scholarly journals SIGNIFICANCE OF LACTATE ESTIMATION IN DEBILITATED MYOPATHIES AND TREATMENT PROGRAMS Lactate levels in myopathies

2013 ◽  
Vol 2 (1) ◽  
pp. 3-5
Author(s):  
Junaid Mahmood Alam ◽  
Sumaira Imran Farooqui ◽  
Amna Hussain ◽  
Syed Riaz Mahmood ◽  
Suad Naheed ◽  
...  
Keyword(s):  
Physical Therapy ◽  
Aerobic Capacity ◽  
Aerobic Training ◽  
Lactate Concentration ◽  
Muscle Metabolism ◽  
Treatment Programs ◽  
Gradual Decline ◽  
Muscle Strengthening ◽  
Strengthening Exercises ◽  
Lactate Levels

BACKGROUND Metabolic alteration such as acidosis and abnormally high levels of lactate productions are responsible for development of disabilities in polymyositis and dermatomyositis. Interestingly, this has been suggested that by proper aerobic training, combined with muscle strengthening exercises, shows improve aerobic capacity and muscle metabolism. AIM AND OBJECTIVES The present study was undertaken to evaluate lactate concentrations in myopathy patients and determines the efficacy of exercise therapy in improving aerobic status of such patients. MATERIALS AND METHODS Selected myopathy patients grouped as PM (n = 12 patients) and DM (n = 8 patients). The effects of physical therapy treatments were assessed by lactate estimation at zero, 15th and 28th days. RESULTS Gradual decline in lactate concentration was noted in both PM and DM group, however more prominently in later than in former. The total decline in lactate levels from zero days to 28th day was 42% for PM patients and a considerable 63% for DM patients. CONCLUSION It was suggested that estimation of lactate levels in PM and DM patients is of some metabolic importance and physiotherapy treatments did cause improvement in aerobic efficiency of muscles, which was depicted by periodic decline in lactate concentration after 15 and 28 days.

Strength training in children and adolescents: science, effects and recommandations

2017 ◽  
Vol 65 (3) ◽  
Keyword(s):  
Strength Training ◽  
Children And Adolescents ◽  
International Health ◽  
Well Being ◽  
Review Article ◽  
Physical Activity Guidelines ◽  
Muscle Strengthening ◽  
Strengthening Exercises ◽  
Methodological Aspects ◽  
Practical Recommendations

During the last years, muscle strengthening exercises have been included as an essential part in youth physical activity guidelines of national and international health organisations. It is well-documented that strength training is effective in improving physical fitness and promoting health and psycho-social well-being. Therefore, the purpose of this review article is to present empirical evidence on the effectiveness of strength training in children and adolescents. Additionally, and with reference to an established youth physical development model, conceptual and methodological aspects of safe and effective strength training in youth will be discussed and specific practical recommendations will be presented.

Blood lactate concentration in COVID-19: a systematic literature review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Giovanni Carpenè ◽  
Diletta Onorato ◽  
Riccardo Nocini ◽  
Gianmarco Fortunato ◽  
John G. Rizk ◽  
...  
Keyword(s):  
Literature Review ◽  
Blood Lactate ◽  
Systematic Literature Review ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Organ Injury ◽  
Respiratory Condition ◽  
Therapeutic Decisions ◽  
Lactate Levels ◽  
Elevated Lactate

Abstract Coronavirus disease 2019 (COVID-19) is an infectious respiratory condition sustained by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which manifests prevalently as mild to moderate respiratory tract infection. Nevertheless, in a number of cases the clinical course may deteriorate, with onset of end organ injury, systemic dysfunction, thrombosis and ischemia. Given the clinical picture, baseline assessment and serial monitoring of blood lactate concentration may be conceivably useful in COVID-19. We hence performed a systematic literature review to explore the possible association between increased blood lactate levels, disease severity and mortality in COVID-19 patients, including comparison of lactate values between COVID-19 and non-COVID-19 patients. We carried out an electronic search in Medline and Scopus, using the keywords “COVID-19” OR “SARS-CoV-2” AND “lactate” OR “lactic acid” OR “hyperlactatemia”, between 2019 and present time (i.e. October 10, 2021), which allowed to identify 19 studies, totalling 6,459 patients. Overall, we found that COVID-19 patients with worse outcome tend to display higher lactate values than those with better outcome, although most COVID-19 patients in the studies included in our analysis did not have sustained baseline hyperlactatemia. Substantially elevated lactate values were neither consistently present in all COVID-19 patients who developed unfavourable clinical outcomes. These findings suggest that blood lactate monitoring upon admission and throughout hospitalization may be useful for early identification of higher risk of unfavourable COVID-19 illness progression, though therapeutic decisions based on using conventional hyperlactatemia cut-off values (i.e., 2.0 mmol/L) upon first evaluation may be inappropriate in patients with SARS-CoV-2 infection.

