MARKERS OF OXIDATIVE STRESS, INFLAMMATION, AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE WITH CONCOMITANT DYSLIPIDEMIA

На сегодняшний день одним из значимых факторов риска развития ИБС является дислипидемия. На основании имеющихся исследований можно сделать вывод, что среди пациентов с корорнарным атеросклерозом во всех возрастных группах большинство случаев развития ИБС обусловлено именно дислипидемией. Целью исследования стало изучение изменения маркеров окислительного стресса, воспаления и эндотелиальной дисфункции у больных коронарной болезнью сердца в зависимости от наличия дислипидемии. Материалы и методы: мы обследовали 336 пациентов с диагнозом коронарная болезнь сердца, верифицированной стандартизированными валидизированными критериями и клинико-функциональными методами, в возрасте от 47 до 75 лет. Наличие коронарного атеросклероза подтверждали проведением коронароангиографии с последующим расчетом индекса Gensini. По наличию дислипидемии пациенты были разделены на 2 группы: 1 группа - имевшие дислипидемию - 168 человек, 2 группа - не имевшие дислипидемию - 168 человек. Статистическая обработка результатов исследования проводилась с помощью пакетов программ SPSS Statistics 20. Результаты: В исследовании показаны особенности выраженности коронарного атеросклероза, рассчитанного по индексу Gensini, в зависимости от дислипидемии. Выявлены достоверные различия по показателям окислительной модификации белков, супероксиддисмутазы, С-реактивного белка и гомоцистеина. Кроме того, установлены взаимосвязи между наличием дислипидемии и изучаемыми биомаркерами, а также клинико-антропометрическими показателями. Установлена взаимосвязь между дислипидемией, выраженностью коронарного атеросклероза и изучаемыми факторами риска. Таким образом, коррекция факторов риска КБС остается на субоптимальном уровне, и значительная часть пациентов не привержена к их коррекции. Отмечена низкая приверженность к гиполипидемической терапии у пациентов с признаками коронарного атеросклероза. В связи с этим сохраняется необходимость поиска маркеров остаточного риска, принимая во внимание значимость факторов риска To date, one of the most significant risk factors for the development of CHD is dyslipidemia. Based on the available studies, it can be concluded that among patients with coronary atherosclerosis in all age groups, the majority of cases of CHD development are caused by dyslipidemia. The aim of the study was to study the changes in markers of oxidative stress, inflammation and endothelial dysfunction in patients with coronary heart disease, depending on the presence of dyslipidemia. Materials and methods: we examined 336 patients with a diagnosis of coronary heart disease, verified by standardized validated criteria and clinical and functional methods, aged 47 to 75 years. The presence of coronary atherosclerosis was confirmed by coronary angiography with subsequent calculation of the Gensini index. According to the presence of dyslipidemia, the patients were divided into 2 groups: group 1 - those who had dyslipidemia - 168 people, group 2 - those who did not have dyslipidemia - 168 people. Statistical processing of the study results was carried out using the SPSS Statistics 20 software packages. Results: The study shows the features of the severity of coronary atherosclerosis, calculated by the Gensini index, depending on dyslipidemia. Significant differences in the parameters of oxidative modification of proteins, superoxide dismutase, C-reactive protein, and homocysteine were revealed. In addition, the relationships between the presence of dyslipidemia and the studied biomarkers, as well as clinical and anthropometric indicators, were established. The relationship between dyslipidemia, the severity of coronary atherosclerosis and the studied risk factors was established. Thus, the correction of CBS risk factors remains at a suboptimal level, and a significant proportion of patients are not committed to their correction. Low adherence to lipid-lowering therapy was noted in patients with signs of coronary atherosclerosis. In this regard, it remains necessary to search for markers of residual risk, taking into account the significance of risk factors

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Changes in Indicators of Oxidative Stress, Inflammation and Endothelial Dysfunction in Patients with Coronary Heart Disease during Lipid-Lowering Therapy

International Journal of Biomedicine ◽

10.21103/article9(3)_oa2 ◽

2019 ◽

Vol 9 (3) ◽

pp. 202-204

Author(s):

Julia Kotova ◽

Anna Zuikova ◽

Aleksander Pashkov

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Endothelial Dysfunction ◽

Lipid Lowering ◽

Lipid Lowering Therapy ◽

Lowering Therapy

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Increased Plasma Markers of Oxidative Stress Are Associated with Coronary Heart Disease in Males with Diabetes Mellitus and with 10-Year Risk in a Prospective Sample of Males

Clinical Chemistry ◽

10.1373/clinchem.2005.060194 ◽

2006 ◽

Vol 52 (3) ◽

pp. 446-452 ◽

Cited By ~ 61

Author(s):

Jeffrey W Stephens ◽

David R Gable ◽

Steven J Hurel ◽

George J Miller ◽

Jackie A Cooper ◽

...

