Malondialdehyde (MDA) as a Marker of Platelet Function in Rats with CCl4-Induced Toxic Hepatopathy

Blood platelets are pivotal cells in the process of hemostasis and thrombosis. In the majority of patients with severe liver disease, platelet function appeared defective. We determinate platelet adhesiveness, aggregability and MDA level, in rats with acute and chronic hepatopathy induced by CCl4 administration. Our data relieves that platelet functions are not only affected in chronic toxic affectation, but also in acute intoxication (p[0.05). Icosanoids production (expressed in MDA levels) are significantly decreased only in chronic CCl4 intoxication (p[0.001). Significant correlation appears between aggregability and MDA (r = -0.78) and adhesiveness and MDA (r = -0.57) in group C, with chronic CCl4 intoxication. The complexity of these platelet functions related to the hepatic disease is still a matter of debate and needs further investigation.

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Severe liver disease is caused by HBV rather than HCV in children with hematological malignancies

The Hematology Journal ◽

10.1038/sj.thj.6200300 ◽

2003 ◽

Vol 4 (5) ◽

pp. 321-327 ◽

Cited By ~ 16

Author(s):

Manal H El-Sayed ◽

Magdy M Mohamed ◽

Amr Karim ◽

Anna-Maria Maina ◽

Filippo Oliveri ◽

...

Keyword(s):

Liver Disease ◽

Hematological Malignancies ◽

Severe Liver ◽

Severe Liver Disease

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HÆMORRHAGE IN SEVERE LIVER DISEASE

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1944.tb31157.x ◽

1944 ◽

Vol 2 (4) ◽

pp. 93-93

Keyword(s):

Liver Disease ◽

Severe Liver ◽

Severe Liver Disease

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Extra Lactate Dehydrogenase Isoenzyme Band in Serum of Patients with Severe Liver Disease

Clinical Chemistry ◽

10.1093/clinchem/17.9.882 ◽

1971 ◽

Vol 17 (9) ◽

pp. 882-885 ◽

Cited By ~ 6

Author(s):

T Lubrano ◽

A A Dietz ◽

H M Rubinstein

Keyword(s):

Liver Disease ◽

Lactate Dehydrogenase ◽

Serum Bilirubin ◽

High Serum ◽

Severe Liver ◽

Additional Band ◽

Dehydrogenase Isoenzyme ◽

Severe Liver Disease ◽

Isoenzyme Patterns ◽

High Serum Bilirubin

Abstract In a study of lactate dehydrogenase isoenzyme patterns in the sera of patients with severe liver disease, who were primarily selected because of an abnormally high serum bilirubin, 42 of 76 patients had an additional band (LDH-T) between isoenzymes 4 and 5 on acrylamide gel. Thirty of the 42 patients died during followup, 24 within a month of recognition of the extra band.

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Disturbance Of Platelet Function In The Nephrotic Syndrome

10.1055/s-0038-1653301 ◽

1981 ◽

Author(s):

E Walter ◽

D Deppermann ◽

K Andrassy ◽

E Weber

Keyword(s):

Nephrotic Syndrome ◽

Platelet Count ◽

Platelet Aggregation ◽

Kidney Function ◽

Platelet Function ◽

Platelet Adhesiveness ◽

Spontaneous Aggregation ◽

Spontaneous Platelet Aggregation ◽

Platelet Functions

Thromboembolic phenomena often (30 %) complicate the nephrotic syndrome. It was therefor investigated, wether disturbed platelet functions play a role in this disease.28 normals, 34 patients with nephrotic syndrome and 18 of them with impaired kidney function were tested. In 20 patients the measurements were repeated after administration of aspirin plus dipyridamo1e.Patients with nephrotic syndrome showed in comparison to normals the following changes: 1. increased platelet count (p < 0.01), 2. enhanced platelet adhesiveness (Wright-test: p < 0.001), 3. increased spontaneous aggregation (PAT I: p < 0.001; PAT III: p < 0.01), 4. enhanced PF 4-activity (heparin neutralisation: p < 0.001), 5. elevated β TG-levels only in impaired kidney function. There was no difference in the reaction of platelets against ADP as well as collagen. The changes in platelet function correlated with the severity of the nephrotic syndrome (proteinurea, hypalbuminaemia, hyperlipo- proteinaemia). After aspirin plus dipyridamole administration spontaneous platelet aggregation and adhesiveness were normalized.There is a disturbance of platelet function in patients with nephrotic syndrome, which can be reversed with antiaggregating agents.

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