The use of balance training in elderly people with falls

2003 ◽  
Vol 13 (2) ◽  
pp. 153-161 ◽  
Author(s):  
PW Overstall
Keyword(s):  
Elderly People ◽  
Social Factors ◽  
Balance Training ◽  
Occupational Therapist ◽  
Home Modification ◽  
Muscle Strengthening ◽  
Strengthening Exercises ◽  
Multi Disciplinary Team ◽  
Multiple Interventions

Falls, once thought to be an inevitable consequence of aging are now known to be the result of multiple pathological, psychological and social factors. Moreover, well-conducted research has shown that they can be prevented. Initially it appeared that multiple interventions by a multi-disciplinary team would be the most sensible and indeed the only effective approach. However, single interventions may sometimes be appropriate and on cost grounds would be preferable, provided that they are effective. This is clearly the case in the use of pacemakers for patients who are falling because of cardioinhibitory syncope. However, home modification, a seemingly obvious and intuitively correct intervention, has not been shown to prevent falls, although advice from an experienced occupational therapist can reduce falls, especially in those who have fallen previously. Whether balance training on its own is effective in reducing falls, or needs to be combined with muscle-strengthening exercises and other interventions, will be examined.

Disposal of blood [1-13C]lactate in humans during rest and exercise

1986 ◽  
Vol 60 (1) ◽  
pp. 232-241 ◽  
Author(s):  
R. S. Mazzeo ◽  
G. A. Brooks ◽  
D. A. Schoeller ◽  
T. F. Budinger
Keyword(s):  
Blood Lactate ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Curvilinear Relationship ◽  
O2 Consumption ◽  
Lactate Oxidation ◽  
Respiratory Parameters ◽  
Steady Rate ◽  
Lactate Levels

Lactate irreversible disposal (RiLa) and oxidation (RoxLa) rates were studied in six male subjects during rest (Re), easy exercise [EE, 140 min of cycling at 50% of maximum O2 consumption (VO2max)] and hard exercise (HE, 65 min at 75% VO2max). Twenty minutes into each condition, subjects received a Na+-L(+)-[1–13C]lactate intravenous bolus injection. Blood was sampled intermittently from the contralateral arm for metabolite levels, acid-base status, and enrichment of 13C in lactate. Expired air was monitored continuously for determination of respiratory parameters, and aliquots were collected for determination of 13C enrichment in CO2. Steady-rate values for O2 consumption (VO2) were 0.33 +/- 0.01, 2.11 +/- 0.03, and 3.10 +/- 0.03 l/min for Re, EE, and HE, respectively. Corresponding values of blood lactate levels were 0.84 +/- 0.01, 1.33 +/- 0.05, and 4.75 +/- 0.28 mM in the three conditions. Blood lactate disposal rates were significantly correlated to VO2 (r = 0.78), averaging 123.4 +/- 20.7, 245.5 +/- 40.3, and 316.2 +/- 53.7 mg X kg-1 X h-1 during Re, EE, and HE, respectively. Lactate oxidation rate was also linearly related to VO2 (r = 0.81), and the percentage of RiLa oxidized increased from 49.3% at rest to 87.0% during exercise. A curvilinear relationship was found between RiLa and blood lactate concentration. It was concluded that, in humans, 1) lactate disposal (turnover) rate is directly related to the metabolic rate, 2) oxidation is the major fate of lactate removal during exercise, and 3) blood lactate concentration is not an accurate indicator of lactate disposal and oxidation.

scholarly journals Developmental changes in oxygen consumption regulation in larvae of the South African clawed frog Xenopus laevis

