scholarly journals Advanced Characterisation of a Sensor System for Droplet-Based Microfluidics

2021 ◽  
Author(s):  
Max Bartunik ◽  
Marco Fleischer ◽  
Werner Haselmayr ◽  
Jens Kirchner
Keyword(s):  
Video Processing ◽  
Data Transmission ◽  
High Specificity ◽  
Microfluidic Chips ◽  
Submillimeter Range ◽  
Individual Values ◽  
Lab On Chip ◽  
Depth Analysis ◽  
Droplet Sizes ◽  
On Chip

Droplet-based microfluidics show a large potential for lab-on-chip applications and new data transmission scenarios. Microfluidic chips contain channels in the submillimeter range allowing for flow of droplets. In a previous contribution, a new sensor design for droplet size and colour detection, consisting of an infrared and a colour sensor, was presented and a first proof-of-concept was shown. In this work, an in-depth analysis of both concepts is presented. In particular, we show that a high precision can be achieved when using the sensor to measure droplet sizes while using video processing software as reference. Furthermore, a colour alphabet consisting of 126 individual values is transmitted and detected using a machine learning model. The high specificity of achieved colour measurement allows both for colour coded data transmission scenarios and the analysis of colour reagents in lab-on-chip applications.

scholarly journals Advanced Characterisation of a Sensor System for Droplet-Based Microfluidics

2021 ◽  
Author(s):  
Max Bartunik ◽  
Marco Fleischer ◽  
Werner Haselmayr ◽  
Jens Kirchner
Keyword(s):  
Video Processing ◽  
Data Transmission ◽  
High Specificity ◽  
Microfluidic Chips ◽  
Submillimeter Range ◽  
Individual Values ◽  
Lab On Chip ◽  
Depth Analysis ◽  
Droplet Sizes ◽  
On Chip

Droplet-based microfluidics show a large potential for lab-on-chip applications and new data transmission scenarios. Microfluidic chips contain channels in the submillimeter range allowing for flow of droplets. In a previous contribution, a new sensor design for droplet size and colour detection, consisting of an infrared and a colour sensor, was presented and a first proof-of-concept was shown. In this work, an in-depth analysis of both concepts is presented. In particular, we show that a high precision can be achieved when using the sensor to measure droplet sizes while using video processing software as reference. Furthermore, a colour alphabet consisting of 126 individual values is transmitted and detected using a machine learning model. The high specificity of achieved colour measurement allows both for colour coded data transmission scenarios and the analysis of colour reagents in lab-on-chip applications.

scholarly journals The Fusion of Microfluidics and Optics for On-Chip Detection and Characterization of Microalgae

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1137
Author(s):  
Xinqi Zheng ◽  
Xiudong Duan ◽  
Xin Tu ◽  
Shulan Jiang ◽  
Chaolong Song
Keyword(s):  
Fossil Fuels ◽  
High Specificity ◽  
Microfluidic Chips ◽  
Optical Components ◽  
Lab On Chip ◽  
Metabolic Heterogeneity ◽  
On Chip ◽  
Micro Systems

It has been demonstrated that microalgae play an important role in the food, agriculture and medicine industries. Additionally, the identification and counting of the microalgae are also a critical step in evaluating water quality, and some lipid-rich microalgae species even have the potential to be an alternative to fossil fuels. However, current technologies for the detection and analysis of microalgae are costly, labor-intensive, time-consuming and throughput limited. In the past few years, microfluidic chips integrating optical components have emerged as powerful tools that can be used for the analysis of microalgae with high specificity, sensitivity and throughput. In this paper, we review recent optofluidic lab-on-chip systems and techniques used for microalgal detection and characterization. We introduce three optofluidic technologies that are based on fluorescence, Raman spectroscopy and imaging-based flow cytometry, each of which can achieve the determination of cell viability, lipid content, metabolic heterogeneity and counting. We analyze and summarize the merits and drawbacks of these micro-systems and conclude the direction of the future development of the optofluidic platforms applied in microalgal research.

