scholarly journals The Role of Pharmacological Therapy and Psychotherapy in Post Stroke Depression

2021 ◽  
Vol 3 (1) ◽  
pp. 143-148
Author(s):  
Nurlia Puspita Ratnasari
Keyword(s):  
Health Services ◽  
Antidepressant Medication ◽  
Pharmacological Therapy ◽  
Post Stroke ◽  
Self Blame ◽  
Comprehensive Management ◽  
Emotional Illness ◽  
Comprehensive Health ◽  
Post Stroke Depression

The most prevalent emotional illness following a stroke is post-stroke depression. Some of the symptoms of post-stroke depression include loss of interest, decreased energy, decreased appetite, problems sleeping, self-blame, and even suicide thoughts. To overcome the symptoms of post-stroke depression requires comprehensive management. In the PSD population, antidepressant medication has demonstrated to be effective. In order to obtain comprehensive health services, rehabilitation activities are also required as one of the therapies in the psychological sector of patients with post-stroke depression.

scholarly journals Role of functional pharmacological therapy in post-stroke depression: a narrative review

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052095055
Author(s):  
Francesco Corallo ◽  
Chiara Scarfì ◽  
Francesca Antonia Arcadi ◽  
Caterina Formica ◽  
Marcella Di Cara ◽  
...  
Keyword(s):  
Selective Serotonin Reuptake Inhibitors ◽  
Cerebrovascular Diseases ◽  
Pharmacological Therapy ◽  
Narrative Review ◽  
Antidepressant Therapy ◽  
Exclusion Criteria ◽  
Post Stroke ◽  
Antidepressant Effects ◽  
Post Stroke Depression

Objective We conducted a narrative review to investigate whether antidepressant therapy, including the use of selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) or the use of supportive drugs (i.e., citicoline or choline alfoscerate) as a substitute for antidepressant therapy, reduces depression in patients with cerebrovascular diseases. Methods A systematic search of the PubMed and Web of Science databases was performed, including review articles and other studies to identify additional citations. Only 4 of 1566 publications met the inclusion/exclusion criteria and were selected. Results Studies showed that post-stroke depression (PSD) could be treated with antidepressant therapy, as well as supportive drugs such as citicoline or choline alfoscerate, which may have antidepressant effects. Conclusions The findings support the efficacy of citicoline as a treatment for depression. Studies aimed to discover the characteristics of these psychostimulants in relation to PSD treatment should be performed.

Oxidative Stress and Post-Stroke Depression: Possible Therapeutic Role of Polyphenols?

2014 ◽  
Vol 22 (3) ◽  
pp. 343-351 ◽  
Author(s):  
Seyed Nabavi ◽  
Olivia Dean ◽  
Alyna Turner ◽  
Antoni Sureda ◽  
Maria Daglia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Therapeutic Role ◽  
Post Stroke ◽  
Post Stroke Depression

Role of hypothalamic cannabinoid receptors in post-stroke depression in rats

2016 ◽  
Vol 121 ◽  
pp. 91-97 ◽  
Author(s):  
Shanshan Wang ◽  
Hong Sun ◽  
Sainan Liu ◽  
Ting Wang ◽  
Jinqun Guan ◽  
...  
Keyword(s):  
Cannabinoid Receptors ◽  
Post Stroke ◽  
Post Stroke Depression

Role of Medicinal Plants for Liver-Qi Regulation Adjuvant Therapy in Post-stroke Depression: A Systematic Review of Literature

2016 ◽  
Vol 31 (1) ◽  
pp. 40-52 ◽  
Author(s):  
Ling-Feng Zeng ◽  
Ye Cao ◽  
Lu Wang ◽  
Yun-Kai Dai ◽  
Ling Hu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Medicinal Plants ◽  
Adjuvant Therapy ◽  
Review Of Literature ◽  
Post Stroke ◽  
Post Stroke Depression

The role of inflammation in the development of post-stroke depression in elderly patients

2022 ◽  
pp. 841-847
Author(s):  
О.А. Осипова ◽  
Н.И. Клюшников ◽  
Е.В. Гостева ◽  
О.Н. Белоусова ◽  
Н.И. Жернакова ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Elderly Patients ◽  
Middle Age ◽  
The Elderly ◽  
Middle Aged ◽  
Post Stroke ◽  
Aged People ◽  
Tnf Α ◽  
Post Stroke Depression

