scholarly journals Expression levels of angiogenic growth factors in feline squamous cell carcinoma

2020 ◽  
Vol 68 (1) ◽  
pp. 37-48
Author(s):  
Yonca B. Kabak ◽  
Mahmut Sozmen ◽  
Alparslan K. Devrim ◽  
Mert Sudagidan ◽  
Funda Yildirim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumour Progression ◽  
Malignant Neoplasm ◽  
The Body ◽  
Angiogenic Growth Factors ◽  
Expression Levels ◽  
Well Differentiated

AbstractSquamous cell carcinoma (SCC) is the most common malignant neoplasm of the skin in cats. Tumour angiogenesis is the pivotal event for tumour progression and metastasis. We assessed protein and gene expression of angiogenic growth factors including bFGF, VEGF-C, TGF-β, PDGF-A, PDGF-C and PDGFR-α that possibly contribute to the angiogenic phenotype of feline SCC (FSCC) and could, therefore, be a good target in the treatment of SCC. In the present study, a total of 27 FSCC cases were investigated. Tumour cases were histopathologically classified as well differentiated (10/27), moderately differentiated (5/27), and poorly differentiated (12/27). The expression levels of the growth factors were detected using immunohistochemistry and assessed semi-quantitatively. Growth factor expression levels were evaluated at different locations: in the oral region, in areas exposed to solar UV radiation including the ears, eyelids and nasal planum, and other miscellaneous locations. Our findings have revealed that FSCC arising from different anatomical sites of the body and showing differences in aggressiveness, metastasis, and prognosis may be angiogenesis dependent, and angiogenic key regulators could play a role in the development of FSCC.

CUTANEOUS SQUAMOUS CELL CARCINOMA- A CASE REPORT

2021 ◽  
pp. 28-29
Author(s):  
Suprajha K.S. ◽  
Manimaran Manimaran ◽  
Barathiraja Barathiraja
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Neoplasm ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Diagnostic Challenge ◽  
Diagnostic Uncertainty ◽  
The Past ◽  
Proliferative Growth ◽  
Well Differentiated

Cutaneous squamous cell carcinoma (cSCC) is a malignant neoplasm of the skin characterized by an aberrant 1 proliferation of keratinocytes. The usual presentation of skin malignancies include ulceration, growth, a change in mole, unusual form or bleeding due to various etiological factors. There exists a diagnostic challenge, as many benign conditions present similarly, thereby altering the treatment strategy. 2 Although Cutaneous Squamous Cell Carcinoma usually display a benign clinical behaviour, it can be both locally invasive and metastatic Here we report a case of an elderly female who presented with a proliferative growth in right forearm for the past 1 year, from a pre-existing mole, which on examination had features of all the three cutaneous malignancies resulting in a diagnostic uncertainty and which on further workup was diagnosed as a well differentiated squamous cell carcinoma

scholarly journals Expression levels of insulin-like growth factors 1 and 2 in head and neck squamous cell carcinoma

2014 ◽  
Vol 24 (4) ◽  
pp. 137-141 ◽  
Author(s):  
Xu Zhi ◽  
Katarzyna Lamperska ◽  
Paweł Golusinski ◽  
Nicholas J. Schork ◽  
Lukasz Luczewski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Expression Levels ◽  
Insulin Like Growth Factors

Significance of Angiogenic Growth Factors in Bovine Ocular Squamous Cell Carcinoma

2019 ◽  
Vol 170 ◽  
pp. 60-69 ◽  
Author(s):  
M. Sözmen ◽  
A.K. Devrim ◽  
M. Sudağıdan ◽  
Y.B. Kabak ◽  
E. Beytut ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Growth Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Angiogenic Growth Factors

scholarly journals Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984735 ◽  
Author(s):  
Catherine F Roy ◽  
Simon F Roy ◽  
Feras M Ghazawi ◽  
Erica Patocskai ◽  
Annie Bélisle ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Rare Complication ◽  
Excisional Biopsy ◽  
Necrosis Factor Alpha ◽  
Spindle Cells ◽  
Poorly Differentiated ◽  
Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

scholarly journals Rural profile of oral squamous cell carcinoma (OSCC) survival patients attending in tertiary level hospital in Bogura: a hospital based retrospective observational study.