scholarly journals Micro–Macro: Selective Integration of Microfeatures Inside Low-Cost Macromolds for PDMS Microfluidics Fabrication

Micromachines ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 576 ◽  
Author(s):  
Edgar Jiménez-Díaz ◽  
Mariel Cano-Jorge ◽  
Diego Zamarrón-Hernández ◽  
Lucia Cabriales ◽  
Francisco Páez-Larios ◽  
...  
Keyword(s):  
Soft Lithography ◽  
Low Cost ◽  
Cost Effective ◽  
Microfluidic Chips ◽  
Single Chip ◽  
Lab On Chip ◽  
Molding Method ◽  
On Chip ◽  
Selective Integration ◽  
Important Progress

Microfluidics has become a very promising technology in recent years, due to its great potential to revolutionize life-science solutions. Generic microfabrication processes have been progressively made available to academic laboratories thanks to cost-effective soft-lithography techniques and enabled important progress in applications like lab-on-chip platforms using rapid- prototyping. However, micron-sized features are required in most designs, especially in biomimetic cell culture platforms, imposing elevated costs of production associated with lithography and limiting the use of such devices. In most cases, however, only a small portion of the structures require high-resolution and cost may be decreased. In this work, we present a replica-molding method separating the fabrication steps of low (macro) and high (micro) resolutions and then merging the two scales in a single chip. The method consists of fabricating the largest possible area in inexpensive macromolds using simple techniques such as plastics micromilling, laser microfabrication, or even by shrinking printed polystyrene sheets. The microfeatures were made on a separated mold or onto existing macromolds using photolithography or 2-photon lithography. By limiting the expensive area to the essential, the time and cost of fabrication can be reduced. Polydimethylsiloxane (PDMS) microfluidic chips were successfully fabricated from the constructed molds and tested to validate our micro–macro method.

scholarly journals A Lab‐On‐chip Tool for Rapid, Quantitative, and Stage‐selective Diagnosis of Malaria

2021 ◽  
pp. 2004101
Author(s):  
Marco Giacometti ◽  
Francesca Milesi ◽  
Pietro Lorenzo Coppadoro ◽  
Alberto Rizzo ◽  
Federico Fagiani ◽  
...  
Keyword(s):  
Lab On Chip ◽  
On Chip

scholarly journals Integrated Magnetohydrodynamic Pump with Magnetic Composite Substrate and Laser-Induced Graphene Electrodes

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1113
Author(s):  
Mohammed Asadullah Khan ◽  
Jürgen Kosel
Keyword(s):  
Magnetic Flux ◽  
Flow Rate ◽  
Magnetic Composite ◽  
Propulsive Force ◽  
Closed Channel ◽  
Lab On Chip ◽  
Composite Substrate ◽  
On Chip ◽  
High Level ◽  
Moving Parts

An integrated polymer-based magnetohydrodynamic (MHD) pump that can actuate saline fluids in closed-channel devices is presented. MHD pumps are attractive for lab-on-chip applications, due to their ability to provide high propulsive force without any moving parts. Unlike other MHD devices, a high level of integration is demonstrated by incorporating both laser-induced graphene (LIG) electrodes as well as a NdFeB magnetic-flux source in the NdFeB-polydimethylsiloxane permanent magnetic composite substrate. The effects of transferring the LIG film from polyimide to the magnetic composite substrate were studied. Operation of the integrated magneto hydrodynamic pump without disruptive bubbles was achieved. In the studied case, the pump produces a flow rate of 28.1 µL/min. while consuming ~1 mW power.

scholarly journals Towards lab-on-chip ultrasensitive ethanol detection using photonic crystal waveguide operating in the mid infrared

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ali Rostamian ◽  
Ehsan Madadi-Kandjani ◽  
Hamed Dalir ◽  
Volker J. Sorger ◽  
Ray T. Chen
Keyword(s):  
Photonic Crystal ◽  
Slow Light ◽  
High Sensitivity ◽  
Guided Wave ◽  
Silicon On Insulator ◽  
Group Index ◽  
Photonic Crystal Waveguide ◽  
Mid Infrared ◽  
Lab On Chip ◽  
On Chip

