Methylene Blue Staining Test in Assessing Disease Free Marginsin Head and Neck Cancers

Despite remarkable advancements in medicine, cancers remain one of the most challenging pathologies for doctors. Head and neck neoplasms especially raise serious management problems due to the often advanced stage at the moment of diagnosis, associated with difficult curative interventions that impose significant changes in the quality of life of patients. Whenever possible, a complete removal of the tumor with disease free margins significantly increases the rate of survival. During surgery, assessing the limit of resection up to healthy tissue is crucial in order to attempt a curative intervention. The purpose of this paper is to evaluate the use of the methylene blue staining test in assessing the margins of resection during interventions for head and neck cancers.

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Methylene Blue Staining Test in Early Detection of Head and Neck Cancers

Revista de Chimie ◽

10.37358/rc.17.6.5645 ◽

2017 ◽

Vol 68 (6) ◽

pp. 1222-1224

Author(s):

Catalin Stefan ◽

Gabriel Lostun ◽

Alexandra Lostun

Keyword(s):

Methylene Blue ◽

Head And Neck ◽

Current Trend ◽

Head And Neck Cancers ◽

Blue Staining ◽

Important Health ◽

Poor Outcomes ◽

The Impact ◽

Lower Adherence

Head and neck cancers represent an important health problem in the present time. Due to the often late diagnosis and the significant changes that accompany the therapy associated with this disease, the impact on the quality of life of the patient is remarkable, causing a lower adherence to treatment, poor outcomes and an unfavorable prognosis. The current trend focuses on methods of investigation that allow an early diagnosis, which in turn translates into minimally invasive interventions with a favorable outcome. The purpose of this paper is to present the methylene blue staining method as an diagnosis tool, allowing the surgeon a better evaluation of the tumor and a more reliable limit of resection.

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Filipino head and neck cancer patients and their quality of life

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20200540 ◽

2020 ◽

Vol 6 (3) ◽

pp. 439

Author(s):

Frederic Ivan L. Ting ◽

Aylmer Rex B. Hernandez ◽

Reno Eufemon P. Cereno ◽

Irisyl B. Orolfo-Real ◽

Corazon A. Ngelangel

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

The Philippines ◽

Head And Neck Cancers ◽

The Social ◽

The University

Background: In the management of head and neck cancer (HNC), assessment of quality of life (QoL) is imperative because of the potentially debilitating effect of treatment toxicities. Currently, there are no published data assessing the QoL in Filipino HNC patients, thus this study.Methods: This cross-sectional study utilized the University of the Philippines - Department of Health Quality of Life scale. Patients with head and neck cancers at the University of the Philippines - Philippine General Hospital from February to September 2019 were invited to participate. Results: A total of 418 patients were included in the study with a mean age of 42 years old (range 18 to 73 years old). In general, Filipino head and neck cancer patients had moderate QoL (mean score of 4.59±0.79). All of the QoL domains (physical, emotional, cognitive, and related functions) had a score of 3-5 (moderate), except for the social status domain which had a mean score of 5.51±0.83 (high). Among socio-demographic factors, patients who are employed and with additional funding sources on top of their income have better global QoL (p<0.01). Clinically, patients with higher stages of disease, fungating tumors, post-laryngectomy, have a feeding tube, with a tracheostomy, and had chemotherapy have lower global QoL (p<0.01).Conclusions: Filipino patients with head and neck cancers have an overall moderate quality of life, with high scores in the social domain. Patients with higher tumor burdens and have been exposed to chemotherapy have lower QoL scores, while patients with financial stability and aid have better QoL scores.

