scholarly journals EFFECTIVENESS OF LUMBAR SYMPATHETIC BLOCK IN PATIENTS OF CHRONIC LEG PAIN PRESENTED TO PAIN CLINIC AT A TERTIARY GOVERNMENT HOSPITAL OVER PAST TWO-YEARS: A RETROSPECTIVE AND OBSERVATIONAL STUDY.

2021 ◽  
pp. 18-21
Author(s):  
Vinaya R. Kulkarni ◽  
Madhuri Lokapur
Keyword(s):  
Demographic Data ◽  
Needle Insertion ◽  
Pain Clinic ◽  
Leg Pain ◽  
Walking Distance ◽  
Rest Pain ◽  
Sympathetic Block ◽  
Ct Guided ◽  
Number Of Patients

Background:Lumbar sympathetic block is used in inoperable peripheral vascular disease. The block acts as a vasodilator by decreasing sympathetic tone and improves tissue oxygenation and helps in ulcer healing. No guidelines exist till date for its use in patients with chronic leg pain and ulcers. The management of patients with unreconstructable distal disease with rest pain has always been difficult. Lumbar sympathetic block helps to abolish this rest pain. Aims and Objectives: 1. To study the effectiveness of lumbar sympathetic block 2. To study the ideal level for needle insertion for 100% success rate. 3. To follow up the patients for 1 week, 4 weeks and 12 weeks for relief of symptoms. 4. To study the safety of the block and note the complications. Materials and Methods: After approval of ethical committee, this retrospective study was conducted from Pain Clinic Records over the past two years. Total number of patients studied were 30 over past 2 years. Data Collection: Demographic Data and VAS score was recorded Preblock walking distance was recorded. CT guided lumbar sympathetic block was given. Results and Conclusion: Lumbar sympathetic block was very useful, safe and effective method to decrease the rest pain in patients presented to pain OPD of our hospital. Follow up for 3 months showed healing of ulcers in some of these patients.

scholarly journals Surgical and medical morbidity following failed non-traumatic partial foot amputation in diabetic patients

2017 ◽  
Vol 2 (3) ◽  
pp. 2473011417S0001
Author(s):  
Cole Cheney ◽  
John Femino
Keyword(s):  
Hospital Admissions ◽  
Demographic Data ◽  
Time Frame ◽  
Diabetic Patients ◽  
Index Procedure ◽  
Limb Preservation ◽  
Initial Surgery ◽  
Number Of Patients ◽  
Partial Foot Amputation

Category: Ankle, Diabetes, Lesser Toes, Midfoot/Forefoot Introduction/Purpose: Maximal limb preservation is often the goal in choosing partial foot amputation (PFA) as a treat-ment for diabetic foot infections. Some of these patients will go on to experience multiple hospital admissions, IV antibiotic courses, surgical debridements, re-amputations and other medical compli-cations. This study describes the treatment course of these patients starting at second partial foot amputation and ending at 5 year follow-up. Methods: A retrospective cohort was built from a database of all amputation procedures performed on diabet-ic patients at the University of Iowa Department of Orthopedics from 2000 – 2015. The cohort was evaluated over time frame starting at second PFA (index procedure) and ending at 5 years after in-dex procedure. Of 264 patients who underwent partial foot amputation, 49 experienced two lower extremities PFA between January 2000 and December 2011 (cut-off used to allow minimum of 5 years post-PFA). Demographic data was recorded at index PFA and included surgical dates, laterali-ty, surgery type, diagnoses at time of initial surgery, and death date. A chart review collected in-formation on 5 year post-index PFA incidence of: non-surgical hospitalizations, antibiotic admin-istrations, total contact cast applications, and complications (such as osteomyelitis and acute renal failure). Results: Thirty-two (65%) of the second partial foot amputations (index) were ipsilateral and 17 were con-tralateral to first partial foot amputation (pre-index procedure). Eighteen (37%) of the partial foot amputation patients eventually experienced transtibial / transfemoral amputations in the 5 years fol-lowing index PFA. Eleven (22%) had at least a third partial foot amputation (and as many as 7) dur-ing study period. Sixteen (32%) patients had 17 transtibial / transfemoral amputations within 5 year time frame. 11 of the 17 (65%) TT / TF procedures were ipsilateral to index (second) PFA. Seven (17%) of the patients died. Conclusion: Maximal limb preservation may not be beneficial in all cases, particularly in the case of repeat PFAs. This cohort of repeat PFA patients demonstrated a complicated medical course with long pe-riods of hospitalization, leg immobilization in cast, and home-going antibiotics (requiring PICC). This study suggested that over a 5 year period following second PFA, patients on average experi-enced at least 31 days in TCC, 17 days hospitalized and underwent one additional amputation pro-cedure. These are likely underestimates due to follow-up or outside hospital cares. A large number of patients (18 or 37%) ultimately required higher-level amputation. There is a potential morbidity with PFA that may not be communicated to patients when making these decisions. In this cohort, the average days to second PFA was 360 days. 18 of 49 repeat PFA patients underwent tran-stibial or transfemoral amputation within 5 years of their initial PFA. The morbidity of the interim medical course over 5 years added to the poor quality of life after PFA.

