scholarly journals Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

2020 ◽  
Author(s):  
Matteo Bruno Lodi ◽  
Alessandro Fanti
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Heat Dissipation ◽  
Hyperthermia Treatment ◽  
Prosthetic Implants ◽  
Magnetic Carriers ◽  
Magnetic Drug Delivery ◽  
Influence Parameter ◽  
Nonlinear Nature

The combination of magnetic nanoparticles and a biocompatible material leads to the manufacturing of a multifunctional and remotely controlled platform useful for diverse biomedical issues. If a static magnetic field is applied, a magnetic scaffold behaves like an attraction platform for magnetic carriers of growth factors, thus being a potential tool to enhance magnetic drug delivery in regenerative medicine. To translate in practice this potential application, a careful and critical description of the physics and the influence parameter is required. This chapter covers the mathematical modeling of the process and assesses the problem of establishing the influence of the drug delivery system on tissue regeneration. On the other hand, if a time-varying magnetic field is applied, the magnetic nanoparticles would dissipate heat, which can be exploited to perform local hyperthermia treatment on residual cancer cells in the bone tissue. To perform the treatment planning, it is necessary to account for the modeling of the intrinsic nonlinear nature of the heat dissipation dynamic in magnetic prosthetic implants. In this work, numeric experiments to investigate the physiopathological features of the biological system, linked to the properties of the nanocomposite magnetic material, to assess its effectiveness as therapeutic agents are presented.

Phase-change material filled hollow magnetic nanoparticles for cancer therapy and dual modal bioimaging

Nanoscale ◽  
2015 ◽  
Vol 7 (19) ◽  
pp. 9004-9012 ◽  
Author(s):  
Jinghua Li ◽  
Yan Hu ◽  
Yanhua Hou ◽  
Xinkun Shen ◽  
Gaoqiang Xu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Phase Change ◽  
Phase Change Material ◽  
Alternating Magnetic Field ◽  
Change Material

An alternating magnetic field triggered nanocarrier for drug delivery is fabricated for dual modal imaging-guided thermo-chemo cancer therapy.

scholarly journals Biodegradable Magnetic Nanocomposite Spheres Fabrication by O∕O Emulsion∕Solvent Evaporation Technique for Drug Delivery Purposes

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
R. Asmatulu ◽  
A. Fakhari
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Uv Light ◽  
Solvent Evaporation ◽  
Ferrous Chloride ◽  
Strong Base ◽  
Nanocomposite Particles ◽  
Pump Speed ◽  
Evaporation Technique

Drug targeting systems are important research areas for many diseases treatments (e.g., cancer, nerve damage, heart and artery, diabetic, eye and other medical treatments). Currently, magnetic field, electric field, ultrasound, temperature, UV light and∕or mechanical force systems are considered more for research and development. Magnetic targeted drug delivery system is usually preferred because targeted systems improve the therapeutic index of drug molecules by minimizing the toxic side effects on healthy cells and tissues. In this study, magnetic nanoparticles (∼10nm) were prepared by a chemical coprecipitation of ferric and ferrous chloride salts in the presence of a strong base (ammonium hydroxide) and used for a drug delivery purposes. An oil-in-oil emulsion∕solvent evaporation technique was chosen for the synthesis of nanocomposite spheres. Percentages of magnetic nanoparticles (%5, %10, %20 and%30) and poly(D,L-lactide-co-glycolide) were combined together to produce nanocomposite particles with diameters of 500nmto1.2micronmeter. The effect of particle concentrations on nanocomposite particle size and distribution and morphology were investigated by using scanning electron microscopy (SEM) and laser light scattering (LLS). Additionally, external magnetic fields with various magnet distance, magnetic field, pump speed and solid contents were applied to the nanocomposite particles in a liquid media to find out the effect of variables for the targeting of drug carrying nanocomposite spheres.

scholarly journals Bio-Catalysis and Biomedical Perspectives of Magnetic Nanoparticles as Versatile Carriers

2019 ◽  
Vol 5 (3) ◽  
pp. 42 ◽  
Author(s):  
Muhammad Bilal ◽  
Shahid Mehmood ◽  
Tahir Rasheed ◽  
Hafiz M. N. Iqbal
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Molecular Level ◽  
State Of The Art ◽  
Volume Ratio ◽  
Controlled Drug Delivery ◽  
High Mass ◽  
Biological Interactions ◽  
Magnetic Carriers

In recent years, magnetic nanoparticles (MNPs) have gained increasing attention as versatile carriers because of their unique magnetic properties, biocatalytic functionalities, and capabilities to work at the cellular and molecular level of biological interactions. Moreover, owing to their exceptional functional properties, such as large surface area, large surface-to-volume ratio, and mobility and high mass transference, MNPs have been employed in several applications in different sectors such as supporting matrices for enzymes immobilization and controlled release of drugs in biomedicine. Unlike non-magnetic carriers, MNPs can be easily separated and recovered using an external magnetic field. In addition to their biocompatible microenvironment, the application of MNPs represents a remarkable green chemistry approach. Herein, we focused on state-of-the-art two majorly studied perspectives of MNPs as versatile carriers for (1) matrices for enzymes immobilization, and (2) matrices for controlled drug delivery. Specifically, from the applied perspectives of magnetic nanoparticles, a series of different applications with suitable examples are discussed in detail. The second half is focused on different metal-based magnetic nanoparticles and their exploitation for biomedical purposes.