2020 ◽  
Vol 10 (1) ◽  
pp. 3-5
Author(s):  
Parometa Barma ◽  
Ibrahim Khalil ◽  
Tanzima Yeasmin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Malignant Neoplasm ◽  
P Value ◽  
Oral Epithelium ◽  
Tertiary Level ◽  
Total Cancer ◽  
Grade Ii

Developing country like Bangladesh among 90% of oral malignant neoplasm are arising from squamous layer of oral epithelium which are third leading of this country with severe disfiguration, functiolaesa, psychological impairments and socio-economic hardship. In this study we found the prevalence of OSCC was 6.5% among total cancer patients in the two tertiary level hospitals of Bogura. Male (70%) are affected more than in females (30%). In response to male and female parameter, sex distribution ratio was 2.3:1. The prevalent average age was 55.40 years. About 80% of ulcer site was buccal mucosa then 10 % were lip mucosa. About 80% people were habituated by betel nut, leaf with tobacco chewers. Moreover 46.7% of them were maltreated by quack doctors before. Majority of the patient was in Grade II (56.7%). Correlation between variable in respect of age and cancer grading was explained. According to these study OSCC patients in north bangle region like Bogura was quite high on ( significant p-value ≤ 0.05). Description of oral squamous cell carcinoma on the basis of demographic and clinical profile was the major aim . Most of the cases report with intermediate grade of the disease which often leads to decrease the chance of survival of a patient. So new strategies should be considered to overcome the present situation must be undertaken by oral health programs for the early diagnosis and prevention, build up awareness and management and follow up of oral cancer. Update Dent. Coll. j: 2020; 10 (1): 3-5

scholarly journals Retrospective analysis of Ca cervix postoperative: An institutional study

2016 ◽  
Author(s):  
Chandra Prakash
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Time ◽  
Residual Disease ◽  
Early Stage ◽  
Treatment Length ◽  
Recommended Treatment ◽  
Carcinoma Of Cervix ◽  
Well Differentiated

Introduction: Carcinoma of cervix is one of the leading causes of death worldwide and in developing countries like India. Cervical cancer is third most common cancer among women however there is a good chance of curability if diagnosed in early stage. Materials and Methods: We had analysed 78 patient of carcinoma of cervix post op who were registered from 2012 to 2015 at Dr. Ram Manohar Lohia Institute of Medical Sciences. Results: We analysed 78 patients between age of 32-70 years and median age is 50 year. Among all patients squamous cell carcinoma is most common (65 patient), adenocarcinoma were 12 and lieomyosarcoma was 1 patient. Among all patient 12 were of adenocarcinoma, 1 of lieomyosarcoma and 65 patient of squamous cell carcinoma. On examination 55 patients were NAD and 23 were residual. Among squamous cell carcinoma 35 were moderate differentiated, 18 were well differentiated and 12 were of poorly differentiated. On examination 55 patients were NAD rest were having disease. Gap between EBRT and SORBO ranging from 3 to 99 days and median is 27 days and median is 29 days. Treatment length varies from 4 cm to 8 cm and median is 6 cm. Ovoide size ranges from 2.5 cm to 3.5 cm and median is 2.5 cm. Dose per fraction ranges from 5 Gy to 9 Gy and median was 9 Gy. Median fraction of session were 2. Out of 78 patients 2 were developed metastasis and 6 having residual disease. 28 patients were NAD and rest were referral and send back to parent hospital. Conclusion: Due to lack of resources and awareness of disease maximum number of patient presented with advanced stage. The recommended treatment time could not be achieved due to scarcity of cancer centres, treatment time is prolonged. We have not found any relation between treatment length and outcome. We are still investigating to conclude to found out relation among these variables.

scholarly journals Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

2018 ◽  
Vol 10 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Ethan Frank ◽  
David Macias ◽  
Brian Hondorp ◽  
Justin Kerstetter ◽  
Jared C. Inman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Low Cost ◽  
Neck Mass ◽  
Inclusion Cyst ◽  
Neoplastic Change ◽  
Epidermal Inclusion Cyst ◽  
Hematoxylin And Eosin ◽  
Well Differentiated

Epidermal inclusion cysts are common lesions that rarely develop into squamous cell carcinoma (SCC). Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. This study describes the case of a 64-year-old woman with a 4-year history of a largely asymptomatic neck mass, which after routine excision was found to be an epidermal inclusion cyst harboring well-differentiated SCC. The diagnosis was made incidentally after routine cyst bisection and hematoxylin and eosin staining. Given the potential for variable presentation and low cost of hematoxylin and eosin analysis, we recommend a low threshold for a comprehensive pathological search for malignancy in excised cysts when appropriate.

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