to various etiological factors. There exists a diagnostic challenge, as many benign conditions present similarly, thereby altering the treatment strategy. 2 Although Cutaneous Squamous Cell Carcinoma usually display a benign clinical behaviour, it can be both locally invasive and metastatic Here we report a case of an elderly female who presented with a proliferative growth in right forearm for the past 1 year, from a pre-existing mole, which on examination had features of all the three cutaneous malignancies resulting in a diagnostic uncertainty and which on further workup was diagnosed as a well differentiated squamous cell carcinoma

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A Case of Verrucous Carcinoma (Epithelioma Cuniculatum) of the Heel Mimicking Infected Epidermal Cyst and Gout

Foot & Ankle Specialist ◽

10.1177/1938640008322689 ◽

2008 ◽

Vol 1 (5) ◽

pp. 297-299 ◽

Cited By ~ 4

Author(s):

Mahbod Arefi ◽

Elizabeth Philipone ◽

Russell Caprioli ◽

John Haight ◽

Hugh Richardson ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Rare Variant ◽

Squamous Cell ◽

Verrucous Carcinoma ◽

Epidermal Cyst ◽

Diagnostic Challenge ◽

Epithelioma Cuniculatum ◽

Well Differentiated

Verrucous carcinoma is a rare variant of well-differentiated squamous cell carcinoma. It usually occurs in the oral cavity, genital area, and sole. Verrucous carcinoma of the sole, also called epithelioma cuniculatum, often presents a diagnostic challenge both clinically and histopathologically. The authors report such a case that mimics infected epidermal cyst and gout clinically

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Atypical presentation of adenosquamous carcinoma: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x18801217 ◽

2018 ◽

Vol 6 ◽

pp. 2050313X1880121

Author(s):

Annie Genois ◽

Catherine Maari ◽

Danielle Bouffard

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Clinical Presentation ◽

Adenosquamous Carcinoma ◽

Malignant Neoplasm ◽

Atypical Presentation ◽

Rare Tumour ◽

The Past ◽

Prompt Diagnosis

Cutaneous adenosquamous carcinoma is a rare malignant neoplasm that is more aggressive than conventional squamous cell carcinoma. The typical clinical presentation is an indurated papule or plaque on the head and neck of elderly patients. The authors report the case of a 52-year-old man with a right scrotal and inguinal tumour measuring 10 cm × 15 cm that had progressed over the past 2 years. The histological examination was compatible with adenosquamous carcinoma. Metastatic inguinal and pelvic lymph nodes were identified. This case demonstrates an atypical presentation of a rare tumour. Adenosquamous carcinoma is more aggressive than conventional squamous cell carcinoma, and prompt diagnosis is important.

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Expression levels of angiogenic growth factors in feline squamous cell carcinoma

Acta Veterinaria Hungarica ◽

10.1556/004.2020.00005 ◽

2020 ◽

Vol 68 (1) ◽

pp. 37-48

Author(s):

Yonca B. Kabak ◽

Mahmut Sozmen ◽

Alparslan K. Devrim ◽

Mert Sudagidan ◽

Funda Yildirim ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Growth Factors ◽

Cell Carcinoma ◽

Squamous Cell ◽

Tumour Progression ◽

Malignant Neoplasm ◽

The Body ◽

Angiogenic Growth Factors ◽

Expression Levels ◽

Well Differentiated

AbstractSquamous cell carcinoma (SCC) is the most common malignant neoplasm of the skin in cats. Tumour angiogenesis is the pivotal event for tumour progression and metastasis. We assessed protein and gene expression of angiogenic growth factors including bFGF, VEGF-C, TGF-β, PDGF-A, PDGF-C and PDGFR-α that possibly contribute to the angiogenic phenotype of feline SCC (FSCC) and could, therefore, be a good target in the treatment of SCC. In the present study, a total of 27 FSCC cases were investigated. Tumour cases were histopathologically classified as well differentiated (10/27), moderately differentiated (5/27), and poorly differentiated (12/27). The expression levels of the growth factors were detected using immunohistochemistry and assessed semi-quantitatively. Growth factor expression levels were evaluated at different locations: in the oral region, in areas exposed to solar UV radiation including the ears, eyelids and nasal planum, and other miscellaneous locations. Our findings have revealed that FSCC arising from different anatomical sites of the body and showing differences in aggressiveness, metastasis, and prognosis may be angiogenesis dependent, and angiogenic key regulators could play a role in the development of FSCC.