scholarly journals Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

Polymers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 1832 ◽  
Author(s):  
Ylenia Jabalera ◽  
Francesca Oltolina ◽  
Ana Peigneux ◽  
Alberto Sola-Leyva ◽  
Maria P. Carrasco-Jiménez ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Targeted Drug Delivery ◽  
Magnetic Hyperthermia ◽  
Simultaneous Application ◽  
Biomimetic Nanoparticles ◽  
Targeted Drug ◽  
Model Drug ◽  
Drug Nanocarriers

The design of novel nanomaterials that can be used as multifunctional platforms allowing the combination of therapies is gaining increased interest. Moreover, if this nanomaterial is intended for a targeted drug delivery, the use of several guidance methods to increase guidance efficiency is also crucial. Magnetic nanoparticles (MNPs) allow this combination of therapies and guidance strategies. In fact, MNPs can be used simultaneously as drug nanocarriers and magnetic hyperthermia agents and, moreover, they can be guided toward the target by an external magnetic field and by their functionalization with a specific probe. However, it is difficult to find a system based on MNPs that exhibits optimal conditions as a drug nanocarrier and as a magnetic hyperthermia agent. In this work, a novel nanoformulation is proposed to be used as a multifunctional platform that also allows dual complementary guidance. This nanoformulation is based on mixtures of inorganic magnetic nanoparticles (M) that have been shown to be optimal hyperthermia agents, and biomimetic magnetic nanoparticles (BM), that have been shown to be highly efficient drug nanocarriers. The presence of the magnetosome protein MamC at the surface of BM confers novel surface properties that allow for the efficient and stable functionalization of these nanoparticles without the need of further coating, with the release of the relevant molecule being pH-dependent, improved by magnetic hyperthermia. The BM are functionalized with Doxorubicin (DOXO) as a model drug and with an antibody that allows for dual guidance based on a magnetic field and on an antibody. The present study represents a proof of concept to optimize the nanoformulation composition in order to provide the best performance in terms of the magnetic hyperthermia agent and drug nanocarrier.

Targeting Magnetic Nanoparticles in High Magnetic Fields for Drug Delivery Purposes

2004 ◽  
Vol 820 ◽  
Author(s):  
Ramazan Asmatulu ◽  
Richard.O. Claus ◽  
Judy S. Riffle ◽  
Michael Zalich
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Magnetic Particles ◽  
Guidance System ◽  
Test Results ◽  
Test Parameters ◽  
Magnetic Guidance ◽  
The Magnetic Field

AbstractBiodegradable magnetic nanoparticles were synthesized using Poly(L-Lactic Acid) and magnetite nanoparticles (∼14 nm) at different dosages, and then these nanaoparticles (nanocomposites) and pure magnetic particles were targeted in external magnetic fields by changing the test parameters. The magnetic field test results showed that magnetic saturation, fluid speed, magnetic field distance and particle size were extremely effective for a magnetic guidance system that is needed for an effective drug delivery approach. Thus, it is assumed that such nanoparticles can carry drugs (chemotherapy) to be able to cure cancer tumors as well as many other diseases.

Radioiodination of cyclin dependent kinase inhibitor Olomoucine loaded Fe@Au nanoparticle and evaluation of the therapeutic efficacy on cancerous cells

2017 ◽  
Vol 105 (3) ◽  
Author(s):  
Gokhan Takan ◽  
Ozge Kozgus Guldu ◽  
Emin Ilker Medine
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Au Nanoparticles ◽  
Kinase Inhibitor ◽  
Au Nanoparticle ◽  
Target Tissue ◽  
Cyclin Dependent Kinase Inhibitor ◽  
Magnetic Drug Delivery ◽  
Cancerous Cells

AbstractMagnetic nanoparticles have promising biomedical applications such as drug delivery, novel therapeutics and diagnostic imaging. Magnetic drug delivery combination works on the delivery of magnetic nanoparticles loaded with drug to the target tissue by means of an external magnetic field. Gold coated iron oxide (Fe@Au) nanoparticles can provide useful surface chemistry and biological reactivity. Covalent conjugation to the Fe@Au nanoparticles through cleavable linkages can be used to deliver drugs to tumor cells, then the drug can be released by an external. In this paper, purine based cyclin dependent kinases (CDKs) inhibitor Olomoucine (Olo) [2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine] was loaded on gold coated iron oxide (Fe@Au) nanoparticles and radiolabeled with

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