scholarly journals Effect of electroacupunture on gastric mucosal intestinal trefoil factor gene expression of stress-induced gastric mucosal injury in rats

2006 ◽  
Vol 12 (12) ◽  
pp. 1962 ◽  
Author(s):  
Xi-Ping Li
Keyword(s):  
Gene Expression ◽  
Mucosal Injury ◽  
Gastric Mucosal Injury ◽  
Trefoil Factor ◽  
Intestinal Trefoil Factor ◽  
Factor Gene

scholarly journals Intestinal Trefoil Factor Gene Expression in Intestinal Epithelial Cells Is Not Regulated by Glucocorticoids

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 208A-208A
Author(s):  
Jing Lin ◽  
Ian R Holzman ◽  
Hikaru Kozuma ◽  
Taral Patel ◽  
Ping Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Trefoil Factor ◽  
Intestinal Trefoil Factor ◽  
Factor Gene

scholarly journals Recombinant Adenovirus-Mediated Intestinal Trefoil Factor Gene Therapy for Burn-Induced Intestinal Mucosal Injury

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62429 ◽  
Author(s):  
Yong Sun ◽  
Yun Zhu ◽  
Liangxi Wang ◽  
Xuefei Mao ◽  
Xi Peng ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Recombinant Adenovirus ◽  
Mucosal Injury ◽  
Trefoil Factor ◽  
Intestinal Trefoil Factor ◽  
Factor Gene ◽  
Intestinal Mucosal Injury

Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells

1998 ◽  
Vol 275 (1) ◽  
pp. G85-G94 ◽  
Author(s):  
Chau P. Tran ◽  
Mary Familari ◽  
Lorraine M. Parker ◽  
Robert H. Whitehead ◽  
Andrew S. Giraud
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Trefoil Factor ◽  
Colon Cancer Cells ◽  
Intestinal Trefoil Factor ◽  
Response Element

Intestinal trefoil factor (ITF) gene expression was detected in five colon cancer cell lines. ITF was synthesized by mucous cells of LIM 1215 and LIM 1863 lines, from which it is secreted constitutively. The ITF mRNA transcript was estimated to be 0.6 kb. In LIM 1215 cells, the expression of ITF was potently and dose-dependently inhibited by short-chain fatty acids (butyrate > propionate > acetate) within 8 h of application. The inhibitory effect of butyrate was ablated by actinomycin D and preceded its effects on differentiation of LIM 1215 cells as indicated by induction of alkaline phosphatase activity and counting of periodic acid-Schiff-positive cells. The human ITF promoter contained an 11-residue consensus sequence with high homology to the butyrate response element of the cyclin D1 gene. Mobility shift assays show specific binding of this response element to nuclear protein extracts of LIM 1215 cells. We conclude that butyrate inhibits ITF expression in colon cancer cells and that this effect may be mediated transcriptionally and independently of its effects on differentiation.

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