Adding Germinated Brown Rice Soaked in a Mycelial Culture Broth of Phellinus linteus to Muffins: An Assessment Using the Response Surface Methodology

2011 ◽  
Vol 40 (6) ◽  
pp. 892-902 ◽  
Author(s):  
Kyong-Im Jung ◽  
Eun-Kyung Cho
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Brown Rice ◽  
Culture Broth ◽  
Phellinus Linteus ◽  
Germinated Brown Rice ◽  
Mycelial Culture

scholarly journals Identification of an anticancer compound against HT-29 cells from Phellinus linteus grown on germinated brown rice

2013 ◽  
Vol 3 (10) ◽  
pp. 785-789 ◽  
Author(s):  
Tae-Il Jeon ◽  
Chang-Hwa Jung ◽  
Jeong-Yong Cho ◽  
Dong Ki Park ◽  
Jae-Hak Moon
Keyword(s):  
Brown Rice ◽  
Phellinus Linteus ◽  
Germinated Brown Rice ◽  
Ht 29 ◽  
Anticancer Compound

scholarly journals Phellinus linteus Grown on Germinated Brown Rice Inhibits IgE-Mediated Allergic Activity through the Suppression of FcεRI-Dependent Signaling Pathway In Vitro and In Vivo

2019 ◽  
Vol 2019 ◽  
pp. 1-15
Author(s):  
Ha-Kyoung Kwon ◽  
Hye-Jin Park
Keyword(s):  
Immunoglobulin E ◽  
Calcium Influx ◽  
Brown Rice ◽  
Blue Dye ◽  
Type I ◽  
Dependent Manner ◽  
Phellinus Linteus ◽  
Germinated Brown Rice

Phellinus linteus (PL) has been used as a traditional herbal medicine owing to its immune regulatory activity. Previous studies reported that PL grown on germinated brown rice (PBR) exerted immunomodulatory, anticancer, and anti-inflammatory activities. However, role of PBR on type I hypersensitive reactions has not been studied yet. We found that PBR contained more polyphenolic compounds than PL extract. Among fractions, PBR butanol fraction (PBR-BuOH) significantly contained the most amounts of total polyphenolic contents compared with all extracts or fractions. In this study, anti-allergic activity of PBR-BuOH was examined using in vitro and in vivo models of immunoglobulin E/antigen- (IgE/Ag-) stimulated allergy. The inhibitory activity of degranulation was higher in PBR-BuOH (IC50 41.31 ± 0.14 μg/mL) than in PL-BuOH (IC50 108.07 ± 8.98 μg/mL). We observed that PBR-BuOH suppressed calcium influx and the level of TNF-α and IL-4 mRNA expression in a dose-dependent manner. The phosphorylation of Fyn, Gab2, PI3K, Syk, and IκB protein is reduced by PBR-BuOH. Oral administration of PBR-BuOH inhibited allergic reactions including the extravasation of Evans blue dye, ear swelling, and infiltration of immune cells in mice with passive cutaneous anaphylaxis (PCA). These findings suggest that PBR-BuOH might be used as a functional food, a health supplement, or a drug for preventing type I hypersensitive allergic disease.

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