A Dense Magnetic Coil Array with Multi-locus and Multi-site Patterning

2021 ◽  
Author(s):  
Matthew Smith ◽  
Daniel Sievenpiper
Keyword(s):  
Drug Delivery ◽  
Membrane Disruption ◽  
Coil Array ◽  
Tumor Cell Membrane ◽  
Magnetic Coil ◽  
Magnetic Drug Delivery ◽  
Higher Power ◽  
Cell Membrane Disruption ◽  
Noninvasive Neuromodulation ◽  
Relevant Range

<p>· We propose multi-loci and multi-site current patterning (sequential or simultaneous) for precise, rapid and repeatable steering for improved neuronal targeting.</p><p>· Here we demonstrate these improvements by using a unique pixel cell for excitation synthesis as enabled by a three-layer dense magnetic coil array that is mapped to a hexagonal grid with cubic coordinates.</p><p>· We validate the theory with supporting simulations, experimental results and a scalable electronics design that can address a relevant range of larger coil diameters, higher power levels and topologies.</p><p><a></a></p><p>· Precise, rapid and repeatable patterns potentially offer new modalities for noninvasive neuromodulation (suprathreshold and subthreshold) and adjacent biomagnetic applications such as tumor cell membrane disruption [1], and magnetic drug delivery [2].</p>

scholarly journals A Dense Magnetic Coil Array with Multi-locus and Multi-site Patterning

2021 ◽  
Author(s):  
Matthew Smith ◽  
Daniel Sievenpiper
Keyword(s):  
Drug Delivery ◽  
Membrane Disruption ◽  
Coil Array ◽  
Tumor Cell Membrane ◽  
Magnetic Coil ◽  
Magnetic Drug Delivery ◽  
Higher Power ◽  
Cell Membrane Disruption ◽  
Noninvasive Neuromodulation ◽  
Relevant Range

<p>· We propose multi-loci and multi-site current patterning (sequential or simultaneous) for precise, rapid and repeatable steering for improved neuronal targeting.</p><p>· Here we demonstrate these improvements by using a unique pixel cell for excitation synthesis as enabled by a three-layer dense magnetic coil array that is mapped to a hexagonal grid with cubic coordinates.</p><p>· We validate the theory with supporting simulations, experimental results and a scalable electronics design that can address a relevant range of larger coil diameters, higher power levels and topologies.</p><p><a></a></p><p>· Precise, rapid and repeatable patterns potentially offer new modalities for noninvasive neuromodulation (suprathreshold and subthreshold) and adjacent biomagnetic applications such as tumor cell membrane disruption [1], and magnetic drug delivery [2].</p>

scholarly journals Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 444
Author(s):  
Motoharu Hirano ◽  
Chihiro Saito ◽  
Hidetomo Yokoo ◽  
Chihiro Goto ◽  
Ryuji Kawano ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Hemolytic Activity ◽  
Helical Structure ◽  
Antimicrobial Activities ◽  
Side Chain ◽  
Membrane Disruption ◽  
Amino Acid Residues ◽  
Electrophysiological Measurements ◽  
Cell Membrane Disruption

Magainin 2 (Mag2), which was isolated from the skin of the African clawed frog, is a representative antimicrobial peptide (AMP) that exerts antimicrobial activity via microbial membrane disruption. It has been reported that the helicity and amphipathicity of Mag2 play important roles in its antimicrobial activity. We investigated and recently reported that 17 amino acid residues of Mag2 are required for its antimicrobial activity, and accordingly developed antimicrobial foldamers containing α,α-disubstituted amino acid residues. In this study, we further designed and synthesized a set of Mag2 derivatives bearing the hydrocarbon stapling side chain for helix stabilization. The preferred secondary structures, antimicrobial activities, and cell-membrane disruption activities of the synthesized peptides were evaluated. Our analyses revealed that hydrocarbon stapling strongly stabilized the helical structure of the peptides and enhanced their antimicrobial activity. Moreover, peptide 2 stapling between the first and fifth position from the N-terminus showed higher antimicrobial activity than that of Mag2 against both gram-positive and gram-negative bacteria without exerting significant hemolytic activity. To investigate the modes of action of tested peptides 2 and 8 in antimicrobial and hemolytic activity, electrophysiological measurements were performed.

scholarly journals Magnetic Drug Delivery: Where the Field Is Going

2018 ◽  
Vol 6 ◽  
Author(s):  
Paige M. Price ◽  
Waleed E. Mahmoud ◽  
Ahmed A. Al-Ghamdi ◽  
Lyudmila M. Bronstein
Keyword(s):  
Drug Delivery ◽  
Magnetic Drug Delivery

scholarly journals Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

2020 ◽  
Author(s):  
Matteo Bruno Lodi ◽  
Alessandro Fanti
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Heat Dissipation ◽  
Hyperthermia Treatment ◽  
Prosthetic Implants ◽  
Magnetic Carriers ◽  
Magnetic Drug Delivery ◽  
Influence Parameter ◽  
Nonlinear Nature

The combination of magnetic nanoparticles and a biocompatible material leads to the manufacturing of a multifunctional and remotely controlled platform useful for diverse biomedical issues. If a static magnetic field is applied, a magnetic scaffold behaves like an attraction platform for magnetic carriers of growth factors, thus being a potential tool to enhance magnetic drug delivery in regenerative medicine. To translate in practice this potential application, a careful and critical description of the physics and the influence parameter is required. This chapter covers the mathematical modeling of the process and assesses the problem of establishing the influence of the drug delivery system on tissue regeneration. On the other hand, if a time-varying magnetic field is applied, the magnetic nanoparticles would dissipate heat, which can be exploited to perform local hyperthermia treatment on residual cancer cells in the bone tissue. To perform the treatment planning, it is necessary to account for the modeling of the intrinsic nonlinear nature of the heat dissipation dynamic in magnetic prosthetic implants. In this work, numeric experiments to investigate the physiopathological features of the biological system, linked to the properties of the nanocomposite magnetic material, to assess its effectiveness as therapeutic agents are presented.

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