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Assessment of stromal eosinophilia in cutaneous squamous cell carcinoma

AL-Kindy College Medical Journal ◽

10.47723/kcmj.v15i1.74 ◽

2019 ◽

Vol 15 (1) ◽

pp. 30-35

Author(s):

Farah Falah Hassan Abu deka

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Cutaneous Squamous Cell Carcinoma ◽

Histological Grading ◽

Stromal Invasion ◽

Predictive Tool ◽

Tissue Eosinophilia ◽

Level Of Invasion ◽

Well Differentiated

Background: Tumor associated tissue eosinophilia (TATE) has been described in a variety of neoplasms. In regard to squamous cell carcinoma, some studies worldwide done to assess stromal eosinophilia in oral and cervical squamous cell carcinoma. The objectives of this study is to evaluate the association of stromal eosinophilic infiltration of cutaneous squamous cell carcinoma and to detect the significance of this association. Aim of the study The aim of our study is to establish the relationship between the degree of stromal eosinophilia and the level of invasion and the histological grade in cutaneous squamous cell carcinoma. Methods: In this retrospective study done at the histopathology department of al Wasity teaching hospital for orthopedic and plastic surgery in Baghdad, all paraffin embedded blocks for excisional biopsies diagnosed as primary cutaneous squamous cell carcinoma from December 2015 to January 2017 were retrieved. Incisional biopsies and those with margin positive tumor cells were excluded. After a careful evaluation for histological grading and assessment of level of invasion according to an established histological criteria , the assessment of tissue eosinophils was done by three pathologist through counting eosinophils in tumor stroma in 10 high power field using a light microscope and categorized as none (0,),low (1-4),medium (5-19)and high (more than 20). Results : of 56 cases of primary cutaneous squamous cell carcinoma 48(85.7%) cases were conventional .The mean age was 43.14 ± 1.76 .Regarding conventional squamous cell carcinoma ,of 48 cases 30(62.5) were well differentiated,16(33.3%) had clarck level III,18(37.5%) had clarck level IV and 14(29.1%) had Clark level V .There is a significant statistical relationship between histological grading of tissue eosinophilia and level of invasion with p value 0.044 and a non-significant relationship with degree of differentiation. Conclusion :The majority of cutaneous squamous cell carcinomas were conventional well differentiated with a mean age in the fifth decade of life ,a male predominance and often had a degree of stromal eosinophilia that is strongly associated with the level of invasion .Thus more Intense tissue eosinophilia is correlated with a higher level of stromal invasion. The significance of such an association should be regarded as either a potential predictive tool for stromal invasion in small incisional biopsy or as a prognostic indicator that could be included in the pathology report for conventional squamous cell carcinoma

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Argon–Helium Cryoablation for Cutaneous Squamous Cell Carcinoma in the Elderly

Frontiers in Oncology ◽

10.3389/fonc.2021.788490 ◽

2022 ◽

Vol 11 ◽

Author(s):

Qianwen Huang ◽

Wenshen Xu

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Malignant Neoplasm ◽

The Elderly ◽

Cutaneous Squamous Cell Carcinoma ◽

Surgical Removal ◽

Non Melanoma Skin Cancer ◽

Good Cosmetic ◽

Cosmetic Outcomes

Cutaneous squamous cell carcinoma (cSCC) is a common type of malignant neoplasm in non-melanoma skin cancer (NMSC). Most cases of simple cSCC are considered curable by surgical removal of the lesion. However, clinical treatments for cSCC with medium- or large-sized lesions are difficult. Meanwhile, the effectiveness of the treatments is not guaranteed, especially for elderly patients, because of an intolerance to surgical resection or other adjuvant modalities. In such cases, safe and effective treatments with excellent aesthetic outcomes are urgently needed. In this study, we reported 6 elderly cSCC patients with medium- or large-sized lesions treated with argon–helium cryoablation. The average age of all 6 patients was 78 years (range 72–85 years). They were all diagnosed with cSCC with a median tumor size of 5.8 cm (range 2.5–15.5 cm) and dermal invasion. Complete ablation was achieved in all cases after a single ablation session (2 freeze–thaw cycles). Patients experienced mild pain and hemorrhage after ablation, but the symptoms were manageable. One patient developed infection and fever because of extensive necrosis of the tumor, which was eventually cured after treatment. All patients obtained good cosmetic outcomes, and their quality of life improved significantly. In the 5-year follow-up study, 4 patients were alive while 2 patients died of unrelated diseases 3 years after cryotherapy. None of the 6 patients had a recurrence. These results suggested the feasibility of argon–helium cryoablation as a novel therapeutic strategy for elderly cSCC with medium- or large-sized lesions.

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