scholarly journals Clinical report of a patient with primary mediastinal B-large cell lymphoma

2021 ◽  
Vol 67 (5) ◽  
pp. 718-723
Author(s):  
Inna Kamaeva ◽  
Irina Lysenko ◽  
Nadezhda Nikolaeva ◽  
Elena Kapuza ◽  
Iurii Lazutin ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Cell Lymphoma ◽  
Vena Cava ◽  
Clinical Manifestations ◽  
B Cell Lymphoma ◽  
Diagnostic Error ◽  
Clinical Report ◽  
Morphological Examination ◽  
Mediastinal Tumors ◽  
Vena Cava Superior

Primary mediastinal B-cell lymphoma is a variant of non-Hodgkin's lymphoma with the predominant involvement of mediastinal lymph nodes, which affects young women. Diagnosis of this nosology is difficult due to the rare involvement of peripheral lymph nodes, as well as the rapid increase of clinical manifestations, such as the syndrome of compression of the vena cava superior and the development of the respiratory failure. The article presents a clinical case of a patient who was operated and complications that occurred due to inadequate diagnostic and therapeutic tactics. There aren`t any descriptions of the clinical manifestations of the disease which could led to a diagnostic error in literature. We present our own observation of a patient with PMBCL and discuss a practical diagnostic algorithms for mediastinal tumors. The diagnosis of PMBCL can be established only as a result of morphological examination, it is important that surgeons and pathologists remember about it. This case is important not only because it provides information about such a lymphoproliferative disease as PMBCL, but also reminds about such a diagnostic error in oncology-treatment without verification. We tried to emphasize the nesessary of strict implementation of the algorithm for differential diagnosis of the anterior mediastinal neoplasms, especially for young people. I hope that this case will contribute to the expansion of knowledge and the prevention of errors in order to achieve better results.

Lymph Node Infarction

2003 ◽  
Vol 127 (1) ◽  
pp. 60-63 ◽  
Author(s):  
James A. Strauchen ◽  
Lorraine K. Miller
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Malignant Lymphoma ◽  
Immunohistochemical Study ◽  
Cell Lymphoma ◽  
Medical Center ◽  
Academic Medical Center ◽  
B Cell Lymphoma ◽  
Antigen Expression ◽  
Formalin Fixed Paraffin Embedded

Abstract Context.—The etiology of lymph node infarction may be difficult or impossible to determine by histologic examination. Lymph node infarction is followed by malignant lymphoma in some but not all patients. The role of immunohistochemistry in the evaluation of lymph node infarction is not well defined. Although it is widely believed that necrotic tissue is not suitable for immunohistochemical study, this view may be inaccurate. Objective.—To determine whether lymphoid antigens are preserved in infarcted lymph nodes and to determine the utility of immunohistochemical staining in the evaluation of lymph node infarction. Design.—Retrospective immunohistochemical study of infarcted lymph nodes using archival formalin-fixed, paraffin-embedded tissue. Setting.—Academic medical center. Patients.—Eleven adult patients with lymph node infarction retrieved from pathology files. Main Outcome Measures.—Results of immunohistochemistry, diagnosis of lymphoma. Results.—Preservation of lymphoid antigens was observed in 4 of 6 cases of lymph node infarction associated with malignant lymphoma, including 3 of 5 cases of diffuse large B-cell lymphoma and 1 case of peripheral T-cell lymphoma. Nonspecific staining was not encountered. In 1 case, in which an infarcted lymph node showed a benign pattern of lymphoid antigen expression, lymphoma has not developed after 5 years. Conclusion.—Lymphoid antigens are frequently preserved in cases of lymph node infarction, and immunohistochemical study of infarcted lymph nodes may provide clinically useful information.

Treatment with doxorubicin-based protocol in cardiac involvement diffuse large B-cell lymphoma: A case report

2021 ◽  
pp. 107815522110351
Author(s):  
Atakan Tekinalp ◽  
Taha U Kars ◽  
Hatice Z Dikici ◽  
Pınar D Yılmaz ◽  
Sinan Demircioğlu ◽  
...  
Keyword(s):  
Heart Failure ◽  
Case Report ◽  
B Cell ◽  
Cardiac Involvement ◽  
Cell Lymphoma ◽  
Vena Cava ◽  
Standardized Uptake Value ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Introduction Cardiac involvement in diffuse large B-cell lymphoma is a rare entity in non-Hodgkin lymphomas. Symptoms are usually related to heart failure. Patients who are severely symptomatic due to cardiac mass could be considered treatment as soon as possible. In this report, we present a patient diagnosed with diffuse large B-cell lymphoma with cardiac involvement. Case Report A 61-year-old female patient was admitted to our unit with gastric biopsy diffuse large B-cell lymphoma. Computerized tomography of the chest and positron emission tomography/computed tomography demonstrated a neoplastic mass in the intra-atrial septum extended to inferior vena cava (5 × 4 cm in size and standardized uptake value maximum 24.6). She was in stage III and in the high-risk group. Because of pronounced heart failure findings associated with the mass-specific chemotherapy was planned early. Management & Outcome Although a fraction of ejection was 60% by echocardiography before the treatment, she had a cardiac risk for doxorubicin due to being over 60 years old and hypertension. Complete remission was achieved after three cycles of rituximab–cyclophosphamide–doxorubicin–vincristine and methylprednisolone protocol including doxorubicin. Treatment was completed with six cycles and she was followed up for three months. Discussion Because of the cardiotoxicity of doxorubicin-based protocols, patients should be evaluated according to cardiac functions before and during the chemotherapy.

