scholarly journals Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis

2017 ◽  
Vol 23 (18) ◽  
pp. 3322 ◽  
Author(s):  
Basavaraj Kerur ◽  
Heather J Litman ◽  
Julia Bender Stern ◽  
Sarah Weber ◽  
Jenifer R Lightdale ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Young Adults ◽  
Disease Severity ◽  
Activity Index ◽  
Index Score ◽  
Children And Young Adults ◽  
Activity Index Score

Psychosocial Functioning in Children and Young Adults With Juvenile Arthritis

PEDIATRICS ◽  
1988 ◽  
Vol 81 (2) ◽  
pp. 195-202
Author(s):  
Judy A. Ungerer ◽  
Barbara Horgan ◽  
Jeffrey Chaitow ◽  
G. David Champion
Keyword(s):  
High School ◽  
Young Adults ◽  
Primary School ◽  
Disease Severity ◽  
Social Relationships ◽  
Psychosocial Functioning ◽  
Juvenile Arthritis ◽  
Developmental Model ◽  
Physical Strain ◽  
Children And Young Adults

A questionnaire survey of 363 children and young adults with juvenile arthritis was conducted to assess the relations among disease severity, psychosocial functioning, and adjustment in three age groups—primary school, high school, and young adult. Parents were surveyed separately to determine which characteristics of the ill child at different ages most significantly impact the well-being of the family. Indices of psychologic functioning and disease severity were associated with adjustment in the primary school and high school groups, whereas measures of social relationships were strongly associated with adjustment only in the high school group. Relations among measures of psychologic functioning, social relationships, disease severity, and adjustment in young adults were minimal. Level of disease severity was associated with the presence of financial concerns, emotional problems, and physical strain in parents of high school children and young adults. The results emphasize the importance of using a developmental model for understanding the adjustment of individuals with chronic juvenile arthritis and their families.

Changes in Pulmonary Mechanics with Increasing Disease Severity in Children and Young Adults with Cystic Fibrosis

2002 ◽  
Vol 166 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Nicholas Hart ◽  
Michael I. Polkey ◽  
Annick Clément ◽  
Michèle Boulé ◽  
John Moxham ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Young Adults ◽  
Disease Severity ◽  
Pulmonary Mechanics ◽  
Children And Young Adults

scholarly journals Sleep disturbance as a moderator of the association between physical activity and later pain onset among American adults aged 50 and over: evidence from the Health and Retirement Study

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e036219
Author(s):  
Daniel Whibley ◽  
Heidi M Guyer ◽  
Leslie M Swanson ◽  
Tiffany J Braley ◽  
Anna L Kratz ◽  
...  
Keyword(s):  
Physical Activity ◽  
Sleep Disturbance ◽  
Activity Index ◽  
Vigorous Physical Activity ◽  
Index Score ◽  
Health And Retirement Study ◽  
Physical Activity Index ◽  
Activity Index Score ◽  
Incident Pain ◽  
Retirement Study

ObjectiveTo examine whether sleep disturbance modifies the association between physical activity and incident pain.DesignProspective population-based study.SettingHealth and Retirement Study.ParticipantsAmerican adults aged ≥50 years who reported no troublesome pain in 2014 were re-assessed for pain in 2016. Of 9828 eligible baseline respondents, 8036 (82%) had complete follow-up data for adjusted analyses (weighted analysis population N=42 407 222).ExposuresPhysical activity was assessed via interview with questions about time spent in moderate and vigorous physical activity. Sleep disturbance, assessed using a modified form of the Jenkins Sleep Scale, was examined as a potential moderator.Main outcome measureTroublesome pain.ResultsIn weighted analyses, 37.9% of the 2014 baseline pain-free sample participated in moderate or vigorous physical activity once a week or less, with an overall mean Physical Activity Index Score of 9.0 (SE=0.12). 18.6% went on to report troublesome pain in 2016. Each one-point higher on the Physical Activity Index Score was associated with a reduced odds ratio (OR) of incident pain for those who endorsed sleep disturbance never/rarely (OR=0.97, 95% CI 0.94 to 0.99), but not for those who endorsed sleep disturbance sometimes (OR=0.99, 95% CI 0.97 to 1.01) or most of the time (OR=1.01, 95% CI 0.99 to 1.03). The analysis of possible interaction demonstrated that frequency of sleep disturbance moderated the physical activity and incident pain association (Wald test: p=0.02).ConclusionsThe beneficial association of physical activity on reduced likelihood of later pain was only observed in persons who endorsed low levels of sleep disturbance.

Use of Methotrexate in Children and Young Adults Affected by Ulcerative Colitis: A Retrospective Study

2011 ◽  
Vol 106 ◽  
pp. S459
Author(s):  
Alessia Ghiselli ◽  
Cristina Calzolari ◽  
Patrizia Perazzo ◽  
Paola Soriani ◽  
Carmen Madia ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Young Adults ◽  
Retrospective Study ◽  
Children And Young Adults

Association of IL-12B Genetic Polymorphism with the Susceptibility and Disease Severity of Ankylosing Spondylitis

2011 ◽  
Vol 39 (1) ◽  
pp. 135-140 ◽  
Author(s):  
RUEY-HONG WONG ◽  
JAMES CHENG-CHUNG WEI ◽  
CHUN-HUANG HUANG ◽  
HONG-SHEN LEE ◽  
SHANG-YAN CHIOU ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Disease Severity ◽  
Activity Index ◽  
Disease Activity Index ◽  
T Helper 17 ◽  
Tyrosine Kinase 2 ◽  
Polymerase Chain ◽  
Activity Index Score ◽  
Interleukin 23

Objective.Interleukin 23 (IL-23) stimulates the differentiation of T helper 17 (Th17) cells, which are involved in the pathogenesis of ankylosing spondylitis (AS). Binding of IL-23 to the IL-23 receptor complex activates Janus kinases 2 and tyrosine kinase 2, which phosphorylate IL-23R and subsequently promote the transcription of the IL-17 gene. IL-12B encodes a p40 subunit common to IL-12 and IL-23. We evaluated the effects of IL-12B and IL-23R genotype on the occurrence and clinical features of AS.Methods.A total of 362 patients with AS and 362 healthy controls were enrolled in the study. Genotypes of IL-12B A1188C (rs3212227) and IL-23R C2370A (rs10889677) were identified by polymerase chain reaction/restriction fragment-length polymorphism. Disease activity and functional status were assessed by Bath AS indices.Results.Subjects carrying IL-12B CC [matched relative risk (RRm) 1.93, 95% CI 1.23–3.03] and IL-12B AC (RRm 1.73, 95% CI 1.21–2.46) genotypes had a significantly greater risk of developing AS than subjects with the IL-12B AA genotype. Subjects carrying both IL-12B CC and IL-23R AA genotypes also had a significantly higher risk (RRm 2.98, 95% CI 1.51–5.89) of developing AS compared to those with IL-12B AA and IL-23R CC/CA genotypes, and this interaction between IL-12B and IL-23R was significant. Patients with AS who had IL-12B CC and IL-12B AC genotypes had an obviously increased Bath Ankylosing Spondylitis Disease Activity Index score compared to those who carried the IL-12B AA genotype (4.3 vs 3.7).Conclusion.The IL-12B A1188C genotype was associated with the development and disease severity of AS.

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