Sergančiųjų alerginiu rinitu gyvenimo kokybės ir klinikinių simptomų pokytis taikant intranazalinę fototerapiją

Žinoma, kad fototerapija teigiamai veikia imuninius procesus gleivinėje. Yra duomenų, kad intranazalinė fototerapija (IF), skleidžianti UV-A (25 proc.), UV-B (5 proc.) ir regimąją šviesą (70 proc.), gali būti veiksminga gydant alerginį rinitą (AR) nepriklausomai nuo simptomus sukėlusio alergeno, taip pat gali būti taikoma ieškant alternatyvų medikamentiniam gydymui. Tyrimo tikslas. Įvertinti intranazalinės fototerapijos poveikį klinikiniams alerginio rinito simptomams ir gyvenimo kokybei pacientų, sergančių nuolatiniu AR. Tyrimo metodai. Tyrimas atliktas Lietuvos sveikatosmokslų universiteto ligoninės Kauno klinikų Imunologijos ir alergologijos klinikoje. Jame dalyvavo sergantieji nuolatiniu vidutinio sunkumo arba sunkiu AR (ARIA diagnostiniai kriterijai). Alerginis įsijautrinimas patvirtintas odos dūrio mėginiais ir (arba) specifinio imunoglobulino E (Ig E) antikūnų įkvėpiamiems alergenams nustatymu kraujo serume. IF procedūros kartotos tris kartus per savaitę, dviejų savaičių laikotarpiu didinant dozę. Standartinis AR gydymas tyrimo metu nebuvo tęstas. Prieš ir po IF gydymo gyvenimo kokybė vertinta pagal E. Juniper adaptuotą klausimyną (angl. the Rhinoconjunctivitis Quality of Life Questionnaire, standardized version, RQLQ(s)), įvertintas bendrasis nosies simptomų balas (angl. Total Nasal Symptom Score, TNSS). Kiekvienos procedūros metu, naudojant vizualinę atitikmens skalę (angl. Visual Analogue Scale, VAS), įvertintas AR klinikinių simptomų sunkumas. Tyrimo rezultatai. 73 proc. tiriamųjų IF poveikį įvertino teigiamai. Nustatyta, kad po IF gydymo pagerėjo tiriamųjų gyvenimo kokybė, nes statistiškai reikšmingai sumažėjo Klausimyno (RQLQ(s)) visų poskalių balai. Po gydymo statistiškai reikšmingai sumažėjo visi TNSS skalės balai: nosies užgulimas, rinorėja, čiaudulys, miego sutrikimai, bendrieji simptomai. VAS skalės balai po gydymo taip pat sumažėjo statistiškai reikšmingai. Išvados. Intranazinė fototerapija gali palengvinti AR simptomus ir pagerinti pacientų gyvenimo kokybę.

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Pengaruh pemberian vitamin E terhadap eosinofil mukosa hidung dan kualitas hidup penderita rinitis alergi

Oto Rhino Laryngologica Indonesiana ◽

10.32637/orli.v49i20.316 ◽

2019 ◽

Vol 49 (20) ◽

Author(s):

Nanchy Christy ◽

Rus Suheryanto ◽

Mohammad Dwijo Murdiyo

Keyword(s):

