RECOMBINANT TUMOR NECROSIS FACTOR-THYMOSIN-A1: THE IMPACT ON THE EFFECTIVENESS OF NEOADJUVANT CHEMOTHERAPY AND ANGIOGENESIS IN BREAST CANCER

2017 ◽  
Vol 63 (1) ◽  
pp. 76-81
Author(s):  
Lyubov Vladimirova ◽  
Yevgeniya Nepomnyashchaya ◽  
Natalya Podzorova ◽  
Inna Novikova ◽  
Yelena Ulyanova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Neoadjuvant Treatment ◽  
Morphological Examination ◽  
Necrosis Factor Alpha ◽  
Primary Tumors ◽  
The Impact ◽  
Recombinant Tumor Necrosis Factor ◽  
Necrosis Factor

The article covers the results of clinical application of a domestic drug based on recombinant tumor necrosis factor-alpha-thymosin-alpha1 (TNF-T) combined with chemotherapy FAC and РА during neoadjuvant treatment of patients with breast cancer IIB-IIIB stage. In contrast to the standard subcutaneous application method, the authors proposed peritumoral administration of TNF-T to maximize the drug's action directly on the tumor, peritumoral tissue. TNF-T 200000 IU peritumorally on days 1-5 of each treatment course showed significant increase in objective effect rate, including increase in frequency of complete regressions, and decrease in frequency and intensity of chemotherapy complications. Morphological examination revealed an increase rate of medical pathomorphosis grade III-IV, decreased number of microvessels in tumor in comparison with primary tumors

Role of nitric oxide in recombinant tumor necrosis factor-alpha-induced circulatory shock

1996 ◽  
Vol 24 (11) ◽  
pp. 1806-1810 ◽  
Author(s):  
Jan H. Zwaveling ◽  
Jan K. Maring ◽  
Han Moshage ◽  
Robert J. van Ginkel ◽  
Harald J. Hoekstra ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Circulatory Shock ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Recombinant Tumor Necrosis Factor ◽  
Necrosis Factor

scholarly journals Recombinant tumor necrosis factor alpha and interleukin 1 alpha increase expression of c-abl protooncogene mRNA in cultured human marrow stromal cells

1989 ◽  
Vol 86 (17) ◽  
pp. 6788-6792 ◽  
Author(s):  
D F Andrews ◽  
J J Nemunaitis ◽  
J W Singer
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Stromal Cells ◽  
Tumor Necrosis ◽  
Interleukin 1 ◽  
Marrow Stromal Cells ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Recombinant Tumor Necrosis Factor ◽  
Necrosis Factor

Analysis of protooncogene RNA expression in marrow stromal cells from long-term marrow culture demonstrated high levels of c-abl 5-, 6-, and 7-kilobase (kb) RNA transcripts. In experiments on three independently derived simian virus 40-transformed marrow stromal cell lines, the expression of these c-abl transcripts was further increased in response to recombinant tumor necrosis factor alpha (1000 units/ml) and interleukin 1 alpha (10 units/ml). Although lymphocyte-conditioned medium predominantly up-regulated the 5-kb transcript, interleukin 1 alpha primarily affected the 6-kb transcript. The up-regulation of the 5-kb c-abl message correlated with up-regulation of the granulocyte/macrophage colony-stimulating factor transcript and down-regulation of procollagen I transcripts in transformed cells. These data suggest that c-abl plays roles in the regulation of extracellular matrix expression and in the regulation of hematopoietic growth factors by stromal cells.

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