Salivary a-amylase Activity-a Novel Non-Invasive Biomarker in Clinical Pathology

2018 ◽  
Vol 69 (3) ◽  
pp. 728-730
Author(s):  
Sebastian Cozma ◽  
Cristian Martu ◽  
Cristina Mihaela Ghiciuc ◽  
Francesca Romana Patacchioli ◽  
Lucia Corina Dima Cozma

Salivary biomarkers have developed into biological clinical research because they are accessible and easily obtained. Salivary a-amylase was proposed as an associat marker of salivary cortisol in assessing stress and at the same time as a possible non-invasive indicator of autonomic nervous system activation. Studies conducted so far have tested a-amylase activity in psychiatric disorders, diabetic neuropathy, lung disease, and autonomic nervous system activation in hypertension or heart failure.

CNS Spectrums ◽  
2007 ◽  
Vol 12 (8) ◽  
pp. 625-634 ◽  
Author(s):  
David S. Shannahoff-Khalsa

ABSTRACTResearch advances have led to three methods for selectively activating one half of the autonomic nervous system in humans.The first method is an ancient yogic technique called unilateral forced nostril breathing (UFNB) that employs forced breathing through only one nostril while closing off the other. The second method works by stimulation of an autonomic reflex point on the fifth intercostal space near the axilla. The most recent method employs unilateral vagus nerve stimulation (VNS) via the mid-inferior cervical branch and requires surgical implantation of a wire and pacemaker. UFNB is non-invasive and seems to selectively activate the ipsilateral branch of the sympathetic nervous system with a possible compensation effect leading to contralateral VNS. UFNB and VNS have been employed to treat psychiatric disorders. While UFNB has been studied for its potential effects on the endogenous ultradian rhythms of the autonomic and central nervous system, and their tightly coupled correlates, VNS has yet to be studied in this regard. This article reviews these three methods and discusses their similarities, putative mechanisms, their studied effects on the endogenous autonomic nervous system and central nervous system rhythms, and their implications for the treatment of psychiatric disorders.


2020 ◽  
Vol 17 (9) ◽  
pp. 4385-4393
Author(s):  
S. Chandana ◽  
B. R. Purnima ◽  
Prabhu Ravikala Vittal

Modern games consists of digital gaming consoles that involves interaction with a user and has an interface to generate visual feedback through 2D/3D monitor. These games have several psychological side effects like loss of spatial awareness, back pains, insomnia, addiction, aggression, stress, and hypertension. Virtual reality (VR) Gaming is one of the most emerging and novel technologies in the field of entertainment. Evaluation of this new technology has become important in order to analyze the effects of its predecessors (2D and 3D gaming). The main focus of this paper is on detection of stress levels in individuals due to VR gaming and classify them depending on their sympathetic and parasympathetic dominance. This is done through acquisition of electrocardiogram (ECG) and photo plethysmograph signals (PPG) signals and extracting their time domain and frequency domain features before, during and after gaming (Fatma Uysal and Mahmut Tokmakçi, 2018. Evaluation of stress parameters based on heart rate variability measurement. Department of Biomedical Engineering, Erciyes University, Kayseri, Turkey. [email protected], [email protected]., da Silva1, A.G.C.B., Arauj, D.N., et al, 2018. Increase in perceived stress is correlated to lower heart rate variability in healthy young subjects. Departamento de Fisioterapia, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. s/n., 81531–980, Curitiba, Parana, Brazil. E-mail: [email protected].). The physiological signal variation is analyzed by performing Heart Rate Variability (HRV) analysis over ECG signals which is one of the fast emerging methods in non-invasive research and clinical tools for assessing autonomic nervous system function (Juan Sztajzel, 2004. Heart rate variability: Aa non-invasive electrocardiographic method to measure the autonomic nervous system. Cardiology Center and Medical Policlinics, University Hospital, Geneva, Switzerland, SWISS MED WKLY 2004;134:514–522. www.smw.ch). Pulse-transmissiontime-variability (PTTV), which is extracted, has high coherence with heart rate variability and is also used as an objective measure of stress. In this paper we obtain the response of an individual during VR gaming and correlate them with the HRV/PTT parameters. The game chosen for the data acquisition was ‘VR city view rope crossing-360 android VR,’ during which data recording is done. It was found that there was a quantitative increase in physiological stress when individuals were exposed to virtual high heights in comparison with time relative to unaltered viewing. Mean Heart rate showed a significant increase during gaming for both boys and girls which indicates that the body is under the influence of a sympathetic activity like a physical exercise.


1995 ◽  
Vol 50 (3) ◽  
pp. 373-374
Author(s):  
Hiroshi Sato ◽  
Machiko Yamamoto ◽  
Shichiro Abe ◽  
Akihisa Yabe ◽  
Hiroyuki Iinuma ◽  
...  

2011 ◽  
Vol 148 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Linda M. Ueno ◽  
Luciano F. Drager ◽  
Ana C.T. Rodrigues ◽  
Maria U.P.B. Rondon ◽  
Wilson Mathias ◽  
...  

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