Avenues for the Primary Prevention of Breast Cancer in the Second Millennium

Breast cancer (BC) has recently surpassed lung canceras the most frequently diagnosed cancer worldwide,with an estimated 19.3 million new cases and almost 10 1 million deaths occurring in 2020. A steady ascension in BC incidence has been a remarkable feature in cancer epidemiology for almost a century, and has been reported in richer as well as poorer communities all over the world. This trend is no doubt associated with the ageing of the global population: “Each one-year increase of population ageing (is) associated with a nearly ½ year increase of age at BC diagnosis.