Choroidal Thickness Increase After Latanoprost Treatment

2001 ◽  
Vol 71 (3) ◽  
pp. 29-33
Author(s):  
Ileana Ramona Barac ◽  
Claudia Mehedintu ◽  
Andreea Diana Barac ◽  
George Balta ◽  
Lacramioara Brinduse ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Choroidal Thickness ◽  
Prostaglandin Analogue ◽  
Newly Diagnosed ◽  
Post Intervention ◽  
Thickness Increase ◽  
Subfoveal Choroidal Thickness ◽  
Before And After ◽  
Glaucoma Treatment

Latanoprost is the first prostaglandin analogue introduced for glaucoma treatment whose action is not fully understood until today. The purpose of this study is to evaluate the effect of latanorpost on choroidal thickness in a group of 16 eyes in patients newly diagnosed with glaucoma using last generation OCT (Optical Coherence Tomography). The IOP (intraocular pressure) and the subfoveal choroidal thickness were measured before and after one week, one month, 3 and 6 months of treatment with latanoprost. The subfoveal choroidal thickness was 219.2�63.8�m before treatment and 255.6�76.4�m after one week of treatment. Increased thickness of the choroid seven days post-intervention correlates with decreased intraocular pressure from 29.0�3.2mmHg pre-intervention to 17.6�3.1mmHg p[0.001 (p=0.018). The results of this study confirm the idea of latanoprost uveoscleral alternative drainage increase.

scholarly journals The effects of tolterodine on anterior segment and choroidal thickness in patients with overactive bladder syndrome

2017 ◽  
Vol 9 (5) ◽  
pp. 91-97 ◽  
Author(s):  
Hande Hüsniye Telek ◽  
Omer Gokhan Doluoglu ◽  
Ayse Burcu ◽  
Gulizar Demirok ◽  
Firdevs Ornek ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Choroidal Thickness ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Mean Value ◽  
Subfoveal Choroidal Thickness ◽  
Chamber Volume ◽  
Before And After ◽  
The Mean

Background: To evaluate the effects of tolterodine on anterior segment and choroidal thickness by using the Pentacam system and optical coherence tomography (OCT) (Pentacam). Methods: A total of 122 eyes of 61 patients (34 female; 27 male) were included in the study. All patients underwent a regular ocular examination and intraocular pressure measurements before and after 3 months of antimuscarinic drug tolterodine treatment, in addition, pupil diameter, anterior chamber depth, anterior chamber volume, anterior chamber angle, and lens thickness were measured through Pentacam (Oculus Inc., Wetzlar, Germany) system. Measurements of choroidal thickness were performed by OCT (Spectralis®, Heidelberg Engineering, Heidelberg, Germany). Results: The mean age was 58.4 ± 7.3 years and 56.5 ± 11.1 years for female and male patients. The mean intraocular pressure was 15.10 ± 2.75 mmHg before treatment and 15.18 ± 2.65 mmHg after treatment. Pupil diameters were 3.09 ± 0.48 mm before treatment and 3.12 ± 0.43 mm after treatment. Anterior chamber depth, before and after treatment were 2.68 ± 0.65 mm and 2.70 ± 0.61 mm. The mean value for subfoveal choroidal thickness was 267.92 ± 81.35 μm before the administration of tolterodine, whereas the mean choroidal thickness was 271.83 ± 75.42 μm after the administration of tolterodine. The alterations in the subfoveal choroidal thickness were not statistically significant ( p = 0.862). Conclusions: After 3 months of therapy with tolterodine, there were no significant changes in anterior segment parameters and choroidal thickness.

scholarly journals Automatic Segmentation of Choroid Layer Using Deep Learning on Spectral Domain Optical Coherence Tomography

2021 ◽  
Vol 11 (12) ◽  
pp. 5488
Author(s):  
Wei Ping Hsia ◽  
Siu Lun Tse ◽  
Chia Jen Chang ◽  
Yu Len Huang
Keyword(s):  
Optical Coherence Tomography ◽  
Deep Learning ◽  
Choroidal Thickness ◽  
Automatic Segmentation ◽  
Average Error ◽  
Good Prediction ◽  
Optical Coherence ◽  
Learning Method ◽  
Subfoveal Choroidal Thickness ◽  
Fully Connected

