Comparison of Biological Activities of Ethanol Extracts of Unripe Fruit of Bitter Melon (Momordica charantia L.) Cultivated in Hamyang, Korea

2015 ◽  
Vol 44 (11) ◽  
pp. 1637-1644 ◽  
Author(s):  
Jeong-Han Moon ◽  
Dong-Won Choi ◽  
Seong-Eun Kim ◽  
Ji-Hoon Seomoon ◽  
Su-Young Hong ◽  
...  
Keyword(s):  
Biological Activities ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
Unripe Fruit ◽  
Ethanol Extracts

Effect of the Enhanced Biological Activities and Reduced Bitter Taste of Bitter Melon(Momordica charantia L.) by Roasting

2015 ◽  
Vol 49 (2) ◽  
pp. 107-119 ◽  
Author(s):  
Min Ju Ahn ◽  
◽  
Heung Joo Yuk ◽  
Hee Yul Lee ◽  
Chung Eun Hwang ◽  
...  
Keyword(s):  
Bitter Taste ◽  
Biological Activities ◽  
Momordica Charantia ◽  
Bitter Melon

scholarly journals Investigation of Biological Activities of Wild Bitter Melon (Momordica charantia Linn. Var. Abbreviata Ser.)

Biomolecules ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 211 ◽  
Author(s):  
Thi My Hanh Pham ◽  
Dai-Hung Ngo ◽  
Dai-Nghiep Ngo ◽  
Thanh Sang Vo
Keyword(s):  
Biological Activities ◽  
Ethanol Extract ◽  
Pharmaceutical Products ◽  
Momordica Charantia ◽  
Raw 264.7 Cells ◽  
Dependent Manner ◽  
Bitter Melon ◽  
Concentration Dependent Manner ◽  
Ic50 Value

Wild bitter melon (Momordica charantia L. var. Abbreviata Ser.) is a wild edible variety of M. charantia, often used in folk medicine. In this study, the biological activities of its extract and fractions were investigated in vitro. It was found that ethyl acetate (EA) fraction exhibited high 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity with a half maximal inhibitory concentration (IC50) value of 0.43 ± 0.04 mg/mL, while the chloroform (CF), EA, and n-butanol (Bu) fractions had strong 2,2-azinobis-3-ethyl benzothiazoline-6-sulfonic acid (ABTS)+ scavenging ability with IC50 values of 0.36 ± 0.04 mg/mL, 0.35 ± 0.02 mg/mL, and 0.35 ± 0.05 mg/mL, respectively. Moreover, the EA and Bu fractions exhibited the highest protective effect against H2O2-induced DNA damage in a concentration-dependent manner. Furthermore, the EA fraction was effective in the inhibition of enzyme α-amylase activity with an IC50 value of 0.27 ± 0.029 mg/mL. Finally, it was observed that the production of nitric oxide (NO), a pro-inflammatory mediator, was significantly reduced from LPS-stimulated murine macrophage RAW 264.7 cells by the ethanol extract (ET) and the EA fraction. Therefore, wild bitter melon could be considered as a promising biomaterial for the development of pharmaceutical products.

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