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Analysis of dysphagia in advanced-stage head-and-neck cancer patients: impact on quality of life and development of a preventive swallowing treatment

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-018-5054-9 ◽

2018 ◽

Vol 275 (8) ◽

pp. 2159-2167 ◽

Cited By ~ 11

Author(s):

Ilaria Carmignani ◽

Luca Giovanni Locatello ◽

Isacco Desideri ◽

Pierluigi Bonomo ◽

Emanuela Olmetto ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Advanced Stage

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Radiotherapy-related quality of life in patients with head and neck cancers: a meta-analysis

Supportive Care in Cancer ◽

10.1007/s00520-019-05077-5 ◽

2019 ◽

Vol 28 (6) ◽

pp. 2701-2712 ◽

Cited By ~ 2

Author(s):

Xiuhong Ge ◽

Zhengluan Liao ◽

Jianhua Yuan ◽

Dewang Mao ◽

Yumei Li ◽

...

Keyword(s):

Quality Of Life ◽

Head And Neck ◽

Meta Analysis ◽

Head And Neck Cancers ◽

Related Quality

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Change in quality of life (QOL) and function within the first year in patients who received primary or post-operative radiotherapy for advanced stage head and neck cancer

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/s0360-3016(01)02576-7 ◽

2001 ◽

Vol 51 (3) ◽

pp. 408-409

Author(s):

C.K. Gwede ◽

D. Johnson ◽

B. Sauder ◽

H. Divan ◽

A. Trotti

Keyword(s):

Quality Of Life ◽

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

First Year ◽

Advanced Stage ◽

And Function

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Effect of oral pilocarpine on xerostomia and quality of life in patients receiving curative radiotherapy for head and neck cancers

Journal of Clinical Oncology ◽

10.1200/jco.2007.25.18_suppl.6088 ◽

2007 ◽

Vol 25 (18_suppl) ◽

pp. 6088-6088

Author(s):

S. Goyal ◽

D. N. Sharma ◽

P. K. Julka ◽

G. K. Rath

Keyword(s):

Quality Of Life ◽

Head And Neck ◽

Phase Ii ◽

Head And Neck Cancers ◽

Functional Scores ◽

Symptom Scores ◽

Oral Dryness ◽

Group A ◽

Group B

6088 Background: Xerostomia is the most debilitating condition following irradiation (RT) in patients with head and neck cancers. The present study intended to evaluate the effect of salivary stimulants such as pilocarpine given concurrent with RT on xerostomia and quality of life in these patients. Methods: In a prospective study conducted between July 2004 and May 2006, 60 patients receiving curative (radical or postoperative) RT for squamous cell head and neck carcinoma were randomized into two groups; group A (n=30) received concurrent pilocarpine 5 mg thrice daily for 12 weeks starting on day 1 of RT while group B (n=30) did not receive pilocarpine. Xerostomia was assessed using RTOG/EORTC criteria, and Quality of life (QOL) using EORTC QLQ-C30 version 3.0 and QLQ-H&N35 questionnaires in phases I-V: preradiation, week 4 of RT, and at 1, 3 and 6 months following completion of RT. Results: Oral dryness was the commonest toxicity, its incidence in phase II being 80% in group A and 89% in group B. By phase V, 13% patients in group A and none in group B had recovered to their pretreatment status. When compared with group B, group A had a significantly lower incidence of oral dryness in phases III (p=0.001), IV (p=0.014) and V (p=0.009) and lesser speech difficulty in phase V (p=0.021). QOL evaluation showed a decline in functional scores and rise in symptom scores during radiation with subsequent improvement to pretreatment levels in phase V. Group A had a significantly higher physical functioning score than group B in phases III (p=0.037) and IV (p=0.027), a better emotional functioning score in phases III (p=0.046) and IV (p=0.008), and a higher global health score, especially in phases II (p=0.012) and III (p=0.001). QLQ-C30 symptom scores were comparable between the 2 groups while H&N35 symptom scores were higher in group B with higher painkiller use in phase II (p=0.043) and IV (p=0.011), and higher dryness (p=0.025), sticky saliva (p=0.021) and constipation (p=0.011) in phase IV. Conclusions: Concurrent pilocarpine during head and neck RT helps maintain salivary function, reduces xerostomia and improves the quality of life in these patients, both during and after RT, especially in terms of parameters related directly to xerostomia. No significant financial relationships to disclose.