Quality Of Life ◽

Vitamin E ◽

Symptom Score ◽

Analogue Scale ◽

Nasal Symptom ◽

Control Group ◽

Double Blind ◽

Treatment Groups ◽

Total Nasal Symptom Score

Latar belakang: Penyakit rinitis alergi (RA) banyak dijumpai dan memberi dampak negatif terhadap produktivitas, kualitas hidup, gangguan tidur, aktivitas di luar rumah, serta gangguan sekolah pada anak. Vitamin E bekerja sebagai antioksidan pada membran sel dan berikatan dengan radikal bebas dengan cara menghambat peroksidasi Poly Unsaturated Fatty Acid (PUFA). Tujuan: Mengetahui pengaruh vitamin E terhadap jumlah eosinofil mukosa hidung dan perbaikan klinis pada penderita rinitis alergi persisten sedang berat. Metode: Menggunakan Randomized Clinical Trial, double blind, pre and post control group dengan perlakuan pemberian terapi semprot hidung triamcinolone acetonide, cetirizine 10 mg, dan vitamin E 400IU selama 4 minggu. Dilakukan penilaian Visual Analogue Scale (VAS) dan Total Nasal Symptom Score (TNSS), serta pemeriksaan eosinofil mukosa hidung pada awal dan 4 minggu setelah perlakuan. Hasil: Didapatkan perbedaan bermakna antara jumlah eosinofil mukosa hidung sebelum dan sesudah pemberian vitamin E pada kelompok perlakuan (p=<0,001). Penurunan jumlah eosinofil mukosa hidung lebih besar dan bermakna pada kelompok perlakuan dibandingkan dengan kelompok kontrol (p=<0,001). Didapat perbaikan kualitas hidup berdasarkan perbaikan nilai VAS dan TNSS yang bermakna setelah perlakuan pada kelompok kontrol maupun perlakuan (p=<0,001), serta didapatkan perbaikan kualitas hidup berdasarkan nilai VAS dan TNSS pada kedua kelompok dengan selisih nilai perbaikan gejala yang lebih besar pada kelompok perlakuan, namun dari perhitungan statistik tidak didapatkan perbedaan yang bermakna. Kesimpulan: Vitamin E 400IU menurunkan jumlah eosinofil mukosa hidung secara bermakna pada pasien rinitis alergi persisten sedang berat. Perbaikan nilai TNSS pada penggunaan vitamin E 400IU lebih baik dibandingkan subjek yang mendapat plasebo, walaupun tidak berbeda secara bermakna.Kata kunci: rinitis alergi, Vitamin E, Total Nasal Symptom Score ABSTRACT Background: Allergic rhinitis (AR) is an allergic disease frequently found and has a negative impact on productivity, quality of life, sleep disorder, outdoors activities, and school disruption in children. Vitamin E works as an antioxidant in cell membranes through binding free radicals by inhibiting peroxidation of Poly Unsaturated Fatty Acids (PUFA). Purpose: To find out the effect of vitamin E administration on nasal mucosa eosinophil counts and the clinical improvement in patients with moderate severe persistent AR. Methods: A double blind randomized clinical trial, pre and post control group, given therapy of triamcinolone acetonide nasal spray, cetirizine 10 mg, and vitamin E 400 IU orally for 4 weeks. Evaluation by Visual Analogue Scale (VAS) and Total Nasal Symptom Score (TNSS), as well as nasal mucosal eosinophils count at baseline and 4 weeks after treatment. Results: There was a significant difference on the number of nasal mucosal eosinophils before and after vitamin E administration in the treatment group (p = <0.001). A greater and more significant decrease in the number of nasal mucosal eosinophils in the treatment group compared to control group (p = <0.001). Significant improvement of VAS and TNSS after treatment in the control and treatment groups (p = <0.001) and quality of life improvement based on VAS and TNSS values in both control and treatment groups, but the statistical calculations showed no significant differences between the two groups. Conclusion: Vitamin E 400IU significantly reduce the number of nasal mucosal eosinophils in patients with moderate severe persistent AR.

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1291: Impact of Bother or Satisfaction Specific to Each Symptom of International Prostate Symptom Score (IPSS) on Quality of Life (QOL) Evaluated with a Novel Visual Analogue Scale (VAS) Questionnaire

The Journal of Urology ◽

10.1016/s0022-5347(18)35436-3 ◽

2005 ◽

Vol 173 (4S) ◽

pp. 350-350

Author(s):

So Ushijima ◽

Osamu Ukimura ◽

Kei Suzuki ◽

Naoki Hirahara ◽

Tsuyoshi Iwata ◽

...

Keyword(s):

Quality Of Life ◽

Visual Analogue Scale ◽

Symptom Score ◽

Analogue Scale ◽

International Prostate Symptom Score

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Assessment of quality of life measured by rhinoconjuctivits quality of life questionnaire in patients of allergic rhinitis treated with commonly used oral antihistaminics

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20193186 ◽

2019 ◽

Vol 8 (8) ◽

pp. 1830

Author(s):

Ganesh S. Pentewar ◽

Ranjit J. Wagh

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Symptom Score ◽

Life Questionnaire ◽

Open Label ◽

Treatment Groups ◽

Quality Of Life Questionnaire ◽

Nasal Symptoms ◽

The Impact

Background: Nasal and non-nasal symptoms in allergic rhinitis (AR) can be assessed by measuring health related quality of life (HRQOL). Present study was to assess the impact of use of antihistaminic in AR which will affect the work productivity, sleep, frequent visits to health care professional and expenditure on medicines. For this evaluation, Rhinoconjuctivits Quality Of Life Questionnaire (RQLQ) has been used.Methods: In this study 52 patients with AR were randomized in an open-label, 4-arm, parallel group, single center study. Questionnaire information was obtained about allergy-related RQLQ. Subjects received either Tablet Cetirizine 5 mg, Levocetirizine 5 mg, Loratidine 5 mg or Fexofenadine 120 mg. Changes from baseline until the end of study visit (1 week following) were evaluated by RQLQ.Results: When compared between treatment groups using one-way ANOVA it was observed that there is no variation in RQLQ overall Score in all the four treatment groups and there is no difference from treatment to treatment. Overall RQLQ score was reduced maximum in Levocetirizine group. Individual symptoms of RQLQ that is sleep score, non-hay fever, practical problem, nasal symptom score, Eye symptom Score, activities Score, and emotion score were also improved in the Levocetirizine group.Conclusions: Patients of all four study groups showed an improved perception of their HRQL according to the RQLQ. Significant improvements are reported in nasal symptoms, daily activities, sleep and psychological impact. Our results provide support for an AR and its impact on quality of life. Our recommendation stipulating that levocetirizine is superior to rest drug group for the treatment of AR with safety and tolerability.

