scholarly journals Regenerative medicine: potential applications for foot and ankle disorders

2021 ◽  
Vol 35 (2) ◽  
pp. 117-128
Author(s):  
Francesco Caravaggio ◽  
Michele Antonelli ◽  
Fabio Depalmi
2012 ◽  
Vol 22 (23) ◽  
pp. 11442 ◽  
Author(s):  
Sung-Wook Choi ◽  
Yu Zhang ◽  
Yi-Chun Yeh ◽  
A. Lake Wooten ◽  
Younan Xia

Author(s):  
Emily N. Fatakhov ◽  
Tina Bijlani ◽  
Richard G. Chang

2021 ◽  
Vol 2021 ◽  
pp. 1-20 ◽  
Author(s):  
Dhinakaran Veeman ◽  
M. Swapna Sai ◽  
P. Sureshkumar ◽  
T. Jagadeesha ◽  
L. Natrayan ◽  
...  

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.


2018 ◽  
Vol 11 (2) ◽  
pp. 156-159
Author(s):  
James Cottom ◽  
Scott Carrington ◽  
Stephen A. Brigido ◽  
Stephen A. Brigido ◽  
Minton Truitt Cooper

Nanoscale ◽  
2019 ◽  
Vol 11 (37) ◽  
pp. 17230-17234
Author(s):  
Aijun Li ◽  
Yu Fan ◽  
Xueyan Cao ◽  
Liang Chen ◽  
Le Wang ◽  
...  

Morpholino-functionalized phosphorus dendrimers strongly promote the transformation of mesenchymal stem cells into osteoblasts for potential applications in bone regeneration.


2010 ◽  
Vol 34 (3) ◽  
pp. 238-244 ◽  
Author(s):  
Christopher Morris ◽  
Helen Doll ◽  
Andrew Wainwright ◽  
Neville Davies ◽  
Tim Theologis ◽  
...  

There is increasing recognition of the credibility and utility of patient reported outcome measures, both in research and as routine quality indicators. This paper reviews the development of a questionnaire for children with foot or ankle problems and integrates the findings from three previously published studies in a cohesive way for the orthotic community. The Oxford Ankle Foot Questionnaire for Children was designed to evaluate the effectiveness of interventions. The development process was conducted in three phases. First the items were devised through focus groups with children affected by foot and ankle problems, and their parents. Second, test versions of child and parent questionnaires were evaluated to enable scales to be developed and tested for validity and reliability. Finally, findings from a prospective study assessing how scores changed over time and/or with treatment supported the longitudinal validity and responsiveness of the scales. The questionnaire offers an inexpensive and expedient means to evaluate the effectiveness of orthoses and other interventions used to treat children's foot or ankle problems. The Oxford Ankle Foot Questionnaire for Children has broad utility both in routine clinical settings, or applied research to evaluate treatment programmes and interventions used in paediatric orthopaedics, trauma and rheumatology.


2019 ◽  
Vol 63 (3-4-5) ◽  
pp. 123-130 ◽  
Author(s):  
Marta Czernik ◽  
Debora A. Anzalone ◽  
Luca Palazzese ◽  
Mami Oikawa ◽  
Pasqualino Loi

Somatic cell nuclear transfer (SCNT) has a broad spectrum of potential applications, including rescue of endangered species, production of transgenic animals, drug production, and regenerative medicine. Unfortunately, the efficiency of SCNT is still disappointingly low. Many factors affecting cloning procedures have been described in several previous reviews; here we review the most effective improvements in SCNT, with a special emphasis on the effect of mitochondrial defects on SCNT embryo/ foetus development, an issue never touched upon before.


2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Adriana Bos-Mikich ◽  
Fabiana F. Bressan ◽  
Rafael R. Ruggeri ◽  
Yeda Watanabe ◽  
Flávio V. Meirelles

Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. Different activating methods have been tested on human and nonhuman oocytes, with varying degrees of success in terms of parthenote generation rates, embryo development stem cell derivation rates. Success in achieving a standardized artificial activation methodology for human oocytes and the subsequent potential therapeutic gain obtained from these embryos depends mainly on the availability of gametes donated from infertility treatments. This review will focus on the creation of parthenotes from clinically unusable oocytes for derivation and establishment of human parthenogenetic stem cell lines and their potential applications in regenerative medicine.


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