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Moving palliative care upstream for patients diagnosed with head and neck cancers.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.29_suppl.227 ◽

2020 ◽

Vol 38 (29_suppl) ◽

pp. 227-227

Author(s):

Tamara M Day

Keyword(s):

Quality Of Life ◽

Palliative Care ◽

Head And Neck ◽

Symptom Burden ◽

Psychosocial Distress ◽

Head And Neck Cancers ◽

Improve Quality ◽

Convenience Sample

227 Background: Adults with cancer face complex treatment choices and symptom burden that impact their quality of life. Goals of palliative care (PC) are to reduce symptom burden and improve quality of life. Strong evidence exists that PC helps reduce symptom burden, decreases hospital utilization, and improve quality of life. Yet, PC remains underutilized, especially in the context of cancer care. Methods: This descriptive longitudinal study evaluated whether use of a psychosocial distress screening tool would help identify patients eligible for PC. A convenience sample of adults with diagnosis of head and neck cancers presenting to an otolaryngology clinic, located in the cancer center of a Midwestern academic health system, were screened for eligibility for PC referral. If eligible, the provider was notified and introduced PC to the patient. Upon acceptance, a PC referral was ordered. The project consisted of baseline (n = 61) and follow-up chart reviews (n = 60) of patients seen in clinic during over a 3-month period. Results: We found an increase in PC referrals from 14.6% at baseline to 30.8% in follow-up, a 227% increase. Psychosocial distress screenings increased from 5% at baseline to 45% in follow-up, an increase of 200%. Of patients who received a PC referral, 85.6% accepted. There were statistically significant differences found between the pre- and post-intervention groups for marital status, χ2 (3) = 9.67, ( p = .02); and cancer stage χ2 (4) = 21.35, ( p = .00) with increased referrals for married patients at higher cancer stages in the prospective group. Conclusions: This study has shown physicians maybe more likely to offer PC referrals based on cancer stages, and not based on psychosocial distress symptoms. Potential barriers to early referral to PC were identified and could serve as useful information for future studies.

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Robotic surgery of head and neck cancers, a narrative review

European Journal of Translational Myology ◽

10.4081/ejtm.2020.8727 ◽

2020 ◽

Vol 30 (2) ◽

pp. 297-303

Author(s):

Farbood Kalantari ◽

Shahin Rajaeih ◽

Ali Daneshvar ◽

Zahra Karbasi ◽

Mohammad Mahdi Salem

Keyword(s):

Quality Of Life ◽

Robotic Surgery ◽

Head And Neck ◽

Neck Cancer ◽

Transoral Robotic Surgery ◽

The Body ◽

Head And Neck Cancers ◽

Organ Function ◽

Advantages And Disadvantages

Head and neck cancers are the most common cancers in the body. Treatments are determined on the basis of the location and stage of the primary tumor. The goal of treatment is to eliminate the tumor, prevent recurrence or metastasis, and maintain the quality of life. There are several treatments available for the management of head and neck cancers, including surgery, radiation therapy, chemotherapy, new molecular agents, and a combination of them. Transoral robotic technique is a short-time operation using a type of robotic machine in which the patient undergoes anesthesia for a shorter time and the side effects of this operation and the time of hospitalization are less than open surgery. Due to the importance of speed and accuracy in head and neck cancer surgery and the importance of application of robotics in surgery, the present study was designed and implemented to review the application of robotics in the management of head and neck cancers. In this review study, the keywords: application, robotic, surgical, head cancer, transoral robotic surgery (TORS), and neck cancer, were searched in ISI, PubMed, Scopus, Google scholar databases. Related articles written domestically or abroad that have covered areas such as the background of transoral robotic surgery, maintaining organ function and approaches, the advantages and disadvantages of TORS, the affordability of TORS, the combination of TORS with other therapeutic approaches published from 2003 to 2019 were reviewed. The use of robotic surgery for precise operations such as head and neck cancers seems to be essential. More advanced robotic devices are expected to expand the surgery treatment for head and neck cancers as well as the results of using TORS for oncologic optimization and acceptability of results while maintaining organ function and patient's quality of life.

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