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Application of SNOT-22 test and visual analogue scale in quality of life evaluation in patients with allergic rhinitis

Folia Medica ◽

10.3897/folmed.63.e55256 ◽

2021 ◽

Vol 63 (3) ◽

pp. 337-347

Author(s):

Atanas N. Vlaykov

Keyword(s):

Quality Of Life ◽

Allergic Rhinitis ◽

Visual Analogue Scale ◽

Analogue Scale ◽

Nasal Congestion ◽

Life Questionnaire ◽

Control Groups ◽

And Control ◽

Snot 22

Introduction: Chronic nasal congestion in patients with allergic rhinitis can lead to sleep disorders and to sleep apnoea which, in combination with fatigue, can induce systemic effects, including irritability, weakness, malaise, and decreased appetite, growth retardation in adolescents, resulting in severe worsening of quality of life. Also, allergic rhinitis can affect social life, school performance, and productivity, especially in patients with severe disease. Aim: The aim of the present case-control study was to investigate the impact of quality-of-life impairment and the main contributing symptoms in patients with allergic rhinosinusitis.Materials and methods: During the survey from January to December 2018, 139 participants (111 with allergic rhinitis and 28 controls) were enrolled in the study. Participants in the clinical and control groups were invited to complete a quality-of-life questionnaire for patients with sino-nasal pathology (SNOT-22). For results, a comparison in terms of eye affecting itching, burning, redness, and tearing sensation, a 10-grade visual analogue scale table was presented. Results: Comparing the clinical and control groups of healthy patients in the first SNOT-22, the value was significantly elevated as expected. The mean score (SNOT-22 total score) of the twenty-two symptom scores in patients was 2.52±0.93 (0-5); by comparison, the value in the control group was only 0.64±0.11, with the difference being statistically significant (p=0.001). The results of the visual analogue scale for which the patients were asked to note the level of eye impairment: redness, burning, itching, and tearing that contributed to their negative sense of the quality of life, were eloquent. A statistically significant difference was found between participants with intermittent and persistent forms (6.06±0.20 vs. 3.00±0.25, p=0.001), and between the entire clinical group with AR and the healthy controls included in the study (4.48±0.22 versus 0.21±0.03, p=0.000). Conclusions: Summarising the results of our study and the available literature, we have concluded that nasal congestion and the abundance of secretions are symptoms that disrupt mostly the quality of life in AR patients and significantly affect the quality of sleep and are inevitable consequences of both daytime tone and productivity.The rich palette of symptoms that lead to deterioration of the mental and physical well-being of those affected by AR necessitates the need to sharpen the attention of professionals working for this type of pathology in order to strive to detail and differentiate the specific complaint and degree of quality of life deterioration.

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Alexithyme Patientenmerkmale und Lebensqualität – Eine Querschnittsstudie an 79 ambulanten Patienten mit Angststörungen

Zeitschrift für Psychiatrie Psychologie und Psychotherapie ◽

10.1024/1661-4747/a000136 ◽

2013 ◽

Vol 61 (1) ◽

pp. 17-26 ◽

Cited By ~ 2

Author(s):

Katrin Leenen ◽

Michael Rufer ◽

Hanspeter Moergeli ◽

Hans-Jörgen Grabe ◽

Josef Jenewein ◽

...

Keyword(s):

Quality Of Life ◽

World Health ◽

Life Questionnaire ◽

World Health Organization Quality ◽

Fand Sich ◽

Quality Of Life Questionnaire ◽

Organization Quality ◽

Health Organization ◽

Tas 20

Aus Untersuchungen in der Normalbevölkerung ist bekannt, dass Menschen mit erhöhten Alexithymiewerten eine verminderte Lebensqualität (LQ) aufweisen. Für Patienten mit psychischen Störungen wurde dieser Zusammenhang jedoch kaum untersucht. Ziel dieser Studie war es, den möglichen Zusammenhang zwischen alexithymen Patientenmerkmalen und der LQ bei Patienten mit Angststörungen zu überprüfen. Bei 79 ambulanten Patienten mit Angststörungen wurden alexithyme Charakteristika mit der Toronto Alexithymia Scale (TAS-20), die LQ mit der Kurzversion des World Health Organization Quality of Life Questionnaire 100 (WHOQOL-BREF) erfasst. Darüber hinaus fand eine Erhebung der psychischen Symptombelastung (SCL-90-R) und depressiven Symptomatik (MADRS) statt. Mittels hierarchischer Regressionsanalysen wurde der Zusammenhang zwischen der alexithymen Charakteristika und den unterschiedlichen LQ-Domänen berechnet. Die Patienten zeigten eine im Vergleich zur Normalbevölkerung deutlich verminderte LQ. Als Hauptergebnis fand sich, auch nach Kontrolle von Depression, Ängstlichkeit und Geschlecht, ein signifikanter Zusammenhang zwischen den beiden TAS-20 Subskalen Schwierigkeiten, Gefühle zu identifizieren und zu beschreiben und vor allem der psychischen LQ. Unsere Ergebnisse sprechen dafür, bei der Diagnostik und Therapieplanung von Patienten mit Angststörungen alexithyme Merkmale einzubeziehen. Im Falle von ausgeprägten alexithymen Merkmalen sollten psychotherapeutische Interventionen zur Verbesserung der Schwierigkeiten Gefühle wahrzunehmen und zu kommunizieren in Betracht gezogen werden.

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