The purpose of this article is to evaluate the accuracy of the optical coherence tomography (OCT) measurement of choroidal thickness in healthy eyes using a deep-learning method with the Mask R-CNN model. Thirty EDI-OCT of thirty patients were enrolled. A mask region-based convolutional neural network (Mask R-CNN) model composed of deep residual network (ResNet) and feature pyramid networks (FPNs) with standard convolution and fully connected heads for mask and box prediction, respectively, was used to automatically depict the choroid layer. The average choroidal thickness and subfoveal choroidal thickness were measured. The results of this study showed that ResNet 50 layers deep (R50) model and ResNet 101 layers deep (R101). R101 U R50 (OR model) demonstrated the best accuracy with an average error of 4.85 pixels and 4.86 pixels, respectively. The R101 ∩ R50 (AND model) took the least time with an average execution time of 4.6 s. Mask-RCNN models showed a good prediction rate of choroidal layer with accuracy rates of 90% and 89.9% for average choroidal thickness and average subfoveal choroidal thickness, respectively. In conclusion, the deep-learning method using the Mask-RCNN model provides a faster and accurate measurement of choroidal thickness. Comparing with manual delineation, it provides better effectiveness, which is feasible for clinical application and larger scale of research on choroid.

scholarly journals Choroidal thickness in eyes with different degrees of myopia

2013 ◽  
Vol 6 (4) ◽  
pp. 34-38 ◽  
Author(s):  
Yuriy Sergeyevich Astakhov ◽  
Svetlana Georgiyevna Belekhova
Keyword(s):  
Optical Coherence Tomography ◽  
Negative Correlation ◽  
Choroidal Thickness ◽  
Healthy People ◽  
Enhanced Depth Imaging ◽  
Control Group ◽  
Depth Imaging ◽  
Subfoveal Choroidal Thickness ◽  
Imaging Optical Coherence Tomography ◽  
Spectralis Oct

66 healthy people (124 eyes) with different degrees of myopia and emmetropia were examined using enhanced depth imaging optical coherence tomography (EDI-OCT) using the “Spectralis OCT”. It was found that the choroid in subjects with medium and high degrees of myopia was significantly thinner than that in the control group. In the study, a negative correlation was found between the subfoveal choroidal thickness and the degree of myopia (r = -0.75, p < 0.0001). It was also found that the subfoveal choroidal thickness decreased for each diopter of myopia by approximately 18.03 μm.

Evaluation of Possible Changes in Intraocular Pressure and Optical Coherence Tomography Measurements in Severe OSAS Patients After 3 Month Positive Airway Pressure Treatment

2021 ◽  
Author(s):  
Nursel Dikmen ◽  
Ayse Idil Cakmak ◽  
Selma Urfalıoğlu
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Corneal Thickness ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Before And After ◽  
Sleep Parameters ◽  
Pre Treatment

Abstract Purpose: To identify and compare possible changes in intraocular pressure (IOP), macular and peripapillary retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) before and after 3 months of positive airway pressure (PAP) in patients with severe OSAS.Materials and Methods: Twenty-five patients diagnosed with severe OSAS in the neurology sleep outpatient clinic were included in the study. Ophthalmologic examinations were performed at the time of diagnosis and after 3 months of PAP treatment. Statistical analysis of comparisons of IOP and OCT measurements taken before and after PAP treatment was performed. Before treatment, the correlations between central corneal thickness (CCT), body mass index (BMI), OCT, IOP and sleep parameters were statistically investigated.Results: When comparisons were made for both eyes, after 3 months of PAP treatment, a statistically significant decrease in IOP, thickening of the macula, and thinning of RNFL in the superior nasal sector were found when compared with the measurements previously taken at the time of diagnosis (p <0.05). There was no correlation between pre-treatment IOP, OCT, CCT, BMI and sleep parameters.Discussion: The inflammatory effects of OSAS on the IOP and macula have been shown to be reversible with a 3-month PAP treatment, but the reversibility of the neurodegenerative effects of OSAS on RNFL with this treatment seems controversial. OCT is a promising technique for monitoring disease progression in patients with severe OSAS under PAP treatment.

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