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Coronary Heart Disease ◽

Heart Disease ◽

Oxidized Ldl ◽

Total Antioxidant Status ◽

Cross Sectional ◽

Chd Risk ◽

Markers Of Oxidative Stress ◽

Plasma Markers

Abstract Background: Increased oxidative stress is associated with coronary heart disease (CHD). We examined the association between plasma markers of oxidative stress and CHD in a cross-sectional sample of patients with diabetes and prospective CHD risk in a sample of men predominantly without diabetes. Methods: Plasma total antioxidant status (TAOS) and the ratio of oxidized LDL (Ox-LDL) to LDL-cholesterol (LDL-C) were determined in a cross-section of 761 Caucasian individuals with diabetes (UDACS study). Plasma TAOS was also determined in 310 baseline samples from a 10-year prospective cohort of 3012 healthy males (NPHSII). Results: Within UDACS, males with CHD had lower mean (SD) plasma TAOS [no CHD, 43.4 (13.2)%; CHD, 40.3 (13.8)%; P = 0.04]. The prevalence of CHD was higher in the lowest compared with the upper quartiles (32.7% vs 19.7%; P = 0.004). We observed a significant association between plasma Ox-LDL:LDL-C and CHD status [no CHD vs CHD, 16.9 (3.1) vs 19.3 (5.0) units/mmol; P = 0.04], with the prevalence of CHD being higher among men in the upper compared with lower quartiles (18.4% vs 35.1%; P = 0.003). No association was observed in females. In NPHSII, TAOS was lower in those who developed CHD [35.1 (8.0)% vs 37.1 (7.9)%; P = 0.04]. The odds ratio for CHD in the lowest compared with the upper quartile was 1.91 (95% confidence interval, 0.99–3.70; P = 0.04). This remained unchanged after adjustment for classic risk factors. Conclusions: A cross-sectional and prospective association exists between baseline plasma measures of oxidative stress and CHD risk. The association with prospective CHD risk remained after adjustment for “traditional” risk factors, implying an independent role for oxidative stress in CHD risk.

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Coronary heart disease: issues of pathogenesis, diagnosis, treatment and medical and labor expertise

Medicina i vysokie tehnologii ◽

10.34219/2306-3645-2021-11-3-41-48 ◽

2021 ◽

Vol 3 ◽

Author(s):

D.Yu. Gamayunov ◽

◽

V.A. Khaptanova ◽

N.M. Balabina ◽

A.N. Kalyagin ◽

...

Keyword(s):

Risk Factors ◽

Coronary Heart Disease ◽

Heart Disease ◽

Angina Pectoris ◽

Stable Angina ◽

Lifestyle Modification ◽

Diagnostic Methods ◽

Lipid Lowering ◽

Lipid Lowering Therapy ◽

Stable Angina Pectoris

This article provides a review of the literature on coronary heart disease, namely stable angina pectoris – one of the forms of chronic coronary heart disease. The role of CHD in mortality and disability of the population is considered. The literature review describes the etiology, risk factors, classification, pathogenetic nature of the disease, diagnostic methods, and also addresses issues of treatment and medical and labor expertise that are relevant today. The importance of subjective and objective methods of examination along with highly informative laboratory and instrumental methods currently being introduced is noted. A fundamental step towards eliminating risk factors is lifestyle modification. Of particular relevance is the issue of drug treatment of stable angina pectoris, the main purpose of which is to reduce the symptoms of angina pectoris and prevent cardiovascular complications. The article presents data from clinical studies examining the effectiveness of modern antianginal, antithrombotic, lipid-lowering therapy. The data on the possibility of using the valsartan and sacubitril complex in order to reduce the risk of hospitalization and death in the presence of symptomatic CHF (LVEF ≤ 35%) are presented.

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GENDER FEATURES OF MARKERS OF ENDOTHELIAL DAMAGE, OXIDATIVE AND CELLULAR STRESS IN COMORBID CHD PATIENTS

"Medical & pharmaceutical journal "Pulse" ◽

10.26787/nydha-2686-6838-2021-23-2-36-41 ◽

2021 ◽

pp. 36-41

Author(s):

Kotova Yu.A. ◽

Zuikova A.A.

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Atherosclerosis ◽

Cellular Stress ◽

Endothelial Damage ◽

Stable Coronary Heart Disease ◽

Markers Of Oxidative Stress ◽

Gender Characteristics ◽

Shock Proteins

The main morbidity and mortality in the world is caused by cardiovascular diseases. In the structure of CVD, the largest percentage is coronary heart disease. The main cause of CHD is atherosclerosis. To date, it is believed that the prognosis of patients with stable coronary heart disease is primarily due to the severity of coronary atherosclerosis. But do not forget about the presence of comorbid pathology in patients, which is becoming increasingly relevant and has an impact on the quality of life of such patients. In addition, it is necessary to keep in mind the gender characteristics of the development of CHD and the adherence of patients with CHD to the treatment and diagnosis of their disease, depending on gender. The aim of the study was to study the gender characteristics of coronary atherosclerosis, changes in markers of endothelial damage, oxidative and cellular stress in comorbid CHD patients. The material for the study was a survey of 336 patients diagnosed with coronary heart disease, verified by standardized validated criteria and clinical and functional methods. The presence of coronary atherosclerosis in patients was confirmed by coronary angiography using the Judkins method. The severity of coronary atherosclerosis was determined based on the Gensini index. Gender differences in indicators of oxidative stress, cellular stress, inflammation and endothelial dysfunction were revealed. Analysis of the relationship between sex and the studied indicators revealed significant positive associations with the Gensini index and male sex, as well as with markers of oxidative stress; and significant negative associations with superoxide dismutase activity, as well as heat shock proteins 70.

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