Immunosuppressive Effect of the Intraperitonially Injected Pine Needle Distillate in Mice

2003 ◽  
Vol 8 (1) ◽  
pp. 7-12 ◽  
Author(s):  
Young-Jin Chung ◽  
Myung-Won Bae ◽  
Kyeong-Soo Chung
2006 ◽  
Vol 11 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Hye-Sook Choi ◽  
Do Hang ◽  
Seong-Jun Cho ◽  
Se-Chan Kang ◽  
Eun-Soo Sohn ◽  
...  

1992 ◽  
Vol 103 (6) ◽  
pp. 1127-1135 ◽  
Author(s):  
Takashi Hirai ◽  
Hiromi Wada ◽  
Seiki Hasegawa ◽  
Kenji Inui ◽  
Hiroyasu Yokomise ◽  
...  

Author(s):  
Mohamed F. A. Elazab ◽  
Abdelgayed M. Younes ◽  
Alkhateib Y. Gaafar ◽  
Alaa Z. Abu-Bryka ◽  
Mohamed M. Abdel-Daim

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 598
Author(s):  
Ping-Chung Kuo ◽  
Yue-Chiun Li ◽  
Anjar M. Kusuma ◽  
Jason T. C. Tzen ◽  
Tsong-Long Hwang ◽  
...  

Pinus needle tea are very popular in Eastern countries such as Japan, Russia, Korea, and China. Pine needle tea is claimed to have significant anti-aging effects, but no clear evidence has supported this until now. In the present study, five undescribed compounds (1–5) as well as seventy-two known compounds were purified and characterized from the bioactive fraction of methanol extracts of P. taiwanensis needles. Most of the isolates were examined for their anti-inflammatory bioactivity by cellular neutrophil model and six compounds (45, 47, 48, 49, 50, and 51) exhibited a significant inhibition on superoxide anion generation and elastase release with IC50 values ranging from 3.3 ± 0.9 to 8.3 ± 0.8 μM. These anti-inflammatory ingredients were subjected to docking computing to evaluate their binding affinity on the ghrelin receptor, which played an important role in regulating metabolism, with anti-aging effects. Compounds 49, 50, and 51 formed a stable complex with the ghrelin receptor via hydrogen bonds and different types of interactions. These results suggest the flavonoids are responsible for the potential anti-aging effects of pine needle tea.


2014 ◽  
Vol 30 (3) ◽  
pp. 521-526 ◽  
Author(s):  
Leilei Lü ◽  
Zhimin Chen ◽  
Guiheng Xu ◽  
Jianan Zhang ◽  
Qun Xu

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