scholarly journals FEATURES OF EXPRESSION OF OCT4, NANOG AND ENDOGLIN IN RENAL CELL CARCINOMAS

2021 ◽  
Vol 10 (3) ◽  
pp. 31-38
Author(s):  
Y. I. Osmanov ◽  
E. A. Kogan ◽  
G. A. Demyashkin ◽  
A. S. Talanov ◽  
V. I. Shchekin
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Positive Response ◽  
Prognostic Significance ◽  
Comparative Assessment ◽  
Nanog Expression ◽  
Histological Variants ◽  
Histological Variant ◽  
Single Tumor

Possibilities of the potential stem markers as cancer stem cells in renal cell carcnomas (RCC) and their prognostic significance are currently being studied. In this regard, the study of the expression pattern of transcription factors – NANOG and OCT4, as well as endoglin in the RCC is of great interest. The aim of the study was to conduct a comparative assessment of the expression of stem markers NANOG, OCT4, and CD105 in histological variants of renal cell carcinoma and determine their prognostic significance. Material and methods. The study was performed on surgical material from 225 patients with renal cell carcinoma. Antibodies used: NANOG, OCT4 and CD105. The nonparametric Pearson agreement test (χ2) was used to identify the differences between the compared groups. Results. NANOG expression was detected in 150 (66.7%) cases. Nuclear expression of OCT4 was detected in 72 (32%) samples in only single tumor cells. A positive response to CD105 was determined in 60 cases (26.7%). Conclusion. Reliable associations between the expression of CD105 and clinical parameters were revealed depending on the histological variant of renal cell carcinoma.

919 High nuclear grade has strong prognostic significance in patients with pathologic T1a renal cell carcinoma

2012 ◽  
Vol 11 (1) ◽  
pp. e919-e919a
Author(s):  
K. Suzuki ◽  
R. Mizuno ◽  
S. Mikami ◽  
N. Tanaka ◽  
K. Kanao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Significance ◽  
Nuclear Grade ◽  
High Nuclear Grade

Prognostic Significance of Increases in Hemoglobin in Renal Cell Carcinoma Patients During Treatment With VEGF-directed Therapy

2017 ◽  
Vol 15 (3) ◽  
pp. 396-402 ◽  
Author(s):  
Abhishek Tripathi ◽  
Susanna Jacobus ◽  
Hope Feldman ◽  
Toni K. Choueiri ◽  
Lauren C. Harshman
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Significance

Evaluation of Tumor Pseudocapsule Status and its Prognostic Significance in Renal Cell Carcinoma

2018 ◽  
Vol 199 (4) ◽  
pp. 915-920 ◽  
Author(s):  
Wei Xi ◽  
Jiajun Wang ◽  
Li Liu ◽  
Ying Xiong ◽  
Yang Qu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Significance

scholarly journals A Mitochondrial Dysfunction and Oxidative Stress Pathway-Based Prognostic Signature for Clear Cell Renal Cell Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-32
Author(s):  
Yue Wu ◽  
Xi Zhang ◽  
Xian Wei ◽  
Huan Feng ◽  
Bintao Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Risk Group ◽  
Prognostic Significance ◽  
Individual Risk ◽  
Cell Renal Cell Carcinoma

Mitochondria not only are the main source of ATP synthesis but also regulate cellular redox balance and calcium homeostasis. Its dysfunction can lead to a variety of diseases and promote cancer and metastasis. In this study, we aimed to explore the molecular characteristics and prognostic significance of mitochondrial genes (MTGs) related to oxidative stress in clear cell renal cell carcinoma (ccRCC). A total of 75 differentially expressed MTGs were analyzed from The Cancer Genome Atlas (TCGA) database, including 46 upregulated and 29 downregulated MTGs. Further analysis screened 6 prognostic-related MTGs (ACAD11, ACADSB, BID, PYCR1, SLC25A27, and STAR) and was used to develop a signature. Kaplan-Meier survival and receiver operating characteristic (ROC) curve analyses showed that the signature could accurately distinguish patients with poor prognosis and had good individual risk stratification and prognostic potential. Stratified analysis based on different clinical variables indicated that the signature could be used to evaluate tumor progression in ccRCC. Moreover, we found that there were significant differences in immune cell infiltration between the low- and high-risk groups based on the signature and that ccRCC patients in the low-risk group responded better to immunotherapy than those in the high-risk group (46.59% vs 35.34%, P = 0.008 ). We also found that the expression levels of these prognostic MTGs were significantly associated with drug sensitivity in multiple ccRCC cell lines. Our study for the first time elucidates the biological function and prognostic significance of mitochondrial molecules associated with oxidative stress and provides a new protocol for evaluating treatment strategies targeting mitochondria in ccRCC patients.

Interleukin-4 Promoter Polymorphisms: A Genetic Prognostic Factor for Survival in Metastatic Renal Cell Carcinoma

2007 ◽  
Vol 25 (7) ◽  
pp. 845-851 ◽  
Author(s):  
Thomas Kleinrath ◽  
Christoph Gassner ◽  
Peter Lackner ◽  
Martin Thurnher ◽  
Reinhold Ramoner
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cox Regression ◽  
Clinical Course ◽  
Prognostic Significance ◽  
Interleukin 4 ◽  
Promoter Polymorphisms ◽  
Cox Regression Analysis ◽  
Metastatic Rcc

Purpose Renal cell carcinoma (RCC) is considered a cytokine-responsive tumor. The clinical course of a patient may thus be influenced by the patient's capacity to produce distinct cytokines. Therefore, cytokine gene polymorphisms in RCC patients were analyzed to determine haplotype combinations with prognostic significance. Patients and Methods A selection of 21 single nucleotide polymorphisms within the promoter regions of 13 cytokine genes were analyzed in a cross-sectional single-center study of 80 metastatic RCC patients. Univariate and multivariate analyses and the Cox forward-stepwise regression model were chosen to assess genetic risk factors. Results Multivariate Cox regression analysis confirmed by a bootstrap technique identified the heterozygous IL4 genotype −589T−33T/−589C−33C as an independent prognostic risk factor (risk ratio, 3.1; P < .01; 95% CI, 1.4 to 6.9; adjusted for age, sex, and nuclear grading) in metastatic RCC patients. IL4 haplotype −589T−33T and −589C−33C were found with a frequency of 0.069 and 0.925, respectively, which represents a two-fold decrease of IL4 haplotype −589T−33T (P < .01) and an increase of IL4 haplotype −589C−33C frequency (P < .05) in metastatic RCC compared with other white reference study populations. The median overall survival was decreased 3.5-fold (P < .05) in heterozygote patients carrying IL4 haplotype −589T−33T and −589C−33C (3.78 months) compared with patients homozygote for IL4 haplotype −589C−33C (13.44 months). In addition, a linkage disequilibrium between the IL4 gene and the KIF3A gene was detected. Conclusion Our findings indicate that IL4 promoter variants influence prognosis in patients with metastatic RCC and suggest that genetically determined interleukin-4 (IL-4) production affects the clinical course of the disease possibly through regulation of immune surveillance.

Management and prognostic significance hypercalcemia in renal cell carcinoma

Urology ◽  
1989 ◽  
Vol 33 (3) ◽  
pp. 167-170 ◽  
Author(s):  
Stuart A. Chasan ◽  
L.Ralph Pothel ◽  
Robert E. Huben
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Significance
Sign in / Sign up

Export Citation Format

Share Document