scholarly journals A Staged Treatment of Symptomatic Lumbar Intraspinal Synovial Cysts

2019 ◽  
Vol 5 (22;5) ◽  
pp. E451-E456
Author(s):  
Kyung-Hoon Kim
Keyword(s):  
Minimally Invasive ◽  
Surgical Procedures ◽  
Facet Joint ◽  
University Hospital ◽  
Pain Clinic ◽  
Level Of Evidence ◽  
Endoscopic Surgical Procedures ◽  
Number Of Patients ◽  
Synovial Cysts

Background: Lumbar intraspinal synovial cyst (LISC) refers to a cyst that arises from the zygapophyseal joint capsule of the lumbar spine and contains serous or gelatinous fluid. In cases of LISCs resistant to conservative treatments, various minimally invasive percutaneous spinal techniques (MIPSTs) may be applied prior to open surgery. Objectives: The outcomes of 3-staged MIPSTs for the treatment of symptomatic LISCs resistant to conservative treatments were evaluated. Study Design: An institutional review board approved retrospective chart review. Setting: University hospital inpatients referred to our pain clinic. Methods: Review of charts of all patients who underwent MIPSTs for symptomatic LISCs resistant to conservative treatments during a time period of 13 years at a university hospital pain clinic. Patients with symptomatic LISCs resistant to conservative treatments were treated with 3-staged MIPSTs, including image-guided intraarticular aspiration, cyst distention and rupture, and injection of corticosteroids (ARI), endoscopic cyst enucleation (ECE), and endoscopic superior facetectomy (ESF) by a single pain specialist. A symptom-free period after each intervention was evaluated. Recurrence was defined as the same recurrent symptomatic radicular pain with confirmation of the LISC on magnetic resonance imaging. All patients with a minimum follow-up time of 3 years were included. Results: Of the 40 patients who underwent ARI, 3 patients failed to complete a follow-up and 19 patients (51.4%) who had recurring symptoms received ECE. Ten patients (52.6%) who had rerecurring symptoms after ECE received ESF. There was no recurrence after ESF. Limitations: This retrospective and observational study with a limited number of patients does not represent a high level of evidence. Conclusions: This information provided the recurrence rate after each intervention. Half of the patients who went on to receive ARI experienced recurrence, whereas half of the patients with recurrence who received ECE experienced re-recurrence. ESF treatment resulted in no recurrence within the 3-year study period. Key words: Conservative treatment, endoscopic surgical procedures, facet joint, intraarticular injection, minimally invasive surgical procedures, needle biopsy, nerve root compression, radiculopathy, synovial cysts

Autologous Bone Marrow-Derived Stem Cell Therapy in Patients with Severe Peripheral Arterial Disorders: A Pilot Study.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2877-2877
Author(s):  
Zoltan Boda ◽  
Miklos Udvardy ◽  
Katalin Razso ◽  
Mariann Szarvas ◽  
Katalin Farkas ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Autologous Bone Marrow ◽  
Clinical Results ◽  
Walking Distance ◽  
Rest Pain ◽  
Cd34 Cells ◽  
Autologous Bone ◽  
Peripheral Arterial