Цель исследования - изучение роли цитокинов, соотношения нейтрофилов и лимфоцитов в развитии постинсультной депрессии (ПД) у больных пожилого возраста. В исследование были включены 110 больных с острым ишемическим инсультом, из них 60 человек среднего возраста (52±5 лет) и 50 - пожилого возраста (66±4 года). Контрольную группу составили 20 человек среднего возраста без инсульта в анамнезе. Через 3 мес наблюдения ПД в пожилом возрасте развилась у 28 (56 %) больных, в среднем возрасте - у 26 (43,3 %). Больные пожилого возраста с ишемическим инсультом, у которых развилась ПД, были достоверно старше (7,9 %, р<0,05), чаще имели артериальную гипертензию (12,4 %, р<0,05), уровень гликемии выше на 16,1 % (р<0,05), триглицеридов - на 14 % (р<0,05), ЛПНП - на 12,8 % (р<0,05). Больные среднего возраста с ПД имели ИМТ выше на 8,1 % (р<0,05), уровень гликемии - на 9,6 % (р<0,05), триглицеридов - на 10,9 % (р<0,05), ЛПНП - на 9,7 % (р<0,05), чем больные без депрессии. Пожилые больные с ишемическим инсультом и ПД имели более высокий уровень цитокинов - IL-1β был выше на 35,4 % (р<0,01), TNF-α - на 27 % (р<0,01), INF-γ - на 18 % (р<0,01), чем у больных без ПД. У больных пожилого возраста с ПД соотношение нейтрофилов и лимфоцитов (Н/Л) было на 46 % (p<0,001) выше, чем у больных без ПД. В группе больных пожилого возраста при наличии ПД соотношение Н/Л было на 50 % (p<0,001) выше, чем в аналогичной группе среднего возраста. Таким образом, у пожилых больных с ишемическим инсультом уровень маркеров воспаления может иметь прогностическое значение в развитии постинсультной депрессии. The aim of the study was to study the role of cytokines, the ratio of neutrophils and lymphocytes in the development of post-stroke depression in elderly patients. The study included 110 patients with acute ischemic stroke, including 60 middle-aged people (52±5 years) and 50 elderly people (66±4 years). The control group consisted of 20 middle-aged people without a history of stroke. After 3 months of follow-up, post-stroke depression (PSD) developed in the elderly in 28 patients (56 %), in the middle age in 26 patients (43,3 %). Patients with ischemic stroke in the elderly who developed PSD were significantly older (7,9 %, p<0,05), more often had arterial hypertension (12,4 %, p<0,05), the level of glucose was 16,1 % higher (p<0,05), triglycerides by 14 % (p<0,05), LDL-C by 12,8 % (p<0,05). In middle age, patients with post-stroke depression had a body mass index higher by 8,1 % (p<0,05), a glucose level by 9,6 % (p<0,05), triglycerides by 10,9 % (p<0,05), LDL-C by 9,7 % (p<0,05) than patients without PSD. Elderly patients with ischemic stroke and PSD had higher levels of cytokines - IL-1β was 35,4 % higher (p<0,01), TNF-α by 27 % (p<0,01), INF-γ by 18 % (p<0,01) than in patients without PSD. In elderly patients with PSD, the ratio of neutrophils and lymphocytes (N/L) is 46 % (p<0,001) higher than in patients without PSD. In the elderly, in the presence of PSD, the N/L ratio was 50 % (p<0,001) higher than in the same middle-aged group. Thus, in elderly patients with ischemic stroke, the level of inflammatory markers may have a prognostic value in the development of post-stroke depression.

Pharmacological therapy of post-stroke depression

Psihiatru ro ◽  
2019 ◽  
Vol 2 (57) ◽  
pp. 18
Author(s):  
Octavian Vasiliu ◽  
Ileana Marinescu ◽  
Daniel Vasile
Keyword(s):  
Pharmacological Therapy ◽  
Post Stroke ◽  
Post Stroke Depression

scholarly journals Role of mHealth in overcoming the occurrence of post-stroke depression

2017 ◽  
Vol 137 (1) ◽  
pp. 12-19 ◽  
Author(s):  
J. J. Miranda ◽  
M. G. Moscoso ◽  
M. Toyama ◽  
V. Cavero ◽  
F. Diez-Canseco ◽  
...  
Keyword(s):  
Post Stroke ◽  
Post Stroke Depression

scholarly journals Fluoxetine-induced recovery of serotonin and norepinephrine projections in a mouse model of post-stroke depression

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Amin Zahrai ◽  
Faranak Vahid-Ansari ◽  
Mireille Daigle ◽  
Paul R. Albert
Keyword(s):  
Nucleus Accumbens ◽  
Basolateral Amygdala ◽  
Chronic Treatment ◽  
Memory Deficits ◽  
Cingulate Gyrus ◽  
Axonal Plasticity ◽  
Post Stroke ◽  
Antidepressant Effects ◽  
Post Stroke Depression

Abstract Chronic treatment with fluoxetine (FLX) is required for its antidepressant effects, but the role of serotonin (5-HT) axonal plasticity in FLX action is unknown. To address this, we examined mice with a stroke in the left medial prefrontal cortex (mPFC) resulting in persistent anxiety-like and depression-like behaviors and memory deficits as a model of post-stroke depression. Chronic treatment with FLX (but not exercise) completely reversed the behavioral phenotype and partially reversed changes in FosB-labeled cells in the mPFC, nucleus accumbens, septum, hippocampus, basolateral amygdala (BLA), and dorsal raphe. In these regions, 5-HT or norepinephrine (NE) innervation was quantified by staining for 5-HT or NE transporters, respectively. 5-HT synapses and synaptic triads were identified as synaptophysin-stained sites on 5-HT axons located proximal to gephyrin-stained or PSD95-stained spines. A week after stroke, 5-HT innervation was greatly reduced at the stroke site (left cingulate gyrus (CG) of the mPFC) and the left BLA. Chronically, 5-HT and NE innervation was reduced at the left CG, nucleus accumbens, and BLA, with no changes in other regions. In these areas, pre-synaptic and post-synaptic 5-HT synapses and triads to inhibitory (gephyrin+) sites were reduced, while 5-HT contacts at excitatory (PSD95+) sites were reduced in the CG and prelimbic mPFC. Chronic FLX, but not exercise, reversed these reductions in 5-HT innervation but incompletely restored NE projections. Changes in 5-HT innervation were verified using YFP staining in mice expressing YFP-tagged channelrhodopsin in 5-HT neurons. Thus, FLX-induced 5-HT axonal neuroplasticity of forebrain projections may help mediate recovery from brain injury.

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