Abstract Thanks to the unique molecular fingerprints in the mid-infrared spectral region, absorption spectroscopy in this regime has attracted widespread attention in recent years. Contrary to commercially available infrared spectrometers, which are limited by being bulky and cost-intensive, laboratory-on-chip infrared spectrometers can offer sensor advancements including raw sensing performance in addition to use such as enhanced portability. Several platforms have been proposed in the past for on-chip ethanol detection. However, selective sensing with high sensitivity at room temperature has remained a challenge. Here, we experimentally demonstrate an on-chip ethyl alcohol sensor based on a holey photonic crystal waveguide on silicon on insulator-based photonics sensing platform offering an enhanced photoabsorption thus improving sensitivity. This is achieved by designing and engineering an optical slow-light mode with a high group-index of n g  = 73 and a strong localization of modal power in analyte, enabled by the photonic crystal waveguide structure. This approach includes a codesign paradigm that uniquely features an increased effective path length traversed by the guided wave through the to-be-sensed gas analyte. This PIC-based lab-on-chip sensor is exemplary, spectrally designed to operate at the center wavelength of 3.4 μm to match the peak absorbance for ethanol. However, the slow-light enhancement concept is universal offering to cover a wide design-window and spectral ranges towards sensing a plurality of gas species. Using the holey photonic crystal waveguide, we demonstrate the capability of achieving parts per billion levels of gas detection precision. High sensitivity combined with tailorable spectral range along with a compact form-factor enables a new class of portable photonic sensor platforms when combined with integrated with quantum cascade laser and detectors.

Monitoring microbial growth on a microfluidic lab-on-chip with electrochemical impedance spectroscopic technique

2021 ◽  
Vol 23 (2) ◽  
Author(s):  
Subhan Shaik ◽  
Aarthi Saminathan ◽  
Deepak Sharma ◽  
Jagdish A Krishnaswamy ◽  
D Roy Mahapatra
Keyword(s):  
Microbial Growth ◽  
Electrochemical Impedance ◽  
Spectroscopic Technique ◽  
Lab On Chip ◽  
On Chip ◽  
Electrochemical Impedance Spectroscopic

scholarly journals Design Methodology of Passive In-Line Relays for Molecular Communication in Flow-Induced Microfluidic Channel

Biosensors ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 65
Author(s):  
Puneet Manocha ◽  
Gitanjali Chandwani
Keyword(s):  
Communication System ◽  
Communication Systems ◽  
Microfluidic Channel ◽  
Microfluidic Channels ◽  
Molecular Communication ◽  
External Energy ◽  
Lab On Chip ◽  
Molecular Communication Systems ◽  
Macro Scale ◽  
On Chip

Molecular communication is a bioinspired communication that enables macro-scale, micro-scale and nano-scale devices to communicate with each other. The molecular communication system is prone to severe signal attenuation, dispersion and delay, which leads to performance degradation as the distance between two communicating devices increases. To mitigate these challenges, relays are used to establish reliable communication in microfluidic channels. Relay assisted molecular communication systems can also enable interconnection among various entities of the lab-on-chip for sharing information. Various relaying schemes have been proposed for reliable molecular communication systems, most of which lack practical feasibility. Thus, it is essential to design and develop relays that can be practically incorporated into the microfluidic channel. This paper presents a novel design of passive in-line relay for molecular communication system that can be easily embedded in the microfluidic channel and operate without external energy. Results show that geometric modification in the microfluidic channel can act as a relay and restore the degraded signal up-to 28%.

scholarly journals Diagnosis of Malaria: A Lab‐On‐chip Tool for Rapid, Quantitative, and Stage‐selective Diagnosis of Malaria (Adv. Sci. 14/2021)

2021 ◽  
Vol 8 (14) ◽  
pp. 2170087
Author(s):  
Marco Giacometti ◽  
Francesca Milesi ◽  
Pietro Lorenzo Coppadoro ◽  
Alberto Rizzo ◽  
Federico Fagiani ◽  
...  
Keyword(s):  
Lab On Chip ◽  
On Chip
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