Abstract Introduction. Amputation is the only current option for relief of rest pain or gangrene in patients with severe peripheral arterial disease (SPAD). Up to now, no effective blood-flow enhancement therapies are available. Autologous bone marrow-derived stem cell transplantation (ABMSCT) is an arising therapy modality with an option of building new blood vessels through endothelial stem and/or progenitor cells. Methods. Five patients with SPAD (4 with Buerger’s disease and 1 with arteriosclerosis obliterans) were treated by ABMSCT. CD34+/CD133+ cell counts were determined in aspirated bone marrow, CD34+ cells were isolated by magnetic separation and collected into a 10 ml sample. The stem cell suspension was administered by local intramuscular injections (0.5–1.0 ml injections in the musculus gastrocnemius). The follow-up (before; 1−, 3− and 6 months after ABMSCT) based on clinical (rest pain, walking distance without pain, changes of non-healing ulcers, ABI) and laboratory (DS-angiography, Color- and Laser-Doppler scan, TcPO2 measurement and endothel function test) parameters was documented and analyzed. Our goal was to treat the worse limb of all the 5 patients. Results. Therapeutic benefit was shown by complete regression of rest pain in all 5 patients, and by the significant increase of pain-free walking distance (36 m vs. 440 m). Six months after ABMSCT the ischemic ulcers disappeared in 2 patients, and in another 2 patients the large and deep ulcers became smaller and thinner (from 8 cm2 to 2.6 cm2 in one case, and from 30 cm2 to 8 cm2 in another case), and in 1 case no change was realized, where osteomyelitis of the affected toe was diagnosed. The average of ABI improved significantly on the treated lower limb (before: 0.41, 3 and 6 months after: 0.64/0.82). ABI values of the contra-lateral legs did not change. The clinical improvement started 1 months after ABMSCT, it became more prominent after 3 months, and the best clinical results were observed after 6 months of transplantation. Confirmed by post-trial observations obtained at 9 months the clinical improvement was evaluated as stable and long lasting. Using angiography we realized improvement in 3 cases, but only in 1 case using Color-Doppler scan. Before and 6/20 weeks after transplantation the TcPO2 changed on the foot from 18.80/16.78/23.83 mmHg, and on the calf from 36.66/31.25/45.00 mmHg. The laboratory parameters did not show improvement after 1 month, however, after 3 and 6 months improved parameters were recorded. No severe complications, adverse events were detected during the 6 months follow-up period. Conclusions. ABMSCT with isolated CD34+ cells was proved to be safe, effective and resulted in significant and sustained improvement of clinical parameters and quality of life for patients with SPAD. Multicentric, controlled clinical trials are required to confirm these preliminary clinical results.

scholarly journals Computed tomography-guided percutaneous trephine removal of the nidus in osteoid osteoma patients: experience of a single center in Brazil

2015 ◽  
Vol 48 (4) ◽  
pp. 211-215 ◽  
Author(s):  
Marcelo Petrilli ◽  
Andreza Almeida Senerchia ◽  
Antonio Sergio Petrilli ◽  
Henrique Manoel Lederman ◽  
Reynaldo Jesus Garcia Filho
Keyword(s):  
Computed Tomography ◽  
Osteoid Osteoma ◽  
Medical Records ◽  
Demographic Data ◽  
Procedural Pain ◽  
Lesion Site ◽  
Single Center ◽  
Ct Guided ◽  
Patients Experience

Abstract Objective: To report the results of computed tomography (CT)-guided percutaneous resection of the nidus in 18 cases of osteoid osteoma. Materials and Methods: The medical records of 18 cases of osteoid osteoma in children, adolescents and young adults, who underwent CT-guided removal of the nidus between November, 2004 and March, 2009 were reviewed retrospectively for demographic data, lesion site, clinical outcome and complications after procedure. Results: Clinical follow-up was available for all cases at a median of 29 months (range 6–60 months). No persistence of pre-procedural pain was noted on 17 patients. Only one patient experienced recurrence of symptoms 12 months after percutaneous resection, and was successfully retreated by the same technique, resulting in a secondary success rate of 18/18 (100%). Conclusion: CT-guided removal or destruction of the nidus is a safe and effective alternative to surgical resection of the osteoid osteoma nidus.