1995 ◽  
Vol 198 (12) ◽  
pp. 2465-2475 ◽  
Author(s):  
D Hastings ◽  
W Burggren
Keyword(s):  
Oxygen Consumption ◽  
Lactic Acid ◽  
Xenopus Laevis ◽  
South African ◽  
Acute Hypoxia ◽  
Lactate Concentration ◽  
Aerobic Metabolism ◽  
Whole Body ◽  
Lactate Levels ◽  
Clawed Frog

Well-developed larval Xenopus laevis (NF stages 58­66) are oxygen regulators, at least during mild hypoxia. When and how they change from oxygen conformers (the presumed condition of the fertilized egg) to oxygen regulators is unknown. Also unknown is how anaerobic metabolic capabilities change during development, especially in response to acute hypoxia, and to what extent, if any, anaerobiosis is used to supplement aerobic metabolism. Consequently, we have investigated resting rates of oxygen consumption (M.O2) and concentrations of whole-body lactate (lactic acid) during development in normoxia and in response to acute hypoxia in Xenopus laevis. M.O2 increased in an episodic, non-linear fashion during development. Resting, normoxic M.O2 increased about tenfold (to approximately 0.20 µmol g-1 h-1) between NF stages 1­39 and 40­44, and then another tenfold between NF stages 45­48 and 49­51 (to approximately 2.0 µmol g-1 h-1), remaining at about 2 µmol g-1 h-1 for the remainder of larval development. M.O2 reached its highest level in newly metamorphosed frogs (nearly 4 µmol g-1 h-1), before decreasing to about 1.0 µmol g-1 h-1 in large adults. X. laevis embryos and larvae up to NF stage 54­57 were oxygen conformers when exposed to variable levels of acute hypoxia. The only exception was NF stage 45­48 (external gills present yet body mass still very small), which showed some capability of oxygen regulation. All larvae older than stage 54­57 and adults were oxygen regulators and had the lowest values of Pcrit (the oxygen partial pressure at which M.O2 begins to decline). Whole-body lactate concentration in normoxia was about 1 µmol g-1 for all larval groups, rising to about 12 µmol g-1 in adults. Concentrations of lactic acid in NF stages 1­51 were unaffected by even severe ambient hypoxia. However, whole-body lactate levels in NF stages 52­66 increased in response to severe hypoxia, indicating that some anaerobic metabolism was being used to supplement diminishing aerobic metabolism. The largest increases in concentration of lactate occurred in late larvae and adults.

An Analysis of Acid-Base Disturbances in the Haemolymph Following Strenuous Activity in the Dungeness Crab, Cancer Magister

1979 ◽  
Vol 79 (1) ◽  
pp. 47-58
Author(s):  
D. G. McDONALD ◽  
B. R. McMAHON ◽  
C. M. WOOD
Keyword(s):  
Lactate Concentration ◽  
Dungeness Crab ◽  
Acid Base ◽  
Cancer Magister ◽  
Rapid Release ◽  
Strenuous Activity ◽  
Lactate Levels ◽  
Acid Base Disturbance ◽  
Base Disturbance

Enforced activity causes a marked depression of haemofymph pH in Cancer magister. Both lactate concentration and PCOCO2 of the haemolymph are elevated immediately following exercise but resting PCOCO2 is restored within 30 min whereas resting lactate levels are not restored for at least 8 h. The haemolymph acid-base disturbance is caused largely by elevated haemolymph lactate levels but a Davenport analysis based on measurements of pH and total CO2 reveals a marked discrepancy between the amount of metabolic acid buffered by the haemolymph and the lactate anion concentration. This appears due to a more rapid release of lactate from the tissues than H+ ions produced with lactate.

Effects of Combined Resistance Plus Aerobic Training on Body Composition, Muscle Strength, Aerobic Capacity, and Renal Function in Kidney Transplantation Subjects

2019 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Paulo S. Lima ◽  
Alexandre S. de Campos ◽  
Omar de Faria Neto ◽  
Teresa C.A. Ferreira ◽  
Carlos E.N. Amorim ◽  
...  
Keyword(s):  
Body Composition ◽  
Renal Function ◽  
Kidney Transplantation ◽  
Muscle Strength ◽  
Aerobic Capacity ◽  
Aerobic Training
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