scholarly journals Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma

2017 ◽  
Vol 114 (36) ◽  
pp. E7441-E7449 ◽  
Author(s):  
Jun Tang ◽  
Darin Salloum ◽  
Brandon Carney ◽  
Christian Brand ◽  
Susanne Kossatz ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
B Cell ◽  
Pet Imaging ◽  
Fdg Pet ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Imaging Approach ◽  
Imaging Strategy ◽  
Large B Cell

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. DLBCL exhibits highly aggressive and systemic progression into multiple tissues in patients, particularly in lymph nodes. Whole-body 18F-fluodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging has an essential role in diagnosing DLBCL in the clinic; however, [18F]FDG-PET often faces difficulty in differentiating malignant tissues from certain nonmalignant tissues with high glucose uptake. We have developed a PET imaging strategy for DLBCL that targets poly[ADP ribose] polymerase 1 (PARP1), the expression of which has been found to be much higher in DLBCL than in healthy tissues. In a syngeneic DLBCL mouse model, this PARP1-targeted PET imaging approach allowed us to discriminate between malignant and inflamed lymph nodes, whereas [18F]FDG-PET failed to do so. Our PARP1-targeted PET imaging approach may be an attractive addition to the current PET imaging strategy to differentiate inflammation from malignancy in DLBCL.

P0350 BLASTIC NK CELL LYMPHOMA/LEUKEMIA PRESENTING WITH VENA CAVA SUPERIOR SYNDROME: CASE REPORT

2009 ◽  
Vol 20 ◽  
pp. S120
Author(s):  
Ayse Nur Tufan ◽  
Omer Kaya ◽  
Hande Bektas ◽  
Fatih Tufan ◽  
Selim Yavuz ◽  
...  
Keyword(s):  
Case Report ◽  
Nk Cell ◽  
Cell Lymphoma ◽  
Vena Cava ◽  
Vena Cava Superior ◽  
Vena Cava Superior Syndrome

Hemophagocytic Syndrome in a Case of Splenic Large B-Cell Lymphoma

1996 ◽  
Vol 82 (6) ◽  
pp. 621-624 ◽  
Author(s):  
Gualtiero Büchi ◽  
Giuseppe Termine ◽  
Renzo Orlassino ◽  
Mauro Pagliarino ◽  
Roberto Boero ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Lymph Nodes ◽  
B Cell ◽  
Diagnostic Criteria ◽  
Hemophagocytic Syndrome ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Peripheral Lymph ◽  
Large B Cell

A case of splenic large B-cell lymphoma with hemophagocytic syndrome is reported. The difficulties of diagnosis are emphasized especially when peripheral lymph nodes or bone marrow lymphomatous infiltration are not present. Diagnostic criteria for hemophagocytic syndrome and their relationship with the pathogenesis of the disease are also stressed.

scholarly journals Primary cardiac diffuse large B cell lymphoma presenting with superior vena cava syndrome

2009 ◽  
Vol 25 (6) ◽  
pp. e210-e212 ◽  
Author(s):  
Amer Johri ◽  
Tara Baetz ◽  
Phillip A. Isotalo ◽  
Robert L. Nolan ◽  
Anthony J. Sanfilippo ◽  
...  
Keyword(s):  
B Cell ◽  
Superior Vena Cava ◽  
Superior Vena Cava Syndrome ◽  
Cell Lymphoma ◽  
Superior Vena ◽  
Vena Cava ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Vena Cava Syndrome ◽  
Large B Cell

scholarly journals Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation

Blood ◽  
1987 ◽  
Vol 69 (4) ◽  
pp. 1087-1095 ◽  
Author(s):  
P Moller ◽  
G Moldenhauer ◽  
F Momburg ◽  
B Lammler ◽  
M Eberlein-Gonska ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
B Cell ◽  
Clear Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
B Cell Differentiation ◽  
Mediastinal Tumors ◽  
Hla Dr ◽  
Mediastinal Lymphoma ◽  
Predominantly Female

Abstract This article reports eight primary mediastinal tumors occurring in young adults (19 to 43 years, mean 29.4 years), predominantly female (six of eight) adults. Most patients responded badly to aggressive therapy. Progression is presently noted in one patient; five patients died 10, 11, 13, 18, and 22 months after diagnosis. No patient developed leukemia. The tumors were highly proliferative, had a diffuse growth pattern, and comprised clear cells of variable size. They could not be classified histologically, but could, however, be immunohistologically characterized as B cell lymphomas. In all cases, the immunophenotype was LC+, cALLa-, CD19+, CD20+, CD21-, Ig (surface/cytoplasm)-, and PC-1+. In addition, the neoplastic cells exhibited variable defects in the expression of HLA-A,B,C and HLA-DR and inconstant expression of other B cell-restricted/associated antigens. This combination of immunophenotypical and clinical features suggests that the mediastinal clear cell lymphoma (MCCL) is a previously undescribed type of B cell lymphoma corresponding to the terminal steps of B cell differentiation.

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