Retethering of transected fatty filum terminales

2011 ◽  
Vol 7 (1) ◽  
pp. 42-46 ◽  
Author(s):  
Hideki Ogiwara ◽  
Arleta Lyszczarz ◽  
Tord D. Alden ◽  
Robin M. Bowman ◽  
David G. McLone ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Simple Procedure ◽  
Demographic Data ◽  
Rare Condition ◽  
Bladder Capacity ◽  
Leg Pain ◽  
Filum Terminale ◽  
The Mean

Object Untethering of a tethered spinal cord (TSC) by transecting or removing a fatty filum terminale is a relatively simple procedure that can prevent or ameliorate neurological symptoms, and the postoperative prognosis is usually good. Progressive neurological deterioration caused by recurrent tethering has been rarely reported. The authors present their experience in cases in which a sectioned fatty filum terminale has become retethered. Methods The authors retrospectively analyzed the surgical results of pediatric patients with fatty filum terminale–TSC treated by transection of the filum. The patients' charts were reviewed for demographic data, clinical presentation, surgical therapy, and follow-up data. Results Of the 225 children who underwent TSC release by sectioning the fatty filum from 1992 to 2005, there were 6 patients (2.7%; 3 males, 3 females) in whom the fatty filum retethered. The mean age at the first diagnosis of TSC was 5.2 years (range 2 months–12.3 years). The mean duration from the first untethering procedure to retethering was 5.4 years. The mean age at the time of retethering was 10.6 years (range 7–17.5 years). Symptoms of retethering were urinary incontinence, low-back pain, difficulty walking, constipation, leg pain, and worsening foot deformity. Patients underwent cystometrography at the time retethering was indicated by increased bladder capacity, large post-void residual volume, decreased bladder capacity, increase in filling pressure, and poor sensation of filling. Magnetic resonance imaging revealed adherence of the rostral stump of the sectioned filum to the midline dorsal dural surface. All patients underwent the second untethering procedure. Four patients improved neurologically and experienced no retethering thereafter (mean follow-up period 5.5 years). Two patients experienced additional retethering after temporary improvement following the second untethering procedure. Conclusions Retethering of the spinal cord is a rare condition occurring after the sectioning of a fatty filum terminale. Awareness of this rare sequela is necessary for appropriate long-term management of TSC caused by a fatty filum terminale. Cystometrography is useful for detecting the lesion and confirming the diagnosis of retethering.

scholarly journals A Prospective, Nonrandomized, no Placebo-Controlled, Phase I/II Clinical Trial Assessing the Safety and Efficacy of Intramuscular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in Patients with Severe Buerger's Disease

Cell Medicine ◽  
2017 ◽  
Vol 9 (3) ◽  
pp. 87-102 ◽  
Author(s):  
Jeong Chan Ra ◽  
Euicheol C. Jeong ◽  
Sung Keun Kang ◽  
Seog Ju Lee ◽  
Kyoung Ho Choi
Keyword(s):  
Clinical Trial ◽  
Stem Cells ◽  
Intramuscular Injection ◽  
Walking Distance ◽  
Functional Improvement ◽  
Rest Pain ◽  
Buerger’S Disease ◽  
Buerger's Disease ◽  
Pressure Index

Buerger's disease is a rare and severe disease affecting the blood vessels of the limbs. Adipose tissue-derived mesenchymal stem cells (ADSCs) have the potential to cure Buerger's disease when developed as a stem cell drug. In the present study, we conducted a prospective, nonrandomized, no placebo-controlled, phase I/II clinical trial with a 2-year follow-up questionnaire survey. A total of 17 patients were intramuscularly administered autologous ADSCs at a dose of 5 million cells/kg. The incidence of adverse events (AEs), adverse drug reaction (ADR), and serious adverse events (SAEs) was monitored. No ADRs and SAEs related to stem cell treatment occurred during the 6-month follow-up. In terms of efficacy, the primary endpoint was increase in total walking distance (TWD). The secondary endpoint was improvement in rest pain, increase in pain-free walking distance (PFWD), toe–brachial pressure index (TBPI), transcutaneous oxygen pressure (TcPO2), and arterial brachial pressure index (ABPI). ADSCs demonstrated significant functional improvement results including increased TWD, PFWD, and rest pain reduction. No amputations were reported during the 6-month clinical trial period and in the follow-up questionnaire survey more than 2 years after the ADSC injection. In conclusion, intramuscular injection of ADSCs is very safe and is shown to prompt functional improvement in patients with severe Buerger's disease at a dosage of 300 million cells per 60 kg of body weight. However, the confirmatory therapeutic efficacy and angiogenesis need further study.

CT-Guided Posterior Lumbar Interbody Fusion and Distraction

2011 ◽  
Vol 24 (6) ◽  
pp. 919-923 ◽  
Author(s):  
L. Manfré
Keyword(s):  
Interbody Fusion ◽  
Sagittal Plane ◽  
Screw Fixation ◽  
Posterior Lumbar Interbody Fusion ◽  
Pedicle Screw Fixation ◽  
Leg Pain ◽  
Lumbar Interbody Fusion ◽  
Surgical Time ◽  
Ct Guided

We performed CT-guided posterior interbody fusion (PIF) with pedicle screw fixation and distraction to treat degenerative lumbar L4-L5 spondylolisthesis with severe left sciatica. The patient was suffering from L4 nerve root compression related to neural foramina stenosis. The dedicated tools to perform a CT-guided percutaneous PIF technique are described. The procedure was easy to apply with a total surgical time of 90 minutes. The neural foramina were investigated by CT scan reconstruction on sagittal plane demonstrating marked widening after PIF application. The left leg pain completely disappeared in two weeks and the patient remained painless at the three month follow-up control. To our knowledge, there are no other papers on CT-guided PIF procedure in the literature.

Trigeminal neuralgia and neuropathy in large sporadic vestibular schwannomas

2017 ◽  
Vol 127 (5) ◽  
pp. 992-999 ◽  
Author(s):  
Brian A. Neff ◽  
Matthew L. Carlson ◽  
Megan M. O'Byrne ◽  
Jamie J. Van Gompel ◽  
Colin L. W. Driscoll ◽  
...  
Keyword(s):  
Trigeminal Neuralgia ◽  
Treatment Outcomes ◽  
Trigeminal Nerve ◽  
Demographic Data ◽  
Population Data ◽  
Vestibular Schwannomas ◽  
Trigeminal Neuropathy ◽  
Number Of Patients ◽  
Facial Numbness

OBJECTIVEThe aim of this study was to evaluate the incidence, presentation, and treatment outcomes of trigeminal nerve–mediated symptoms secondary to large vestibular schwannomas (VSs) with trigeminal nerve contact. Specifically, the symptomatic results of pain, paresthesias, and numbness after microsurgical resection or stereotactic radiosurgery (SRS) were examined.METHODSThe authors conducted a retrospective review of a database for concomitant diagnosis of trigeminal neuralgia (TN) or trigeminal neuropathy and VS between 1994 and 2014 at a tertiary academic center. All patients with VS with TN or neuropathy were included, with the exception of those patients with neurofibromatosis Type 2 and patients who elected observation. Patient demographic data, symptom evolution, and treatment outcomes were collected. Population data were summarized, and outcome comparisons between microsurgery and SRS were analyzed at last follow-up.RESULTSSixty (2.2%) of 2771 total patients who had large VSs and either TN or neuropathy symptoms met inclusion criteria. The average age of trigeminal symptom onset was 53.6 years (range 24–79 years), the average age at VS diagnosis was 54.4 years (range 25–79 years), and the average follow-up for the microsurgery and SRS groups was 30 and 59 months, respectively (range 3–132 months). Of these patients, 50 (83%) had facial numbness, 16 (27%) had TN pain, and 13 (22%) had paresthesias (i.e., burning or tingling). Subsequently, 50 (83%) patients underwent resection and 10 (17%) patients received SRS.Treatment of VS with SRS did not improve trigeminal symptoms in any patient. This included 2 subjects with unimproved facial numbness and 4 patients with worsened numbness. Similarly, SRS worsened TN pain and paresthesias in 5 patients and failed to improve pain in 2 additional patients. The Barrow Neurological Institute neuralgia and hypesthesia scale scores were significantly worse for patients undergoing SRS compared with microsurgery.Resection alleviated facial numbness in 22 (50%) patients, paresthesias in 5 (42%) patients, and TN in 7 (70%) patients. In several patients, surgery was not successful in relieving facial numbness, which failed to improve in 17 (39%) cases and became worse in 5 (11%) cases. Also, surgery did not change the intensity of facial paresthesias or neuralgia in 6 (50%) and 3 (25%) patients, respectively. Microsurgery exacerbated facial paresthesias in 1 (8%) patient but, notably, did not aggravate TN in any patient.CONCLUSIONSOverall, resection of large VSs provided improved outcomes for patients with concomitant TN, facial paresthesia, and numbness compared with SRS. However, caution should be used when counseling surgical candidates because a number of patients did not experience improvement. This was especially true in patients with preoperative facial numbness and paresthesias, who frequently reported that these symptoms were unchanged following surgery.

Effect of chemotherapy on exercise capacity in patients with advanced non-small cell lung cancer (NSCLC)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 9115-9115
Author(s):  
G. Kasymjanova ◽  
H. Kreisman ◽  
C. Pepe ◽  
L. Lajeunesse ◽  
S. Gagne ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Exercise Capacity ◽  
Drop Out ◽  
Leg Pain ◽  
Walking Distance ◽  
Practice Test ◽  
The Mean ◽  
Clinically Significant ◽  
Intent To Treat

9115 Background: The 6 minute walking distance (6MW) is commonly used to evaluate cardiopulmonary exercise capacity in a variety of patient (pt) populations. Although the 6MW test improved in advanced breast cancer pts who responded to 2 cycles of chemotherapy, (Nieman et al 1995), little is known about exercise capacity of pts with inoperable lung cancer. We prospectively evaluated 6MW in advanced NSCLC pts at diagnosis and following 2 cycles of chemotherapy (CT). Methods: 6MW was performed twice pre (one practice test) and once post 2 cycles of CT. Intent to treat (ITT) analysis was performed in pts who did not complete the last walk. A score of 0 was assigned to those who died and the last observation was carried forward for those with missing data. Results: 59 pts were enrolled though 6 pts withdrew following the practice test due to clinical deterioration (2 pts), pulmonary embolism (1pt), leg pain following the practice walk (1 pt) and withdrawal of consent (2 pts). The mean age of the remaining 53 pts was 61 ±11, PS was 0–1 in 46 (87%) and 2 in 7 (13%) of pts. 8 pts (15%) were stage 3A/3B and 45 (85%) were stage 3B /4 NSCLC. 45 (85%) pts received platinum-based doublets, whereas 8 (15%) had monotherapy. 39 pts completed the study and 14 pts did not complete the second evaluation (4 died, 8 withdrew due to worsening symptoms and 2 were lost for follow-up). The practice 6MW of the 20 pts who dropped out was 361±99 m compared to 448± 93m for the 39 who completed the study (p=0.002). The 6MW decreased from 461±108 m (range 247–748) to 431±98 (range 431–630) in the 39 pts who completed the study (p=0.02) and from 444±106 to 395±107 in the 53 pts using the ITT analysis (p<0.003). There was a clinically significant (>54 m) decrease in 6MW in 11 pts (28%), an increase in 6MW in 2 pts (5%), and no change in 26 (67%) others. The 6MW was higher in men and in pts in stages 3A/B (p<0.05). Conclusions: Exercise capacity, measured by 6MW, declines significantly after two cycles of chemotherapy. This decline may have been underestimated as pts with lower 6MW were more likely to drop out of the study. No significant financial relationships to disclose.

scholarly journals EpidemIBD: rationale and design of a large-scale epidemiological study of inflammatory bowel disease in Spain

2019 ◽  
Vol 12 ◽  
pp. 175628481984703 ◽  
Author(s):  
María Chaparro ◽  
Manuel Barreiro-de Acosta ◽  
José Manuel Benítez ◽  
José Luis Cabriada ◽  
María José Casanova ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Large Scale ◽  
Hospital Admissions ◽  
Financial Burden ◽  
Demographic Data ◽  
Treatment Patterns ◽  
Number Of Patients ◽  
Inflammatory Bowel

Background: Inflammatory bowel disease (IBD) is associated with a considerable burden to the patient and society. However, current data on IBD incidence and burden are limited because of the paucity of nationwide epidemiological studies, heterogeneous designs, and a low number of participating centers and sample size. The EpidemIBD study is a large-scale investigation to provide an accurate assessment of the incidence of IBD in Spain, as well as treatment patterns and outcomes. Methods: This multicenter, population-based incidence cohort study included patients aged >18 years with IBD (Crohn’s disease, ulcerative colitis, or unclassified IBD) diagnosed during 2017 in 108 hospitals in Spain, covering 50% of the Spanish population. Each participating patient will attend 10 clinic visits during 5 years of follow up. Demographic data, IBD characteristics and family history, complications, treatments, surgeries, and hospital admissions will be recorded. Results: The EpidemIBD study is the first large-scale nationwide study to investigate the incidence of IBD in Spain. Enrollment is now completed and 3627 patients are currently being followed up. Conclusions: The study has been designed to overcome many of the limitations of previous European studies into IBD incidence by prospectively recruiting a large number of patients from all regions of Spain. In addition to epidemiological information about the burden of IBD, the 5-year follow-up period will also provide information on treatment patterns, and the natural history and financial burden of IBD.

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